43 Result(s)

Article

Colorectal cancer cells secreting DKK4 transform fibroblasts to promote tumour metastasis

Wnt/β-catenin signalling is aberrantly activated in most colorectal cancer (CRC) and is one key driver involved in the initiation and progression of CRC. However, mutations of APC gene in CRC patients retain c...

Xue Li, Yulin Chen, Ran Lu, Min Hu, Lei Gu, Qiaorong Huang, Wentong Meng… in Oncogene (2024)

Article

A novel long non-coding RNA SLNCR1 promotes proliferation, migration, and invasion of melanoma via transcriptionally regulating SOX5

Steroid receptor RNA activator (SRA)-like non-coding RNA (SLNCR1) has been implicated in various tumorigenic processes, but the precise regulatory role in melanoma progression remains uncertain. We performed a...

Lele Cong, Qing Zhao, Hongyan Sun, Zilong Zhou, Yue Hu, Chunyi Li… in Cell Death Discovery (2024)

Article

TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target

Copy number alterations are crucial for the development of gastric cancer (GC). Here, we identified Transmembrane Protein 65 (TMEM65) amplification by genomic hybridization microarray to profile copy-number va...

Lingxue Shi, **aohong Wang, Shang Guo, Hongyan Gou, Haiyun Shang, **aojia Jiang… in Oncogene (2024)

Article

DUSP4 modulates RIG-I- and STING-mediated IRF3-type I IFN response

Detection of cytosolic nucleic acids by pattern recognition receptors, including STING and RIG-I, leads to the activation of multiple signalling pathways that culminate in the production of type I interferons ...

Huipeng Jiao, Sharmy J. James, Chin Wen Png, Chaoyu Cui… in Cell Death & Differentiation (2024)

Article

Caspase cleavage of RIPK3 after Asp³³³ is dispensable for mouse embryogenesis

The proteolytic activity of caspase-8 suppresses lethal RIPK1-, RIPK3- and MLKL-dependent necroptosis during mouse embryogenesis. Caspase-8 is reported to cleave RIPK3 in addition to the RIPK3-interacting kina...

Kim Newton, Katherine E. Wickliffe, Allie Maltzman… in Cell Death & Differentiation (2024)

Article

Regulated secretion of mutant p53 negatively affects T lymphocytes in the tumor microenvironment

Several studies have demonstrated the role of the oncogenic mutant p53 in promoting tumor progression; however, there is limited information on the effects of secreted oncogenic mutant p53 on the tumor microen...

**ang Dong, Chunlu Li, Chengsi Deng, **gwei Liu, Danni Li, Tingting Zhou… in Oncogene (2024)

Article

Deep learning identifies a T-cell exhaustion-dependent transcriptional signature for predicting clinical outcomes and response to immune checkpoint blockade

Immune checkpoint blockade (ICB) therapies have brought unprecedented advances in cancer treatment, but responses are limited to a fraction of patients. Therefore, sustained and substantial efforts are require...

Zicheng Zhang, Hongyan Chen, Dongxue Yan, Lu Chen, Jie Sun, Meng Zhou in Oncogenesis (2023)

Article

Correction: Radiation-induced gastrointestinal (GI) syndrome as a function of age

Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao… in Cell Death Discovery (2023)

Article

The sodium channel subunit SCNN1B suppresses colorectal cancer via suppression of active c-Raf and MAPK signaling cascade

The incidence of colorectal cancer (CRC) is rising worldwide. Here, we identified SCNN1B as an outlier down-regulated in CRC and it functions as a tumor suppressor. SCNN1B mRNA and protein expression were down...

Yun Qian, Lianxin Zhou, Simson Tsz Yat Luk, Jiaying Xu, Weilin Li, Hongyan Gou… in Oncogene (2023)

Article

Radiation-induced gastrointestinal (GI) syndrome as a function of age

Previous studies show increased sensitivity of older mice (28–29 months) compared with young adult mice (3 months, possessing a mature immune system) to radiation-induced GI lethality. Age-dependent lethality ...

Hongyan Li, Herman C. Kucharavy, Carla Hajj, Liyang Zhao… in Cell Death Discovery (2023)

Article

DUSP5P1 promotes gastric cancer metastasis and platinum drug resistance

We elucidated the functional significance and molecular mechanisms of DUSP5P1 lncRNA (dual specificity phosphatase 5 pseudogene 1) in gastric carcinogenesis. We demonstrated that gastric cancer (GC) patients w...

**aohong Wang, Lianhai Zhang, Qiaoyi Liang, Chi Chun Wong, Huarong Chen… in Oncogenesis (2022)

Article

Roles of lncRNA LVBU in regulating urea cycle/polyamine synthesis axis to promote colorectal carcinoma progression

Altered expression of Urea Cycle (UC) enzymes occurs in many tumors, resulting a metabolic hallmark termed as UC dysregulation. Polyamines are synthesized from ornithine, and polyamine synthetic genes are elev...

**angqi Meng, **gxuan Peng, **aoshan **e, Fenghai Yu, Wencong Wang, Qihao Pan… in Oncogene (2022)

Article

Osteopontin aggravates acute lung injury in influenza virus infection by promoting macrophages necroptosis

Infection with influenza A virus (IAV) can trigger pulmonary inflammation and lung damage. Osteopontin (OPN) is an essential regulator of cell death and immunity. However, the role and underlying mechanism of ...

**** Wang, Xuehui Li, Yuchong Wang, Yuyu Li, Fan Shi… in Cell Death Discovery (2022)

Article

Senescence as a dictator of patient outcomes and therapeutic efficacies in human gastric cancer

Senescence is believed to be a pivotal player in the onset and progression of tumors as well as cancer therapy. However, the guiding roles of senescence in clinical outcomes and therapy selection for patients ...

Lulin Zhou, Zubiao Niu, Yuqi Wang, You Zheng, Yichao Zhu… in Cell Death Discovery (2022)