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  1. No Access

    Article

    CAR directs T cell adaptation to bile acids in the small intestine

    Bile acids are lipid-emulsifying metabolites synthesized in hepatocytes and maintained in vivo through enterohepatic circulation between the liver and small intestine1. As detergents, bile acids can cause toxicit...

    Mei Lan Chen, **angsheng Huang, Hongtao Wang, Courtney Hegner, Yu** Liu… in Nature (2021)

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    Article

    Bcl-6 is the nexus transcription factor of T follicular helper cells via repressor-of-repressor circuits

    T follicular helper (TFH) cells are a distinct type of CD4+ T cells that are essential for most antibody and B lymphocyte responses. TFH cell regulation and dysregulation is involved in a range of diseases. Bcl-6...

    **yong Choi, Huitian Diao, Caterina E. Faliti, Jacquelyn Truong… in Nature Immunology (2020)

  3. No Access

    Article

    A reversible RNA on-switch that controls gene expression of AAV-delivered therapeutics in vivo

    Widespread use of gene therapy technologies is limited in part by the lack of small genetic switches with wide dynamic ranges that control transgene expression without the requirement of additional protein com...

    Guocai Zhong, Haimin Wang, Wenhui He, Yujun Li, Huihui Mou… in Nature Biotechnology (2020)

  4. No Access

    Article

    Interleukin-6 promotes systemic lupus erythematosus progression with Treg suppression approach in a murine systemic lupus erythematosus model

    Our aim is to reveal the role of interleukin 6 (IL-6) in the pathogenesis of systemic lupus erythematosus (SLE) in a murine model of SLE. Normal female C57BL/6 mice were immunized with syngeneic-activated lymp...

    **aoli Mao, Yunyun Wu, Huitian Diao, Jianlei Hao, Gaofei Tian… in Clinical Rheumatology (2014)