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Interleukin-36 is overexpressed in human sepsis and IL-36 receptor deletion aggravates lung injury and mortality through epithelial cells and fibroblasts in experimental murine sepsis

Sepsis is defined as a life-threatening syndrome caused by an unbalanced host response to infection. The role of interleukin (IL)-36 cytokines binding to the IL-36 receptor (IL-36R) in host response during sep...

Huachen Wang, Meixiang Wang, Junlan Chen, Hongda Hou, Zheng Guo, Hong Yang… in Critical Care (2023)