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Article
Open AccessPredicted \(\var** _b(6087)^0\) and further predictions
The methods of QCD sum rules and light-cone sum rules within the framework of heavy quark effective theory have been widely applied to study the singly heavy baryons, and especially, we have applied these meth...
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Article
α-Synuclein Induced the Occurrence of RBD via Interaction with OX1R and Modulated Its Degradation
Rapid eye movement (REM) sleep behavior disorder (RBD) is a powerful early sign of Parkinson’s disease (PD), but the pathogenetic mechanism involved in RBD remains largely unexplored. α-Synuclein has been veri...
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Article
Blocked metabotropic glutamate receptor 5 enhances chemosensitivity in hepatocellular carcinoma and attenuates chemotoxicity in the normal liver by regulating DNA damage
DNA damaging agents are used as chemotherapeutics in many cancers, including hepatocellular carcinoma (HCC). However, they are associated with problems such as low sensitivity to chemotherapy and the induction...
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Article
Terminal ileum is the most sensitive site for the histologic diagnosis of grade 4 graft-versus-host disease (GvHD) in the lower GI tract and is a harbinger of poor outcome
The site of the gastrointestinal (GI) tract where biopsies are most likely to be diagnostic of graft-versus-host disease (GvHD) remains controversial. Recent reports have indicated that biopsies from the recto...
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Article
Open AccessMicroRNA-497 induced by Clonorchis sinensis enhances the TGF-β/Smad signaling pathway to promote hepatic fibrosis by targeting Smad7
Various stimuli, including Clonorchis sinensis infection, can cause liver fibrosis. Liver fibrosis is characterized by the activation of hepatic stellate cells (HSCs) with massive production of extracellular matr...
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Article
Assessment of Anti-Mullerian Hormone and Anti-Mullerian Hormone Type II Receptor Variants in Women with Repeated Implantation Failures
Repeated implantation failure (RIF) is a common endocrine disease that causes female infertility and the etiology is unknown. The abnormal expression of key proteins and hormones at the maternal–fetal interfac...
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Article
Open AccessEfficacy and safety of berberine for dyslipidemia: study protocol for a randomized double-blind placebo-controlled trial
Dyslipidemia is a major risk factor for atherosclerotic cardiovascular disease and a leading cause of death worldwide. The clinical utility of commonly used lipid-lowering drugs such as statins and fibrates is...
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Article
Open AccessMetabotropic glutamate receptor 5 inhibits α-synuclein-induced microglia inflammation to protect from neurotoxicity in Parkinson’s disease
Microglia activation induced by α-synuclein (α-syn) is one of the most important factors in Parkinson’s disease (PD) pathogenesis. However, the molecular mechanisms by which α-syn exerts neuroinflammation and ...
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Article
Topography, morphology, and etiology of lymphocytic gastritis: a focus on celiac disease
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Article
Open AccessComprehensive landscape of extracellular vesicle-derived RNAs in cancer initiation, progression, metastasis and cancer immunology
Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally divided into exosomes and microvesicles on basis of their origination from the endosomal membrane or the plasma membrane,...
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Article
Topography, morphology, and etiology of lymphocytic gastritis: a single institution experience
Lymphocytic gastritis (LG) is an uncommon reaction pattern of gastric injury characterized by intraepithelial lymphocytosis of the surface foveolar epithelium and chronic inflammation in the lamina propria. It...
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Article
Open AccessExcited \(\varOmega _b\) baryons and fine structure of strong interaction
The heavy baryon system bounded by the strong interaction has a rich internal structure, so its mass spectra can have the fine structure similar to the line spectra of atom bounded by the electromagnetic inter...
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Article
Open AccessDecay properties of P-wave bottom baryons within light-cone sum rules
We use the method of light-cone sum rules to study decay properties of P-wave bottom baryons belonging to the SU(3) flavor \(\mathbf {6}_F\)6F representation. In Cui et al. (Phys Rev D 99:094021, 2019) we have st...
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Article
Anti-Müllerian Hormone Regulates Stem Cell Factor via cAMP/PKA Signaling Pathway in Human Granulosa Cells by Inhibiting the Phosphorylation of CREB
Anti-Müllerian hormone (AMH) downregulates the level of stem cell factor (SCF) via the cAMP/PKA signaling pathway in human granulosa cells (GCs). Little information is available on the molecular mechanism unde...
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Article
Open AccessAn association between crypt apoptotic bodies and mucosal flattening in celiac disease patients exposed to dietary gluten
Celiac disease (CD) is characterized histologically by inflammation and villous atrophy. Villous atrophy is thought to result from a disruption of epithelial cellular proliferation and death. Epithelial cells ...
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Article
PDZ Scaffold Protein CAL Couples with Metabotropic Glutamate Receptor 5 to Protect Against Cell Apoptosis and Is a Potential Target in the Treatment of Parkinson’s Disease
Targeting mGluR5 has been an attractive strategy to modulate glutamate excitotoxicity for neuroprotection. Although human clinical trials using mGluR5 negative allosteric modulators (NAMs) have included some d...
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Article
Open AccessQCD sum rule studies of \(s s {\bar{s}} {\bar{s}}\) tetraquark states with \(J^{PC} = 1^{+-}\)
We apply the method of QCD sum rules to study the structure X newly observed by the BESIII Collaboration in the \(\phi \eta ^\prime \)
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Article
Hydrogen Production Using “Direct-Starting” Biocathode Microbial Electrolysis Cell and the Analysis of Microbial Communities
In this study, a “direct-starting” procedure was used to activate a single-chamber biocathode microbial electrolysis cell (MEC) and the development of a biocathode was studied through output current curves and...
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Article
Open AccessAssociation between increased serum alkaline phosphatase and the coronary slow flow phenomenon
Despite marked advances in our understanding of the pathophysiology of the coronary slow flow phenomenon (CSFP), the exact mechanism remains unclear. Previous studies have suggested that CSFP might be associat...
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Article
Open AccessUrate inhibits microglia activation to protect neurons in an LPS-induced model of Parkinson’s disease
Multiple risk factors contribute to the progression of Parkinson’s disease, including oxidative stress and neuroinflammation. Epidemiological studies have revealed a link between higher urate level and a lower...
