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178 Result(s)
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Article
ANT2: the first mammalian mitochondrial RNA transport translocon
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Article
Aridity-driven divergence in soil microbial necromass carbon in alpine grasslands of the Tibetan Plateau
Soil microbial necromass carbon (MNC) contributes to the long-term stability of soil organic carbon (SOC). However, the response of MNC across aridity gradients remains unclear, especially in vulnerable alpine...
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Article
Open AccessDiversity Patterns of Eukaryotic Phytoplankton in the Medog Section of the Yarlung Zangbo River
As one of the important biodiversity conservation areas in China, the ecosystem in the lower reaches of the Yarlung Zangbo River is fragile, and is particularly sensitive to global changes. To reveal the diver...
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Article
Improve meat production and virus resistance by simultaneously editing multiple genes in livestock using Cas12iMax
The clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated gene (Cas) system is continually optimized to achieve the most efficient gene editing effect. The Cas12iMax, a Cas12i varia...
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Isolation and characterization of 48 SNP markers of sleepy cod, Oxyeleotris lineolata by whole-genome resequencing
The sleepy cod Oxyeleotris lineolata is native to northern Australia. At present, there is little information on the genome information of the sleepy cod. In this study, a total of 48 novel single nucleotide poly...
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Article
Purification and Characterization of a Novel Anticoagulant Peptide from Protein Hydrolysate of Eupolyphaga sinensis Walker
Eupolyphaga sinensis Walker (ESW), an animal drug in traditional Chinese medicine, has been used clinically for thousands of years for cardiovascular disease and osteoarthritis. Many studies of ESW have reported ...
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Article
Open AccessTranscription factor ATMIN facilitates chemoresistance in nasopharyngeal carcinoma
Despite that the docectaxel-cisplatin-5-fluorouracil (TPF) induction chemotherapy has greatly improved patients’ survival and became the first-line treatment for advanced nasopharyngeal carcinoma (NPC), not al...
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Open AccessThe temporal association of CapZ with early endosomes regulates endosomal trafficking and viral entry into host cells
Many viruses enter host cells by hijacking endosomal trafficking. CapZ, a canonical actin cap** protein, participates in endosomal trafficking, yet its precise role in endocytosis and virus infection remains...
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Open AccessIdentifying disease-related microbes based on multi-scale variational graph autoencoder embedding Wasserstein distance
Enormous clinical and biomedical researches have demonstrated that microbes are crucial to human health. Identifying associations between microbes and diseases can not only reveal potential disease mechanisms,...
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Article
Aphanochaete xiantaoensis sp. nov., a new member of green algal genus Aphanochaete (Chaetophoraceae, Chaetophorales) based on morphology and molecular phylogeny
The green algal genus Aphanochaete consists of species with uniseriate, simple, or irregularly branched, prostrate, and erect filaments, with cells bearing unsheathed unicellular hairs with or without bulbous bas...
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Article
Open AccessDNAJA4 suppresses epithelial-mesenchymal transition and metastasis in nasopharyngeal carcinoma via PSMD2-mediated MYH9 degradation
Emerging evidence indicates that DNA methylation plays an important role in the initiation and progression of nasopharyngeal carcinoma (NPC). DNAJA4 is hypermethylated in NPC, while its role in regulating NPC ...
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Open AccessActivation of MG53 Enhances Cell Survival and Engraftment of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Injured Hearts
Our previous studies demonstrated that MG53 protein can protect the myocardium, but its use as a therapeutic is challenging due to its short half-life in blood circulation. This study aimed to investigate the ...
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Article
Construction and application of a new watermelon germplasm with the phenotype of dwarf and branchless
Watermelon (Citrullus lanatus) is a widely cultivated cucurbitaceae crop appreciated by consumers worldwide. However, the long vine and abundant lateral branches of currently cultivated watermelon varieties hinde...
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Article
Natural allelic variation in the EamA-like transporter, CmSN, is associated with fruit skin netting in melon
A SNP mutation in CmSN, encoding an EamA-like transporter, is responsible for fruit skin netting in melon.
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Article
MiR-29c alleviates hyperglycemia-induced inflammation via targeting TGF-β in cardiomyocytes
This study aims to investigate whether miR-29c is involved in regulating transforming growth factor-β (TGF-β) mediated inflammation in diabetic cardiomyopathy (DCM). Our data showed increased inflammation and ...
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Article
Effects of saline immersion on the physiological alterations of grass goldfish (Carassius auratus) during subsequent recovery in freshwater
The present work aims to evaluate the tolerance, osmoregulation, metabolism, and antioxidant ability of saline water immersed grass goldfish (Carassius auratus) during the recovery in freshwater. Grass goldfish (...
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Article
A novel rat model of sarcopenic obesity based on aging and high-fat diet consumption
Sarcopenic obesity (SO) is defined as a combination of obesity and sarcopenia, leading to serious health consequences. However, a lack of suitable animal models has hampered research into this disorder. 12-mon...
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Article
Melon yellow-green plant (Cmygp) encodes a Golden2-like transcription factor regulating chlorophyll synthesis and chloroplast development
A SNP mutation in CmYGP gene encoding Golden2-like transcription factor is responsible for melon yellow-green plant trait.
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Article
Open AccessSirtuin 3 regulation: a target to alleviate β-hydroxybutyric acid-induced mitochondrial dysfunction in bovine granulosa cells
During the transition period, the insufficient dry matter intake and a sharply increased in energy consumption to produce large quantities of milk, high yielding cows would enter a negative energy balance (NEB...
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Factors associated with dysglycemia and its post-surgical resolution in patients with pheochromocytomas