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Article
Association between dental diseases and oral hygiene care and the risk of vertebral fracture: a nationwide cohort study
Periodontal disease and increased missing teeth were associated with incident vertebral fractures. In contrast, professional dental cleaning and frequent tooth brushing, was associated with a lower risk of ver...
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Article
Open AccessAssociations of overweight and obesity with cardiometabolic risk factor clusters among Korean adolescents
This study investigated the association between overweight, obesity, and cardiometabolic risk factor clusters in Korean adolescents. We included 2182 participants (1161 boys and 1021 girls) aged 12–18 years fr...
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Article
Relationship of domain-specific quality of life with body mass index and waist circumference in a Korean elderly population
Obesity affects health-related quality of life (QoL); however, their relationship among elderly Asians is not well known.
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Article
Effectiveness of liraglutide 3 mg for the treatment of obesity in a real-world setting without intensive lifestyle intervention
We investigated the efficacy and safety of liraglutide 3 mg daily in combination with diet and exercise 2, 4, and 6 months after initiation in real-world settings in Korea.
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Article
TFEB–GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response
TFEB, a key regulator of lysosomal biogenesis and autophagy, is induced not only by nutritional deficiency but also by organelle stress. Here, we find that Tfeb and its downstream genes are upregulated together w...
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Article
Open AccessBody mass index trajectories and the risk for Alzheimer’s disease among older adults
The effect of body mass index (BMI) changes and variability on the risk for Alzheimer’s disease (AD) remains unclear. We analyzed 45,076 participants, whose BMI were measured on phase 1 (2002–2003), phase 2 (2...
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Article
Female reproductive factors and the risk of Parkinson’s disease: a nationwide cohort study
There are conflicting finds in the literature regarding the association of female estrogen status and the incidence of Parkinson’s disease (PD). We aimed to investigate whether female reproductive factors are ...
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Article
Depot-specific UCP1 expression in human white adipose tissue and its association with obesity-related markers
This study investigated depot-specific mRNA expression of uncoupling protein 1 (UCP1) in human white adipose tissue (WAT) and its association with obesity-related markers.
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Article
Low serum cholesterol as a risk factor for kidney and bladder cancer among Korean men: using a national cohort sample
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Article
Relationship between low handgrip strength and quality of life in Korean men and women
Handgrip strength is strongly related to muscle power in the extremities and is an important index for diagnosing sarcopenia. We evaluated the relationship between handgrip strength and quality of life (QoL) i...
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Article
Open AccessEnhanced ANGPTL2 expression in adipose tissues and its association with insulin resistance in obese women
Angiopoietin-like protein 2 has been proposed to be a key mediator linking obesity and insulin resistance. However, no detailed study of ANGPTL2 expression in human adipose tissues has yet been reported. To in...
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Article
Prevalence and associated risk factors for osteoporosis in Korean men
Osteoporosis has become an important health concern even in men. We aimed to analyze its prevalence and associated factors in Korean men. Low socioeconomic status, unhealthy lifestyle, and chronic kidney disea...
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Article
Metabolic syndrome and incidence of breast cancer in middle-aged Korean women: a nationwide cohort study
To evaluate the risk of breast cancer in middle-aged women with metabolic syndrome using the National Health Insurance Service-National Sample Cohort (NHIS-NSC).
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Article
Open AccessEnhanced biglycan gene expression in the adipose tissues of obese women and its association with obesity-related genes and metabolic parameters
Extracellular matrix (ECM) remodeling dynamically occurs to accommodate adipose tissue expansion during obesity. One non-fibrillar component of ECM, biglycan, is released from the matrix in response to tissue ...
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Article
Longitudinal Changes in Serum Levels of Angiopoietin-Like Protein 6 and Selenoprotein P After Gastric Bypass Surgery
Bariatric surgery has beneficial effects on weight loss and metabolic profiles. Recent evidence suggests that liver-derived hepatokines play a role in the pathophysiology of metabolic diseases. However, few st...
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Article
Serum SPARC and Matrix Metalloproteinase-2 and Metalloproteinase-9 Concentrations after Bariatric Surgery in Obese Adults
Remodeling of the extracellular matrix (ECM) of adipose tissue is regarded as part of the pathophysiology of obesity. Secreted protein acidic and rich in cysteine (SPARC) was the first ECM protein described in...
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Article
Fibronectin Gene Expression in Human Adipose Tissue and Its Associations with Obesity-Related Genes and Metabolic Parameters
Limited data are available on the in vivo expression of fibronectin, one of the main extracellular matrix components. We investigated the expression of fibronectin in abdominal visceral adipose tissue (VAT) an...
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Article
Abdominal obesity is associated with stress urinary incontinence in Korean women
This study investigated the relationship between abdominal obesity and stress urinary incontinence in Korean women. Women aged 30 and over, who visited the Department of Family Medicine of Asan Medical Center ...
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Article
Single nucleotide variants in the β2-adrenergic and β3-adrenergic receptor genes explained 18.3% of adolescent obesity variation
Associations of obesity with its candidate genes, β-adrenergic receptor genes (ADRBs), peroxisome proliferator-activated receptor-γ (PPARγ), and uncoupling proteins (UCPs) were studied in Korean adolescents. We a...
