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Open AccessAnti-CD166/4-1BB chimeric antigen receptor T cell therapy for the treatment of osteosarcoma
Chimeric antigen receptor (CAR)-engineered T cells have displayed outstanding performance in the treatment of patients with hematological malignancies. However, their efficacy against solid tumors has been lar...
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Article
Open AccessmTORC1 accelerates osteosarcoma progression via m6A-dependent stabilization of USP7 mRNA
Osteosarcoma (OS) is considered a sex steroid hormone-dependent bone tumor. The development and progression of OS are regulated by 17β-estradiol (E2). However, the detailed mechanisms of E2-modulated OS progre...