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    Amino acids downregulate SIRT4 to detoxify ammonia through the urea cycle

    Ammonia production via glutamate dehydrogenase is inhibited by SIRT4, a sirtuin that displays both amidase and non-amidase activities. The processes underlying the regulation of ammonia removal by amino acids ...

    Song-Hua Hu, Yu-Yang Feng, Yuan-**n Yang, Hui-Da Ma, Shu-**an Zhou… in Nature Metabolism (2023)