17 Result(s)

Article

MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis

Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of ...

Yangyang Ding, **ang Gui, **ang Chu, Yueyue Sun, Sixuan Zhang… in Nature Communications (2023)

Article

Atypical cholangiocytes derived from hepatocyte-cholangiocyte transdifferentiation mediated by COX-2: a kind of misguided liver regeneration

Hepatocyte-cholangiocyte transdifferentiation (HCT) is a potential origin of proliferating cholangiocytes in liver regeneration after chronic injury. This study aimed to determine HCT after chronic liver injur...

Tian Lan, Yang Tai, Chong Zhao, Yang **ao, Zhu Yang… in Inflammation and Regeneration (2023)

Article

Correction: Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats

**-Hang Gao, Shi-Lei Wen, Shi Feng, Wen-Juan Yang, Yao-Yao Lu, Huan Tong… in Angiogenesis (2023)

Article

The effectiveness of travel restriction measures in alleviating the COVID-19 epidemic: evidence from Shenzhen, China

With the expansion of the global novel coronavirus disease (COVID-19) pandemic, unprecedented interventions have been widely implemented in many countries, including China. In view of this scenario, this resea...

Honglu Ji, Huan Tong, **gge Wang, Dan Yan… in Environmental Geochemistry and Health (2022)

Article

Does Monitoring Total and Free Polymyxin B1 Plasma Concentrations Predict Polymyxin B-Induced Nephrotoxicity? A Retrospective Study in Critically Ill Patients

The correlation between total and free polymyxin B (PMB including PMB1 and PMB2) exposure in vivo and acute kidney injury (AKI) remains obscure. This study explores the relationships between plasma exposure of...

Yang Deng, Jun-Yuan Gu, **n Li, Huan Tong, Si-Wei Guo… in Infectious Diseases and Therapy (2022)

Article

Author Correction: Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer

**-Hang Gao, Chun-Hui Wang, Huan Tong, Shi-Lei Wen, Zhi-Yin Huang… in Scientific Reports (2022)

Article

Dimethyl fumarate inhibits antibody-induced platelet destruction in immune thrombocytopenia mouse

Immune thrombocytopenia (ITP) is an autoimmune disease characterized as a low platelet count resulting from immune-mediated platelet destruction. Dimethyl fumarate (DMF) is widely applied for the treatment of ...

Huan Tong, Yangyang Ding, **ang Gui, Zengtian Sun, Guozhang Wang… in Thrombosis Journal (2021)

Article

The impacts of acid suppression on duodenal microbiota during the early phase of severe acute pancreatitis

Duodenal dysbiosis may be potential infection risks in patients with severe acute pancreatitis (SAP). Acid-suppression drugs (ACDs) are widely used in SAP patients in Asian countries. However, the impact of AC...

**ao Ma, Libin Huang, Zhiyin Huang, **sun Jiang, Chong Zhao… in Scientific Reports (2020)

Article

Autocrine motility factor promotes endometrial cancer progression by targeting GPER-1

Autocrine motility factor (AMF) is a critical factor regulating aggressiveness of endometrial cancer (EC). Multiple pieces of evidence indicate that it is through G protein coupled estrogen receptor (GPER) sig...

Yiran Li, Yuanhui Jia, Yiding Bian, Huan Tong… in Cell Communication and Signaling (2019)

Article

Obesity Aggravates Acute Pancreatitis via Damaging Intestinal Mucosal Barrier and Changing Microbiota Composition in Rats

Obesity may aggravate acute pancreatitis (AP) through damaging the intestinal mucosal barrier (IMB). The underlying mechanism remains unclear. This study was aimed to provide further data to clarify the mechan...

Cheng Ye, Ling Liu, **ao Ma, Huan Tong, **hang Gao, Yang Tai… in Scientific Reports (2019)

Article

Comparison of prognostic, clinical, and renal histopathological characteristics of overlap** idiopathic membranous nephropathy and IgA nephropathy versus idiopathic membranous nephropathy

Overlap** idiopathic membranous nephropathy (IMN) and immunoglobulin A nephropathy (IgAN) is rare. This study aims to investigate the unique prognostic, clinical, and renal histopathological characteristics ...

**nxin Chen, Yu Chen, Keqing Shi, Yinqiu Lv, Huan Tong, Guangju Zhao… in Scientific Reports (2017)

Article

Loss of Polycomb Group Protein Pcgf1 Severely Compromises Proper Differentiation of Embryonic Stem Cells

The Polycomb repressive complex 1 (PRC1) is essential for fate decisions of embryonic stem (ES) cells. Emerging evidence suggests that six major variants of PRC1 complex, defined by the mutually exclusive pres...

Yun Yan, Wukui Zhao, Yikai Huang, Huan Tong, Yin **a, Qing Jiang… in Scientific Reports (2017)

Article

Collapsed Reticular Network and its Possible Mechanism during the Initiation and/or Progression of Hepatic Fibrosis

Among the researches on hepatic fibrosis, great attention was paid to both hepatocytes and extracellular matrix (ECM). However, little focus was drawn on reticular fibrous network, which is important for demar...

Shi-Lei Wen, Shi Feng, Shi-Hang Tang, **-Hang Gao, Lin-hao Zhang… in Scientific Reports (2016)

Article

Celecoxib and octreotide synergistically ameliorate portal hypertension via inhibition of angiogenesis in cirrhotic rats

Abnormal angiogenesis is critical for portal hypertension in cirrhosis. Except for etiological treatment, no efficient medication or regime has been explored to treat the early stage of cirrhosis when angiogen...

**-Hang Gao, Shi-Lei Wen, Shi Feng, Wen-Juan Yang, Yao-Yao Lu, Huan Tong… in Angiogenesis (2016)

Article

Prostaglandin E2 (PGE2) promotes proliferation and invasion by enhancing SUMO-1 activity via EP4 receptor in endometrial cancer

Prostaglandin E2 (PGE2), a derivative of arachidonic acid, has been identified as a tumorigenic factor in many cancers in recent studies. Prostaglandin E synthase 2 (PTGES2) is an enzyme that in humans is enco...

Jieqi Ke, Yixia Yang, Qi Che, Feizhou Jiang, Huihui Wang, Zheng Chen… in Tumor Biology (2016)

Article

Targeting inhibition of extracellular signal-regulated kinase kinase pathway with AZD6244 (ARRY-142886) suppresses growth and angiogenesis of gastric cancer

AZD6244 (ARRY-142886), a highly selective MAPK-ERK kinase inhibitor, has shown excellent clinical efficacy in many tumors. However, the anti-tumor and anti-angiogenesis efficacy of AZD6244 on gastric cancer ha...

**-Hang Gao, Chun-Hui Wang, Huan Tong, Shi-Lei Wen, Zhi-Yin Huang… in Scientific Reports (2015)

Article

Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice

Liver X receptor (LXR) plays a critical regulatory role in metabolism and inflammation, and has been demonstrated to be involved in cardiovascular physiology/pathology. In the present study, we investigated th...

Qing He, Jun Pu, Ancai Yuan, Tianbao Yao, **aoying Ying… in Cardiovascular Diabetology (2014)