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Article
Open AccessPsychological status and behavior changes of the public during the COVID-19 epidemic in China
A cluster of pneumonia cases were reported by Wuhan Municipal Health Commission, China in December 2019. A novel coronavirus was eventually identified, and became the COVID-19 epidemic that affected public hea...
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Article
Expression of β1,3-N-acetylglucosaminyltransferases during differentiation of human acute myeloid leukemia cells
The expressions of β1,3-N-acetylglucosamonyltransferase-2 and -8 (β3GnT-2, β3GnT-8),—the two main glycosyltransferases responsible for the synthesis of poly-N-acetyllactosamine (polyLacNAc) in glycans, and β3GnT-...
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Chapter and Conference Paper
Lewis Glyco-Epitopes: Structure, Biosynthesis, and Functions
The Lewis glyco-epitope, also called the Lewis antigen (Le), is a series of α1→3/α1→4 fucosylated oligosaccharide epitopes derived from the Galβ1→3/1→4GlcNAcβ1→R carbohydrate backbone and that have been identi...
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Article
A new cis-platinum analog Pt(HPIP)Cl2: Its interaction with mononucleotides
A novel cis-platinum analog Pt(HPIP)Cl2 (HPIP = 2-(2-hydroxyphenyl)imidazo[4, 5-f] [1, 10]phenanethroline) has been synthesized and characterized. NMR and UV experiments show that the complex can interact with mo...
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Article
α1,3 Fucosyltransferase-VII modifies the susceptibility of apoptosis induced by ultraviolet and retinoic acid in human hepatocarcinoma cells
The role of α1,3fucosyltransferase-VII (α1,3 FucT-VII) in cell apoptosis was studied in human hepatocellular carcinoma H7721 cells. After the cells were transfected with α1,3 FucT-VII cDNA, the expression of a...
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Article
Expressions of polypeptide: N-acetylgalactosaminyltransferase in leukemia cell lines during 1,25-dihydroxyvitamin D3 induced differentiation
The effect of 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] on two leukemia cell lines, K562 and SHI-1, and its relation to the expression of different subtypes of polypeptide: N-acetylgalactosaminyltransferase (pp-GalN...
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Article
Down regulation of N-acetylglucosaminyltransferase V facilitates all-transretinoic acid to induce apoptosis of human hepatocarcinoma cells
After N-acetylglucosaminyltransferase V (GnT-V) activity was down-regulated by the transfection of its antisense cDNA(GnTV-AS), apoptosis of H7721 cells was appeared and the apoptosis induced by 80μM all-transret...
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Article
Blocking of N-acetylglucosaminyltransferase V induces cellular endoplasmic reticulum stress in human hepatocarcinoma 7721 cells
N-acetylglucosaminyltransferase V (GnT-V) is an important tumorigenesis and metastasis-associated enzyme. To study its biofunction, the GnT-V stably suppressed cell line (GnT-V-AS/7721) was constructed from 77...
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Article
Relations of the type and branch of surface N-glycans to cell adhesion, migration and integrin expressions
The relations between the structure of cell surface N-glycans to cell behaviors were studied in H7721 human hepatocarcinoma cell line, which predominantly expressed complex-type N-glycans on the surface. 1-Deo...
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Article
Forskolin up-regulates metastasis-related phenotypes and molecules via protein kinase B, but not PI-3K, in H7721 human hepato-carcinoma cell line
Forskolin (FSK) is known as an up-regulator of intracellular cAMP and inhibitor of cancer growth and metastasis. The effects of FSK on the metastasis potential and its mechanisms were studied using a human hep...
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Article
Alteration in N-acetylglucosaminyltransferase activities and glycan structure in tissue and bile glycoproteins from extrahepatic bile duct carcinoma
The activities of three N-acetylglucosaminyltransferases (GnT)-III, IV and V, as well as the structural alterations of N-glycans on the glycoproteins in cancer tissues and bile specimens from 28 cases of extrahep...
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Article
Structural alterations of sugar chains in urine fibronectin from bladder cancer patients and its enzymatic mechanism
Purpose: To study the structural alterations of asparagine-linked sugar chains (N-glycans) on urine fibronectin (Fn) from bladder cancer (BCa) patients and its enzymatic mechanism. Methods: Eight pairs of urine ...
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Article
Relationship between metastasis-associated phenotypes and N-glycan structure of surface glycoproteins in human hepatocarcinoma cells
Purpose: To study the relation of N-glycan structure on cell surface glycoproteins to the metastatic phenotypes. Methods: Two human hepatocarcinoma 7721 cell lines transfected with sense or antisense cDNA of GnT...
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Article
Modulation of the basal activity of N-acetylglucosaminyltransferase V by phosphatidylinositol-3-kinase/protein kinase B signaling pathway in human hepatocarcinoma cells
The modulation of GnT-V activity by signaling molecules in PI-3-K/PKB pathway in human hepatocarcinoma cell line 7721 was studied. GnT-V activity was determined after the transfection of sense or antisense cDN...
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Article
Effects of H-ras and v-sis overexpression on N-acetylglucosaminyltransferase V and metastasis-related phenotypes in human hepatocarcinoma cells
Oncogenes and N-acetylglucosaminyltransferase (GnT-V) are both commonly associated with carcinogenesis and metastasis. In order to elucidate the relationship between oncogenes and GnT-V, two oncogenes, H-ras and...
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Article
Regulation of phospholipase D from human hepatocarcinoma cell line by purine nucleotides and protein kinase A
The regulation of phosphatidylcholine-specific phospholipase D by purine nucleotides and protein kinase A were studied in vitro using an enzyme preparation partially purified from the membranous fraction of 7721 ...
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Article
Effects of all-trans retinoic acid and epidermal growth factor on the expression of nm23-H1 in human hepatocarcinoma cells
The effects of all-trans retinoic acid (ATRA) and epidermal growth factor (EGF) on the expression of nm23-H1, a metastasis suppressor gene, were studied in a human 7721 hepatocarcinoma cell line. It was discover...
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Article
Alteration of N-acetylglucosaminyltransferases in pancreatic carcinoma
The activities of three N-acetylglucosaminyltransferases ( GnT III, GnT IV and GnT V ) were determined in 10 samples of pancreatic carcinoma (PCa) and compared with those in 9 samples of normal pancreatic tiss...
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Article
Changes inN-acetylglucosaminyltransferase III, IV and V in renal cell carcinoma
The activities ofN-acetylglucosaminyltransferase (GnT) III, IV and V were determined in 10 cases of renal cell carcinoma (RCC) and compared with the normal kidney cortex (NKC) regions of the same kidney resected ...
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Article
Regulation ofN-acetylglucosaminyltransferase V by protein kinases
When 7721 human hepatocarcinoma cells were treated with 100nm phorbol-12-myristate-13-acetate (PMA), the activity ofN-acetylglucosaminyltransferase V(GnT-V) in the cells varied in accordance with the activity of ...
