33 Result(s)
within
Huixin **e
Biochemistry, general
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Article
CircABHD2 Inhibits Malignant Progression of Endometrial Cancer by Regulating NAD+/NAMPT Metabolism Axis
Circular RNAs (circRNAs) perform important functions in the regulation of diverse physiological and pathological processes. CircABHD2 exhibits down-regulation in both endometrial cancer (EC) cells and tissues,...
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Article
Vagus nerve electrical stimulation in the recovery of upper limb motor functional impairment after ischemic stroke
Ischemic stroke (IS) is characterized by high mortality, disability rates, and a high risk of recurrence. Motor dysfunction, such as limb hemiparesis, dysphagia, auditory disorders, and speech disorders, usual...
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Article
Open AccessYOD1 protects against MRSA sepsis-induced DIC through Lys33-linked deubiquitination of NLRP3
Disseminated intravascular coagulation (DIC) is considered to be the most common and lethal complication of sepsis. NLR-family pyrin domain-containing-3 (NLRP3) inflammasome plays an important role in host def...
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Article
Antibodies expand the scope of angiotensin receptor pharmacology
G-protein-coupled receptors (GPCRs) are key regulators of human physiology and are the targets of many small-molecule research compounds and therapeutic drugs. While most of these ligands bind to their target ...
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Article
Testicular Toxicity in Rats Exposed to AlCl3: a Proteomics Study
Aluminum contamination is a growing environmental and public health concern, and aluminum testicular toxicity has been reported in male rats; however, the underlying mechanisms of this toxicity are unclear. Th...
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Article
Cuproptosis-Related Gene Signature Contributes to Prognostic Prediction and Immunosuppression in Multiple Myeloma
Cuproptosis is a type of programmed cell death triggered by accumulation of intracellular copper which was considered closely related to tumor progression. The study of cuproptosis in multiple myeloma (MM) is ...
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Article
Enhancement of the organic acid content and antioxidant capacity of yellow whey through fermentation with Lacticaseibacillus casei YQ336
Fermentation is considered an effective tool for improving the functional characteristics of food. In this study, Lacticaseibacillus casei YQ336 was used to ferment yellow whey, and physical and chemical analysis...
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Article
Optical Temperature Sensing Based on Linear Change of Luminescence Intensity Ratio in Y2O3: Tm3+, Eu3+ Phosphors
In this work, Y2O3: Tm3+, Eu3+ phosphors were made by homogeneous precipitation with urea as precipitator. The emission spectra varying with temperature of Y2O3: Tm3+, Eu3+ phosphors were measured and analyzed. A...
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Article
Peptidomic Analysis and Potential Bioactive Peptides Identification Targeting Endometrial Cancer
Existing evidence has explained the critical role of endogenous peptides in cancers, however, the peptidomic profile and function involved in endometrial carcinoma (EC) is still unknown. Here we aim to charact...
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Article
Exploring the diagnostic value, prognostic value, and biological functions of NPC gene family members in hepatocellular carcinoma based on a multi-omics analysis
Liver cancer is a cunning malignancy with a high incidence and mortality rate among cancers worldwide. The NPC gene family members (NPCs: NPC1, NPC2, and NPC1L1) are closely linked to the development of multip...
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Article
Hair Selenium of Residents in Keshan Disease Endemic and Non-endemic Regions in China
Few nationwide investigations on hair selenium (Se) and Keshan disease (KD) have been conducted. KD is closely associated with Se deficiency. Hair Se is an important biomarker for selenium nutrition. This rese...
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Article
Boosting the electrochemiluminescence of luminol-O2 system by high-intensity focused ultrasound
Electrochemiluminescence (ECL) of luminol is a well-established methodology in analytical chemistry and bioimaging. Develo** novel strategies to enhance the ECL signal of this model emitter is a challenging ...
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Article
Open AccessGalectin-3 critically mediates the hepatoprotection conferred by M2-like macrophages in ACLF by inhibiting pyroptosis but not necroptosis signalling
We previously documented that M2-like macrophages exert a hepatoprotective effect in acute-on-chronic liver failure (ACLF) by inhibiting necroptosis signalling. Nevertheless, the molecular mechanism behind thi...
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Article
Nano-hybrid luminophores of Ti3C2TX quantum dots-gold nanoparticles based on in situ generation for sensitive electrochemiluminescence biosensing
Nanomaterial-derived quantum dots (QDs) are excellent electrochemiluminescence (ECL) luminophores and play an important role in optical sensing due to their excellent water solubility, good biocompatibility an...
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Article
Anchoring luminol based on Ti3C2-mediated in situ formation of Au NPs for construction of an efficient probe for miRNA electrogenerated chemiluminescence detection
An efficient electrogenerated chemiluminescence (ECL) nanoprobe (luminol-Au NPs-Ti3C2) was constructed based on Ti3C2Tx MXene (Ti3C2)-mediated in situ formation of Au NPs and anchoring luminol to fabricate a sens...
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Article
Methods used for the measurement of blood-brain barrier integrity
The blood-brain barrier (BBB) comprises the interface between blood, brain and cerebrospinal fluid. Its primary function, which is mainly carried out by tight junctions, is to stabilize the tightly controlled ...
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Article
A far-red hybrid voltage indicator enabled by bioorthogonal engineering of rhodopsin on live neurons
Membrane potential is a key aspect of cellular signalling and is dynamically regulated by an array of ion-selective pumps and channels. Fluorescent voltage indicators enable non-invasive optical recording of t...
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Article
Recent progress on bio-succinic acid production from lignocellulosic biomass
Succinic acid is a valuable bulk chemical, which has been extensively applied in food, medicine, surfactants and biodegradable plastics industries. As a substitute for chemical raw material, bio-based succinic...
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Article
Open AccessMicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents
Molecular targeted agents, such as sorafenib, remain the only choice of an antitumor drug for the treatment of advanced hepatocellular carcinoma (HCC). The Notch signaling pathway plays central roles in regula...
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Article
An integrated strategy to identify genes responsible for sesquiterpene biosynthesis in turmeric
Metabolic module, gene expression pattern and PLS modeling were integrated to precisely identify the terpene synthase responsible for sesquiterpene formation. Functional characterization confirmed the feasibil...
