45 Result(s)

Article

Correction: The long noncoding RNA GAS5 negatively regulates the adipogenic differentiation of MSCs by modulating the miR-18a/CTGF axis as a ceRNA

Ming Li, Zhongyu **e, Peng Wang, **teng Li, Wenjie Liu, Su’an Tang… in Cell Death & Disease (2024)

Article

EFHD1 promotes osteosarcoma proliferation and drug resistance by inhibiting the opening of the mitochondrial membrane permeability transition pore (mPTP) by binding to ANT3

Chemoresistance is the main obstacle in the clinical treatment of osteosarcoma (OS). In this study, we investigated the role of EF-hand domain-containing protein 1 (EFHD1) in OS chemotherapy resistance. We fou...

**n Shen, Mengjun Ma, Rujia Mi, Jiahao Zhuang… in Cellular and Molecular Life Sciences (2024)

Article

Retraction Note: Reduced immunomodulation potential of bone marrow-derived mesenchymal stem cells induced CCR4⁺CCR6⁺ Th/Treg cell subset imbalance in ankylosing spondylitis

Yanfeng Wu, Mingliang Ren, Rui Yang, **njun Liang… in Arthritis Research & Therapy (2024)

Article

Low expression of ZFP36L1 in osteosarcoma promotes lung metastasis by inhibiting the SDC4-TGF-β signaling feedback loop

ZFP36L1, which is a negative regulator of gene transcripts, has been proven to regulate the progression of several carcinomas. However, its role in sarcoma remains unknown. Here, by using data analyses and in ...

Mengjun Ma, Jiahao Zhuang, Hongyu Li, Rujia Mi, Yihui Song, Wen Yang, Yixuan Lu… in Oncogene (2024)

Article

Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis

Increasing evidence indicates that circular RNAs (circRNAs) accumulate in aging tissues and nonproliferating cells due to their high stability. However, whether upregulation of circRNA expression mediates stem...

Fenglei Chen, Shan Wang, Chenying Zeng, Su’an Tang… in Cellular and Molecular Life Sciences (2023)

Article

Correction: Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

**teng Li, Feng Ye, **aojun Xu, Peitao Xu, Peng Wang… in Journal of Nanobiotechnology (2023)

Article

Targeting macrophage M1 polarization suppression through PCAF inhibition alleviates autoimmune arthritis via synergistic NF-κB and H3K9Ac blockade

Sustained inflammatory invasion leads to joint damage and progressive disability in several autoimmune rheumatic diseases. In recent decades, targeting M1 macrophage polarization has been suggested as a promis...

**teng Li, Feng Ye, **aojun Xu, Peitao Xu, Peng Wang… in Journal of Nanobiotechnology (2023)

Article

ALKBH5 facilitates CYP1B1 mRNA degradation via m6A demethylation to alleviate MSC senescence and osteoarthritis progression

Improving health and delaying aging is the focus of medical research. Previous studies have shown that mesenchymal stem cell (MSC) senescence is closely related to organic aging and the development of aging-re...

Guiwen Ye, **teng Li, Wenhui Yu, Zhongyu **e… in Experimental & Molecular Medicine (2023)

Article

Author Correction: Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

Wenhui Yu, Zhongyu **e, **teng Li, Jiajie Lin, Zepeng Su, Yunshu Che… in Bone Research (2023)

Article

Super enhancers targeting ZBTB16 in osteogenesis protect against osteoporosis

As the major cell precursors in osteogenesis, mesenchymal stem cells (MSCs) are indispensable for bone homeostasis and development. However, the primary mechanisms regulating osteogenic differentiation are con...

Wenhui Yu, Zhongyu **e, **teng Li, Jiajie Lin, Zepeng Su, Yunshu Che… in Bone Research (2023)

Article

A novel Anti-ROS osteoblast-specific delivery system for ankylosing spondylitis treatment via suppression of both inflammation and pathological new bone formation

Ankylosing spondylitis (AS) is a common rheumatic disorder distinguished by chronic inflammation and heterotopic ossification at local entheses sites. Currently available medications, including nonsteroidal an...

Guan Zheng, **aoshuai Peng, Yunhui Zhang, Peng Wang… in Journal of Nanobiotechnology (2023)

Article

LncRNA MRF drives the regulatory function on monocyte recruitment and polarization through HNRNPD-MCP1 axis in mesenchymal stem cells

Mesenchymal stem cells (MSCs) exhibit two bidirectional immunomodulatory abilities: proinflammatory and anti-inflammatory regulatory effects. Long noncoding RNAs (lncRNAs) have important functions in the immun...

Jiajie Lin, Zhongyu **e, Zhaoqiang Zhang, Ming Li… in Journal of Biomedical Science (2022)

Article

Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis

An imbalance of human mesenchymal stem cells (hMSCs) adipogenic and osteogenic differentiation is crucial in the pathogenesis of osteoporosis, and elucidation of the underlying mechanism is urgently needed. AP...

Yunhui Zhang, Wenjie Liu, Weiquan Yuan… in Cellular and Molecular Life Sciences (2022)

Article

Correction to: CCR9 initiates epithelial–mesenchymal transition by activating Wnt/β-catenin pathways to promote osteosarcoma metastasis

Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye… in Cancer Cell International (2022)

Article

Single-cell RNA sequencing analysis of human bone-marrow-derived mesenchymal stem cells and functional subpopulation identification

Mesenchymal stem cells (MSCs) are a common kind of multipotent cell in vivo, but their heterogeneity limits their further applications. To identify MSC subpopulations and clarify their relationships, we perfor...

Zhongyu **e, Wenhui Yu, Guiwen Ye, **teng Li… in Experimental & Molecular Medicine (2022)

Article

Osteogenic differentiation of mesenchymal stem cells promotes c-Jun-dependent secretion of interleukin 8 and mediates the migration and differentiation of CD4⁺ T cells

The immune system and the skeletal system have complex interactions in the bone marrow and even in the joints, which has promoted the development of the concept of osteoimmunology. Some evidence has indicated ...

Feng Ye, **teng Li, Peitao Xu, Zhongyu **e, Guan Zheng… in Stem Cell Research & Therapy (2022)

Article

A new and spontaneous animal model for ankylosing spondylitis is found in cynomolgus monkeys

Ankylosing spondylitis is a progressive, disabling joint disease that affects millions worldwide. Given its unclear etiology, studies of ankylosing spondylitis relied heavily on drug-induced or transgenic rode...

Huanhuan Jia, Meili Chen, Yanzhen Cai, **aoling Luo… in Arthritis Research & Therapy (2022)

Article

GTSE1 is possibly involved in the DNA damage repair and cisplatin resistance in osteosarcoma

G2 and S phase-expressed-1 (GTSE1) negatively regulates the tumor-suppressive protein p53 and is potentially correlated with chemoresistance of cancer cells. This study aims to explore the effect of GTSE1 on t...

Chaofan **e, Wei **ang, Huiyong Shen… in Journal of Orthopaedic Surgery and Research (2021)

Article

CCR9 initiates epithelial–mesenchymal transition by activating Wnt/β-catenin pathways to promote osteosarcoma metastasis

Osteosarcoma (OS) patients with lung metastasis have poor prognoses, and effective therapeutic strategies for delaying or inhibiting the spread of lung metastasis from the primary OS site are lacking. Hence, i...

Haoran Kong, Wenhui Yu, Zhuning Chen, Haonan Li, Guiwen Ye… in Cancer Cell International (2021)

Article

ZIP10 drives osteosarcoma proliferation and chemoresistance through ITGA10-mediated activation of the PI3K/AKT pathway

The zinc transporters Zrt- and Irt-related protein (ZIP/SLC39) are overexpressed in human tumors and correlate with poor prognosis; however, their contributions to carcinogenesis and chemoresistance in osteosa...

Hongyu Li, **n Shen, Mengjun Ma, Wenzhou Liu… in Journal of Experimental & Clinical Cancer … (2021)