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Open AccessHematopoietic stem and progenitor cell membrane-coated vesicles for bone marrow-targeted leukaemia drug delivery
Leukemia is a kind of hematological malignancy originating from bone marrow, which provides essential signals for initiation, progression, and recurrence of leukemia. However, how to specifically deliver drugs...
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Article
Open AccessElastic strain-induced amorphization in high-entropy alloys
Elastic stability is the basis for understanding structural responses to external stimuli in crystalline solids, including melting, incipient plasticity and fracture. In this work, elastic stability is investi...
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Article
Open AccessPeptide nano-blanket impedes fibroblasts activation and subsequent formation of pre-metastatic niche
There is evidence to suggest that the primary tumor induces the formation of a pre-metastatic niche in distal organs by stimulating the production of pro-metastatic factors. Given the fundamental role of the p...
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Article
Open AccessDivergent Effects of Nitrogen Addition on Soil Respiration in a Semiarid Grassland
Nitrogen (N) deposition has been steadily increasing for decades, with consequences for soil respiration. However, we have a limited understanding of how soil respiration responds to N availability. Here, we i...
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Article
Open AccessLong term prevention of disturbance induces the collapse of a dominant species without altering ecosystem function
Limitation of disturbances, such as grazing and fire, is a key tool for nature reserve management and ecological restoration. While the role of these disturbances in sha** ecosystem structure and functioning...
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Article
Aridity threshold in controlling ecosystem nitrogen cycling in arid and semi-arid grasslands
Higher aridity and more extreme rainfall events in drylands are predicted due to climate change. Yet, it is unclear how changing precipitation regimes may affect nitrogen (N) cycling, especially in areas with ...
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Article
Grazing-induced reduction of natural nitrous oxide release from continental steppe
Levels of the greenhouse gas nitrous oxide have increased since pre-industrial times, mainly because of agricultural activities. Among these changes it has been reported that livestock grazing substantially in...