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Article
Phenotypic and functional alterations of bone marrow MSCs exposed to multiple myeloma cells
The direct and indirect interactions between multiple myeloma (MM) cells and bone marrow mesenchymal stromal cells (MSCs) play crucial roles in the formation of the bone marrow environment, disease progression...
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Article
Establishment of a small-cell lung cancer (SCLC) mouse model using enhanced cancer stem-cell-functioning 3D SCLC spheroids
Despite its low incidence rate, small-cell lung cancer (SCLC), which accounts for approximately 10%–15% of all lung cancers, is concerningly characterized by its rapid progression, strong metastatic potential,...
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Article
Open AccessGene expression signatures associated with sensitivity to azacitidine in myelodysplastic syndromes
Allogeneic stem cell transplantation is currently the only curative treatment option for myelodysplastic syndromes (MDS). Pre-transplant debulking treatment have been employed for advanced MDS and we previousl...
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Article
Open AccessEffects of decitabine on allogeneic immune reactions of donor lymphocyte infusion via activation of dendritic cells
Successful prevention of post-transplantation relapse after donor lymphocyte infusion (DLI) depends on its capability to mediate an effective graft-versus-leukemia (GVL) response while minimizing DLI-related t...
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Article
Forced expression of CD200 improves the differentiation capability and immunoregulatory functions of mesenchymal stromal cells
In order to identify specific mesenchymal stromal cell (MSC) populations with enhanced therapeutic efficacy, we evaluated the functional changes associated with the stable expression of CD200, which is associa...
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Article
Open AccessEpigenetic modification of mesenchymal stromal cells enhances their suppressive effects on the Th17 responses of cells from rheumatoid arthritis patients
The aim of this study was to investigate if epigenetically modified human mesenchymal stromal cells (hMSCs) can regulate the Th17-related immune responses.
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Article
Enhancement of human mesenchymal stem cell differentiation by combination treatment with 5-azacytidine and trichostatin A
To enhance the differentiation of mesenchymal stem cells (MSCs) and their epigenetic status by modification using hypomethylating agents (HMAs) and histone deacetylase inhibitors (HDACs).
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Article
TrkC promotes survival and growth of leukemia cells through Akt-mTOR-Dependent Up-Regulation of PLK-1 and Twist-1
It has been suggested that activation of receptor PTKs is important for leukemogenesis and leukemia cell response to targeted therapy in hematological malignancies including leukemia. PTKs induce activation of...
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Article
Wnt inhibitors enhance chondrogenesis of human mesenchymal stem cells in a long-term pellet culture
The long-term effects (~3 weeks) of two Wnt inhibitors (dickkopf [DKK]-1 and secreted frizzled-related protein [sFRP]-1), on the chondrogenic differentiation of human mesenchymal stem cells (hMSCs) was determi...
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Article
A genetic link between cold responses and flowering time through FVE in Arabidopsis thaliana
Cold induces expression of a number of genes that encode proteins that enhance tolerance to freezing temperatures in plants1,2. A cis-acting element responsive to cold and drought, the C-repeat/dehydration-respon...
