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Article
Open AccesstRF-His-GTG-1 enhances NETs formation and interferon-α production in lupus by extracellular vesicle
Hyperactive neutrophil extracellular traps (NETs) formation plays a crucial role in active severe systemic lupus erythematosus (SLE). However, what triggers the imbalance in dysregulated NETs formation in SLE ...
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Article
Open AccessSARS-CoV-2 primed platelets–derived microRNAs enhance NETs formation by extracellular vesicle transmission and TLR7/8 activation
Hyperactive neutrophil extracellular traps (NETs) formation plays a key role in the pathogenesis of severe COVID-19. Extracellular vesicles (EVs) are vehicles which carry cellular components for intercellular ...
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Article
Open AccessMicroRNA-223 inhibits neutrophil extracellular traps formation through regulating calcium influx and small extracellular vesicles transmission
Modulation of miRNAs and neutrophil extracellular traps (NETs) formation are both implicated in inflammatory disorders. Adult-onset Still’s disease (AOSD) is a systemic autoinflammatory disease with neutrophil...
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Article
Open AccessCUX2, BRAP and ALDH2 are associated with metabolic traits in people with excessive alcohol consumption
Molecular mechanisms that prompt or mitigate excessive alcohol consumption could be partly explained by metabolic shifts. This genome-wide association study aims to identify the susceptibility gene loci for ex...
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Article
Open AccessConstruction of polycistronic baculovirus surface display vectors to express the PCV2 Cap(d41) protein and analysis of its immunogenicity in mice and swine
To increase expression levels of the PCV2 Cap(d41) protein, novel baculovirus surface display vectors with multiple expression cassettes were constructed to create recombinant baculoviruses BacSC-Cap(d41), Bac...
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Article
Open AccessBovine ephemeral fever virus triggers autophagy enhancing virus replication via upregulation of the Src/JNK/AP1 and PI3K/Akt/NF-κB pathways and suppression of the PI3K/Akt/mTOR pathway
Autophagy plays an important role in cellular response to pathogens. However, the impact of the autophagy machinery on bovine ephemeral fever virus (BEFV) infection is not yet determined. A recent study in our...
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Plant-Made Vaccines Against Avian Reovirus
Viral arthritis, chronic respiratory disease, malabsorption syndrome, hepatitis and myocarditis cause considerable economic losses in the poultry industry and are directly or indirectly linked to avian reoviru...
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Article
Open AccessAvian reovirus p17 and σA act cooperatively to downregulate Akt by suppressing mTORC2 and CDK2/cyclin A2 and upregulating proteasome PSMB6
Although we have shown that avian reovirus (ARV) p17-mediated inhibition of Akt leads to induction of autophagy, the precise mechanisms remain largely unknown. This study has identified a specific mechanism by...
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Article
Open AccessMuscovy duck reovirus σNS protein triggers autophagy enhancing virus replication
Muscovy duck reovirus (MDRV) causes high morbidity and mortality in Muscovy ducklings at 10 days old and can persist in an infected flock until the ducklings of 6 weeks old. It shares common physicochemical pr...
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Article
Open AccessRisk Factors and Outcomes of Nontuberculous Mycobacterial Disease among Rheumatoid Arthritis Patients: A Case-Control study in a TB Endemic Area
Increasing evidence indicates that the risk of nontuberculous mycobacteria (NTM) disease is elevated in patients with rheumatoid arthritis (RA). However, the risk factors and outcomes for NTM disease among RA ...
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Article
Open AccessCharacterization of emerging Newcastle disease virus isolates in China
Newcastle disease (ND) is a devastating worldwide disease of poultry characterized by increased respiration, circulatory disturbances, hemorrhagic enteritis, and nervous signs. Sequence analysis shows several ...
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Article
Avian reovirus S1133-induced apoptosis is associated with Bip/GRP79-mediated Bim translocation to the endoplasmic reticulum
In this study the mechanism of avian reovirus (ARV) S1133-induced pathogenesis was investigated, with a focus on the contribution of ER stress to apoptosis. Our results showed that upregulation of the ER stres...
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Article
Application of Neural Networks and Optimization Model in Conjunctive Use of Surface Water and Groundwater
This study develops an optimization model for the large-scale conjunctive use of surface water and groundwater resources. The aim is to maximize public and irrigation water supplies subject to groundwater-leve...
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Article
Development of a loop-mediated isothermal amplification method for rapid detection of pigeon circovirus
There are no effective antiviral treatments for pigeon circovirus (PiCV); thus, rapid diagnosis is critical for effective control of the disease caused by this virus. The recent development of a novel LAMP tec...
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Article
Open AccessPorcine epidemic diarrhea virus E protein causes endoplasmic reticulum stress and up-regulates interleukin-8 expression
Porcine epidemic diarrhea virus (PEDV) is an important pathogen in swine and is responsible for substantial economic losses. Previous studies suggest that the PEDV E protein plays an important role in the vira...
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Article
Avian reovirus S1133-induced DNA damage signaling and subsequent apoptosis in cultured cells and in chickens
In this study, intracellular signaling in ARV S1133-mediated apoptosis was investigated. A microarray was used to examine the gene expression profiles of cells upon ARV S1133 infection and ARV-encoded pro-apop...
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Article
Open AccessAGE-BSA down-regulates endothelial connexin43 gap junctions
Advanced glycation end products generated in the circulation of diabetic patients were reported to affect the function of vascular wall. We examined the effects of advanced glycation end products-bovine serum ...
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Article
Bovine ephemeral fever virus-induced apoptosis requires virus gene expression and activation of Fas and mitochondrial signaling pathway
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Article
Characterization of the activities of p21Cip1/Waf1 promoter-driven reporter systems during camptothecin-induced senescence-like state of BHK-21 cells
It was attempted in this work to establish a cell line in which senescent cells can be readily and directly identified in situ in live culture. Transcriptional activation of p21Cip1/Waf1 gene is known to be one o...
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Article
A novel gene homologous to teashirt is differentially expressed in neonatal mouse skin during development of hair follicles
Neonatal mouse skin is useful for studying changes in gene expression during development of hair follicles, as the mitotic activity of skin cells changes shortly after birth. Using ribonucleic acid (RNA) diffe...
