37 Result(s)

Article

Transcription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma

Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients’ survival and became the first-line treatment for advanced nasopharyngeal carcinoma (NPC), not al...

Xue-Liang Fang, Qing-Jie Li, Jia-Yi Lin, Cheng-Long Huang… in Cell Death & Disease (2024)

Article

DNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation

Emerging evidence indicates that DNA methylation plays an important role in the initiation and progression of nasopharyngeal carcinoma (NPC). DNAJA4 is hypermethylated in NPC, while its role in regulating NPC ...

Qun Zhang, ** Feng, Xun-Hua Zhu, Shi-Qing Zhou, Ming-Liang Ye… in Cell Death & Disease (2023)

Article

Retraction Note: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2022)

Article

Mitofusins: from mitochondria to fertility

Germ cell formation and embryonic development require ATP synthesized by mitochondria. The dynamic system of the mitochondria, and in particular, the fusion of mitochondria, are essential for the generation of...

Shanjiang Zhao, Nuo Heng, Huan Wang, Haoyu Wang… in Cellular and Molecular Life Sciences (2022)

Article

The Impact of Quarantine and Medical Resources on the Control of COVID-19 in Wuhan based on a Household Model

In order to understand how Wuhan curbed the COVID-19 outbreak in 2020, we build a network transmission model of 123 dimensions incorporating the impact of quarantine and medical resources as well as household ...

Shanshan Feng, Ju** Zhang, Juan Li, … in Bulletin of Mathematical Biology (2022)

Article

MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma

N6-Methyladenosine (m6A) modification is the most abundant RNA modification in eukaryotic cells. IGF2BP3, a well-known m6A reader, is deregulated in many cancers, but its role in nasopharyngeal carcinoma (NPC)...

Mingyu Du, Yi Peng, Yang Li, Wenyue Sun, Huanfeng Zhu, **g Wu… in Cell Death Discovery (2022)

Article

MiR-135b-5p is an oncogene in pancreatic cancer to regulate GPRC5A expression by targeting transcription factor KLF4

KLF4 is implicated in tumor progression of pancreatic cancer, but the molecular regulatory mechanism of KLF4 needs to be further specified. We aimed to probe molecular regulatory mechanism of KLF4 in malignant...

Daren Liu, Yun **, **hong Wu, Huanbing Zhu, Dan Ye in Cell Death Discovery (2022)

Article

Modeling and Evaluation of the Joint Prevention and Control Mechanism for Curbing COVID-19 in Wuhan

The spread of COVID-19 in Wuhan was successfully curbed under the strategy of “Joint Prevention and Control Mechanism.” To understand how this measure stopped the epidemics in Wuhan, we establish a compartment...

Linhua Zhou, **nmiao Rong, Meng Fan, Liu Yang… in Bulletin of Mathematical Biology (2022)

Article

FDI-6 inhibits the expression and function of FOXM1 to sensitize BRCA-proficient triple-negative breast cancer cells to Olaparib by regulating cell cycle progression and DNA damage repair

Inducing homologous-recombination (HR) deficiency is an effective strategy to broaden the indications of PARP inhibitors in the treatment of triple-negative breast cancer (TNBC). Herein, we find that repressio...

Shu-** Wang, Shi-Qi Wu, Shi-Hui Huang, Yi-Xuan Tang… in Cell Death & Disease (2021)

Article

Smooth muscle-derived macrophage-like cells contribute to multiple cell lineages in the atherosclerotic plaque

Yi Li, Huan Zhu, Qianyu Zhang, **meng Han, Zhenqian Zhang, Linghong Shen… in Cell Discovery (2021)

Article

Sca1 marks a reserve endothelial progenitor population that preferentially expand after injury

Juan Tang, Huan Zhu, Shaoyan Liu, Haixiao Wang, **uzhen Huang, Yan Yan… in Cell Discovery (2021)

Article

DNA demethylase Tet2 suppresses cisplatin-induced acute kidney injury

Demethylase Tet2 plays a vital role in the immune response. Acute kidney injury (AKI) initiation and maintenance phases are marked by inflammatory responses and leukocyte recruitment in endothelial and tubular...

Yinwu Bao, Mengqiu Bai, Huanhuan Zhu, Yuan Yuan, Ying Wang… in Cell Death Discovery (2021)

Article

Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion remains elusive. Here, we show that cl...

Jiadi Lv, Zhenfeng Wang, Ya** Qu, Hua Zhu, Qiangqiang Zhu, Wei Tong… in Cell Discovery (2021)

Article

GBP5 drives malignancy of glioblastoma via the Src/ERK1/2/MMP3 pathway

Guanylate binding proteins (GBPs), a family of interferon-inducible large GTPase, play a pivotal role in cell-autonomous immunity and tumor malignant transformation. Glioblastoma (GBM) is the most prevalent an...

**aoting Yu, **g **, Yanwen Zheng, Hua Zhu, Hui Xu, Jun Ma… in Cell Death & Disease (2021)

Article

LncRNA TTN-AS1 promotes the progression of cholangiocarcinoma via the miR-320a/neuropilin-1 axis

Neuropilin-1 regulated by miR-320a participates in the progression of cholangiocarcinoma by serving as a co-receptor that activates multiple signaling pathways. The present study sought to investigate upstream...

Huaqiang Zhu, Bo Zhai, Changjun He, Ziyi Li, Hengjun Gao, Zheyu Niu… in Cell Death & Disease (2020)

Article

RETRACTED ARTICLE: Upregulation of OSBPL3 by HIF1A promotes colorectal cancer progression through activation of RAS signaling pathway

Oxysterol-binding protein like protein 3 (OSBPL3) has been shown involving in the development of several human cancers. However, the relationship between OSBPL3 and colorectal cancer (CRC), particularly the ro...

Hong-li Jiao, Bin-shu Weng, Shan-shan Yan, Zi-mo Lin, Shu-yang Wang… in Cell Death & Disease (2020)