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  1. Article

    Open Access

    mTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA

    Osteosarcoma (OS) is considered a sex steroid hormone-dependent bone tumor. The development and progression of OS are regulated by 17β-estradiol (E2). However, the detailed mechanisms of E2-modulated OS progre...

    Zhengming Yang, Wei Yu, Ankai Xu, Bing Liu, Libin **, Huimin Tao… in Cell Death Discovery (2024)

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  2. Article

    Open Access

    Escin induces caspase-dependent apoptosis and autophagy through the ROS/p38 MAPK signalling pathway in human osteosarcoma cells in vitro and in vivo

    Osteosarcoma is one of the most malignant neoplasms in adolescents, and it generally develops multidrug resistance. Escin, a natural mixture of triterpene saponins isolated from Aesculus hippocastanum (horse c...

    Jian Zhu, Wei Yu, Bing Liu, Yitian Wang, Jianlin shao, Junjie Wang… in Cell Death & Disease (2017)

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