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Article
Open AccessWZ-3146 acts as a novel small molecule inhibitor of KIF4A to inhibit glioma progression by inducing apoptosis
Glioma is considered the most common primary malignant tumor of the central nervous system. Although traditional treatments have not achieved satisfactory outcomes, recently, targeted therapies for glioma have...
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Article
Open AccessMulti-cohort study on cytokine and chemokine profiles in the progression of COVID-19
Various substances in the blood plasma serve as prognostic indicators of the progression of COVID-19. Consequently, multi-omics studies, such as proteomic and metabolomics, are ongoing to identify accurate bio...
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Article
Influence of Net Do** Concentration on Carrier Lifetime in 4H-SiC Substrates
Lightly nitrogen-doped (N-doped) and vanadium-doped (V-doped) 4H-SiC single crystals grown by physical vapor transport were used to investigate the effect of net do** concentration on carrier lifetime. The c...
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Article
Characterization and modeling of the uniaxial thermo-mechanical compressive behavior of polymethacrylimide (PMI) foam at different temperatures
This paper investigates the uniaxial compressive failure behavior of polymethacrylimide (PMI) foam across a range of temperatures (20 °C–200 °C), at both macro- and microscales. The investigation includes dyna...
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Article
Open AccessProteomics and phosphoproteomics to study Tuina reverses capsule fibrosis in frozen shoulder: a research report based on rats
Frozen shoulder (FS) is a common disorder often treated with Tuina, but the mechanisms involved remain unclear. We employed proteomics and phosphoproteomics to investigate the mechanisms associated with the tr...
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Article
Open AccessThe creation and validation of predictive models to assess the risk of unfavorable outcomes following hybrid total arch repair for Stanford type A aortic dissection
The objective of this study was to develop and validate a nomogram for the individualized prediction of adverse events in patients with Stanford type A aortic dissection (TAAD) undergoing hybrid total aortic a...
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Article
Fabrication of graphene-assisted voltammetry platform for the detection of nitrate ions in PM2.5
This study presents the fabrication and application of a graphene-assisted voltammetry platform for the sensitive detection of nitrate ions in PM2.5 (atmospheric aerosols with a maximum diameter of 2.5 µm). Th...
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Article
Open AccessStructural basis of nucleosome deacetylation and DNA linker tightening by Rpd3S histone deacetylase complex
In Saccharomyces cerevisiae, cryptic transcription at the coding region is prevented by the activity of Sin3 histone deacetylase (HDAC) complex Rpd3S, which is carried by the transcribing RNA polymerase II (RNAPI...
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Article
Sam68 promotes osteogenic differentiation of aortic valvular interstitial cells by TNF-α/STAT3/autophagy axis
Calcified aortic valve disease (CAVD) is a major non-rheumatic heart valve disease in the world, with a high mortality rate and without suitable pharmaceutical therapy due to its complex mechanisms. Src-associ...
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Article
Structural genomics of the human dopamine receptor system
The dopaminergic system, including five dopamine receptors (D1R to D5R), plays essential roles in the central nervous system (CNS); and ligands that activate dopamine receptors have been used to treat many neu...
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Article
Open AccessIntegrated analysis of how gender and body weight affect the intestinal microbial diversity of Gymnocypris chilianensis
Intestinal microorganisms that living in the mucosa and contents of the gastrointestinal tract of animals, have close links with their hosts over a long evolutionary history. The community structure of the fis...
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Article
Open AccessTargeting copper death genoty** associated gene RARRES2 suppresses glioblastoma progression and macrophages infiltration
Copper homeostasis is associated with malignant biological behavior in various tumors. The excessive accumulation of copper can induce tumor death, which is named cuproptosis, and it is also closely related to...
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Article
Open AccessResearch progress of large size SiC single crystal materials and devices
SiC semiconductor is the focus of recent international research. It is also an important raw material for China to achieve carbon emission peak and carbon neutrality. After nearly 20 years of research and deve...
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Article
Discriminative-region attention and orthogonal-view generation model for vehicle re-identification
Vehicle re-identification (Re-ID) is urgently demanded to alleviate the pressure caused by the increasingly onerous task of urban traffic management. Multiple challenges hamper the applications of vision-based...
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Article
Integrated analysis of the miRNA and mRNA expression profiles in Leiocassis longirostris at gonadal maturation
Leiocassis longirostris is a commercially important fish species that shows a sexually dimorphic growth pattern. A lack of molecular data from the gonads of this species has hindered research and selective breedi...
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Article
Open AccessThe Effects of ATIR Blocker on the Severity of COVID-19 in Hypertensive Inpatients and Virulence of SARS-CoV-2 in Hypertensive hACE2 Transgenic Mice
Angiotensin-converting enzyme 2 (ACE2) is required for the cellular entry of the severe acute respiratory syndrome coronavirus 2. ACE2, via the Ang-(1-7)-Mas-R axis, is part of the antihypertensive and cardiop...
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Chapter and Conference Paper
Autonomous Aerial Recovery System of a Compound Mother-Daughter UAV System
Micro aerial vehicles (MAVs) are usually chosen as daughter-UAVs for many complicated missions in mother-daughter UAV system, and their recovery method is significant for the coordination between mother-UAV an...
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Article
Integrative analysis identifies the quality advantage and corresponding regulatory mechanism of paddy field–cultured crayfish (Procambarus clarkii)
Procambarus clarkii is the dominant economic variety of crayfish in China, and paddy field shrimp cultivation is an organic mode of traditional rice-fish cultivation, with paddy field shrimp being the country’s p...
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Article
Open AccessSARS-CoV-2 infection induces sustained humoral immune responses in convalescent patients following symptomatic COVID-19
Long-term antibody responses and neutralizing activities in response to SARS-CoV-2 infection are not yet clear. Here we quantify immunoglobulin M (IgM) and G (IgG) antibodies recognizing the SARS-CoV-2 recepto...
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Article
Open AccessANDC: an early warning score to predict mortality risk for patients with Coronavirus Disease 2019
Patients with severe Coronavirus Disease 2019 (COVID-19) will progress rapidly to acute respiratory failure or death. We aimed to develop a quantitative tool for early predicting mortality risk of patients wit...
