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Article
Open AccessTargeting the NAT10/NPM1 axis abrogates PD-L1 expression and improves the response to immune checkpoint blockade therapy
PD-1/PD-L1 play a crucial role as immune checkpoint inhibitors in various types of cancer. Although our previous study revealed that NPM1 was a novel transcriptional regulator of PD-L1 and stimulated the trans...
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Article
Open AccessA comparison of traditional plant knowledge between Daman people and Tibetans in Gyirong River Valley, Tibet, China
By comparing the differences in plant use between various cultures or regions, we can gain a better understanding of traditional knowledge of plant use among different groups, which may lead to a more objectiv...
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Article
Open AccessCT-based deep learning model for the prediction of DNA mismatch repair deficient colorectal cancer: a diagnostic study
Stratification of DNA mismatch repair (MMR) status in patients with colorectal cancer (CRC) enables individual clinical treatment decision making. The present study aimed to develop and validate a deep learnin...
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Article
Open AccessAn ethnobotanical study on wild plants used by Tibetan people in Gyirong Valley, Tibet, China
Gyirong Valley known as the “Back Garden of the Himalayas” is located in the core area of the Everest National Nature Reserve. It is also one of the important ports from ancient Tibet to Kathmandu, Nepal, sinc...
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Article
Open AccessFirst-line pembrolizumab plus chemotherapy for extensive-stage small-cell lung cancer: a United States-based cost-effectiveness analysis
The clinical trial of Keynote-604 showed that pembrolizumab plus chemotherapy could generate clinical benefits for extensive-stage small-cell lung cancer (ES-SCLC). We aim to assess the efficacy and cost of pe...
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Article
Open AccessAdapting the DeepSARM approach for dual-target ligand design
The structure–activity relationship (SAR) matrix (SARM) methodology and data structure was originally developed to extract structurally related compound series from data sets of any composition, organize these...
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Article
Cost-Effectiveness Analysis of Encorafenib, Binimetinib, and Cetuximab in BRAF V600E-Mutated Metastatic Colorectal Cancer in the USA
Recently the phase 3 BEACON trial showed that the combination of encorafenib, cetuximab, and binimetinib versus cetuximab and irinotecan/FOLFIRI improved overall survival in pre-treated patients with metastati...
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Article
Open AccessEthnobotanical study on wild edible plants used by three trans-boundary ethnic groups in Jiangcheng County, Pu’er, Southwest China
Dai, Hani, and Yao people, in the trans-boundary region between China, Laos, and Vietnam, have gathered plentiful traditional knowledge about wild edible plants during their long history of understanding and u...
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Article
Efficacy and Safety of Regorafenib in Combination with Chemotherapy as Second-Line Treatment in Patients with Metastatic Colorectal Cancer: A Network Meta-Analysis and Systematic Literature Review
Although various therapies are available for the treatment of metastatic colorectal cancer (mCRC), there is lack of head-to-head evidence. Recent studies have demonstrated the efficacy of chemotherapy in combi...
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Article
Open AccessSimplified activity cliff network representations with high interpretability and immediate access to SAR information
Activity cliffs (ACs) consist of structurally similar compounds with a large difference in potency against their target. Accordingly, ACs introduce discontinuity in structure-activity relationships (SARs) and ...
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Article
Open AccessAdvances in exploring activity cliffs
The activity cliff (AC) concept is of comparable relevance for medicinal chemistry and chemoinformatics. An AC is defined as a pair of structurally similar compounds with a large potency difference against a g...
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Article
Cost-Effectiveness Analysis of Atezolizumab Plus Chemotherapy in the First-Line Treatment of Metastatic Non-Squamous Non-Small Cell Lung Cancer
The purpose of this study was to estimate the cost-effectiveness of atezolizumab plus chemotherapy in patients with metastatic non-squamous non-small cell lung cancer (NSCLC) from the United States (US) payers...
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Article
Open AccessNPM1 upregulates the transcription of PD-L1 and suppresses T cell activity in triple-negative breast cancer
Programmed cell death protein-1 (PD-1)/programmed cell death ligand-1 (PD-L1) interaction plays a crucial role in tumor-associated immune escape. Here, we verify that triple-negative breast cancer (TNBC) has h...
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Article
Open AccessCEA clearance pattern as a predictor of tumor response to neoadjuvant treatment in rectal cancer: a post-hoc analysis of FOWARC trial
The clinical factors that accurately predict the response to preoperative treatment in rectal cancer were yet unknown. The carcinoembryonic antigen (CEA) clearance pattern during neoadjuvant treatment has been...
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Article
Open AccessmiR-302b inhibits tumorigenesis by targeting EphA2 via Wnt/ β-catenin/EMT signaling cascade in gastric cancer
EphA2 is a crucial oncogene in gastric cancer (GC) development and metastasis, this study aims to identify microRNAs that target it and serve as key regulators of gastric carcinogenesis.
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Article
Open AccessApplication and comparison of different implanted ports in malignant tumor patients
The current study aims to compare the application and convenience of the upper arm port with the other two methods of implanted ports in the jugular vein and the subclavian vein in patients with gastrointestin...
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Article
Open AccessAn ethnobotanical study of the less known wild edible figs (genus Ficus) native to **shuangbanna, Southwest China
The genus Ficus, collectively known as figs, is a key component of tropical forests and is well known for its ethnobotanical importance. In recent decades an increasing number of studies have shown the indigenous...
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Article
Zircon U-Pb age and Hf isotopic characteristics of the Huangtuliang monzonitic granite, North Hebei Province, China
The Huangtuliang monzonitic granite outcrops on the northern side of the Huangtuliang gold mining district, Chicheng, North Hebei Province. Our predecessors only made isotopic age determination using the K-Ar ...
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Article
Impact of land use and land cover changes on ecosystem services in Menglun, **shuangbanna, Southwest China
Changing the landscape has serious environmental impacts affecting the ecosystem services, particularly in the tropics. In this paper, we report changes in ecosystem services in relation to land use and land c...
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Article
Helium-argon isotopic tracing for the Pb-Zn-Ag polymetallic ore deposits in the central-south segment of the Da Hinggan Ling Range
In recent years big strides have been made in the exploration of ores in the central-south segment of the Da Hinggan Ling Range, though some debates still exist on the metallogenesis and sources of ore-forming...
