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  1. No Access

    Article

    Myriocin suppresses tumor growth by modulating macrophage polarization and function through the PI3K/Akt/mTOR pathway

    Macrophages within the tumor microenvironment (TME), referred to as tumor-associated macrophages (TAMs), are involved in various aspects of tumor progression including initiation, angiogenesis, metastasis, imm...

    Hyeonha Jang, Uttam Ojha, Ji-Hak Jeong, Keun-Gyu Park… in Archives of Pharmacal Research (2023)

  2. No Access

    Article

    Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity

    Chaperon-mediated autophagy (CMA) has taken on a new emphasis in cancer biology. However, the roles of CMA in hypoxic tumours are poorly understood. We investigated the anti-tumour effects of the natural produ...

    Jun-Kyu Byun, Sun Hee Lee, Eui Jung Moon, Myo-Hyeon Park… in British Journal of Cancer (2023)

  3. No Access

    Article

    Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin

    Tumor microenvironment consists of various kind of cells, forming complex interactions and signal transductions for tumor growth. Due to this complexity, targeting multiple kinases could yield improved clinica...

    Ji-Hak Jeong, Uttam Ojha, Hyeonha Jang, Soohyun Kang, Sunhee Lee… in Cellular Oncology (2023)

  4. Article

    Open Access

    Tie2-mediated vascular remodeling by ferritin-based protein C nanoparticles confers antitumor and anti-metastatic activities

    Conventional therapeutic approaches for tumor angiogenesis, which are primarily focused on the inhibition of active angiogenesis to starve cancerous cells, target the vascular endothelial growth factor signali...

    Young Sun Choi, Hyeonha Jang, Biki Gupta, Ji-Hak Jeong… in Journal of Hematology & Oncology (2020)

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