58 Result(s)
within
Hongyan wang
Life Sciences
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Article
Deamidation enables pathogenic SMAD6 variants to activate the BMP signaling pathway
The BMP signaling pathway plays a crucial role in regulating early embryonic development and tissue homeostasis. SMAD6 encodes a negative regulator of BMP, and rare variants of SMAD6 are recurrently found in indi...
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Plasma-Derived Exosomal tRF-Phe-GAA-001 and tRF-Gly-GCC-037 as Novel Diagnostic Biomarkers for Cervical Cancer
This study delves into the exploration of exosomal transfer RNA-derived fragments (tRFs) as potential diagnostic markers for cervical cancer (CC). Employing plasma-derived exosomes isolated through ultracentri...
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Open AccessDUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response
Detection of cytosolic nucleic acids by pattern recognition receptors, including STING and RIG-I, leads to the activation of multiple signalling pathways that culminate in the production of type I interferons ...
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Open AccessJacalin-related lectin 45 (OsJRL45) isolated from ‘sea rice 86’ enhances rice salt tolerance at the seedling and reproductive stages
Rice (Oryza sativa L.) is one of the most widely cultivated grain crops in the world that meets the caloric needs of more than half the world’s population. Salt stress seriously affects rice production and threat...
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Anti-biofilm effect of salivary histatin 5 on Porphyromonas gingivalis
This study aimed to investigate the effects of salivary histatin 5 (Hst5) on Porphyromonas gingivalis (P. gingivalis) biofilms in vitro and in vivo and the possible mechanisms. In in vitro experiments, P. gingiva...
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Open AccessOocyte Arrested at Metaphase II Stage were Derived from Human Pluripotent Stem Cells in vitro
Initiation of meiosis is the most difficult aspect of inducing competent oocytes differentiation from human stem cells in vitro. Human induced pluripotent stem cells (hiPSCs) and embryonic stem cells (hESCs) were...
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Open AccessExcess folic acid intake increases DNA de novo point mutations
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Open AccessExogenous hydrogen sulfide and methylglyoxal alleviate cadmium-induced oxidative stress in Salix matsudana Koidz by regulating glutathione metabolism
Cadmium (Cd) is a highly toxic element for plant growth. In plants, hydrogen sulfide (H2S) and methylglyoxal (MG) have emerged as vital signaling molecules that regulate plant growth processes under Cd stress. Ho...
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Open AccessHuman endoderm stem cells reverse inflammation-related acute liver failure through cystatin SN-mediated inhibition of interferon signaling
Acute liver failure (ALF) is a life-threatening disease that occurs secondary to drug toxicity, infection or a devastating immune response. Orthotopic liver transplantation is an effective treatment but limite...
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Article
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways
Diabetes mellitus (DM) is a metabolic syndrome, caused by insufficient insulin secretion or insulin resistance (IR). DM enhances oxidative stress and induces mitochondrial function in different kinds of cell t...
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Open AccessOverexpression of AHL9 accelerates leaf senescence in Arabidopsis thaliana
Leaf senescence, the final stage of leaf growth and development, is regulated by numerous internal factors and environmental cues. Ethylene is one of the key senescence related hormones, but the underlying mol...
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Open AccessParental folate deficiency induces birth defects in mice accompanied with increased de novo mutations
Dietary folate deficiency (FD) is associated with the occurrence of birth defects. However, the mechanisms underlying this association remain elusive. In particular, how FD affects genome stability is unknown....
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Integrin αEβ7+ T cells direct intestinal stem cell fate decisions via adhesion signaling
Intestinal stem cell (ISC) differentiation is regulated precisely by a niche in the crypt, where lymphocytes may interact with stem and transient amplifying (TA) cells. However, whether and how lymphocyte–stem...
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Article
Overexpression of uracil permease and nucleoside transporter from Bacillus amyloliquefaciens improves cytidine production in Escherichia coli
Cytidine is an important raw material for nucleic acid health food and genetic engineering research. In recent years, it has shown irreplaceable effects in anti-virus, anti-tumor, and AIDS drugs. Its biosynthe...
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Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants
A Correction to this paper has been published: https://doi.org/10.1038/s41422-021-00475-z
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The oncogenomic function of androgen receptor in esophageal squamous cell carcinoma is directed by GATA3
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Open AccessNovel mechanisms underlying anti-polycystic ovary like syndrome effects of electroacupuncture in rats: suppressing SREBP1 to mitigate insulin resistance, mitochondrial dysfunction and oxidative stress
Acupuncture, a therapy of traditional Chinese medicine, is confirmed to exert the therapeutic action on polycystic ovary syndrome (PCOS). However, the detailed therapeutic mechanisms of acupuncture in PCOS rem...
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Comparing the Effects of Biochar and Straw Amendment on Soil Carbon Pools and Bacterial Community Structure in Degraded Soil
The degradation of soil often occurs due to the depletion of organic matter. Both biochar and straw have value as two primary means of remediating soil. In this study, we compar...
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Open AccessEffects of cryopreservation and long-term culture on biological characteristics and proteomic profiles of human umbilical cord-derived mesenchymal stem cells
Human umbilical cord-derived MSCs (hUC-MSCs) have been identified as promising seeding cells in tissue engineering and clinical applications of regenerative medicine due to their advantages of simple acquisiti...
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Phytochemical and Gene Expression Reveals the Antioxidant Responses to Copper Ions in Brassica rapa
The toxicity of increasing heavy metal ion in soil has been threatening the food security and environments. In this study, we used Brassica rapa variety Qinggen #1, a leafy and oil vegetable, to investigate the e...
