-
Article
Multimodal variational contrastive learning for few-shot classification
The effectiveness of metric-based few-shot learning methods heavily relies on the discriminative ability of the prototypes and feature embeddings of queries. However, using instance-level unimodal prototypes o...
-
Article
Interleukin-17A mediates tobacco smoke–induced lung cancer epithelial-mesenchymal transition through transcriptional regulation of ΔNp63α on miR-19
Interleukin-17A (IL-17A) is an essential inflammatory cytokine in the progress of carcinogenesis. Tobacco smoke (TS) is a major risk factor of lung cancer that influences epithelial-mesenchymal transition (EMT...
-
Article
Open AccessSNP rs17079281 decreases lung cancer risk through creating an YY1-binding site to suppress DCBLD1 expression
Genome-wide association studies (GWAS) have identified numerous genetic variants that are associated with lung cancer risk, but the biological mechanisms underlying these associations remain largely unknown. H...
-
Article
Open AccessThe inherited variations of a p53-responsive enhancer in 13q12.12 confer lung cancer risk by attenuating TNFRSF19 expression
Inherited factors contribute to lung cancer risk, but the mechanism is not well understood. Defining the biological consequence of GWAS hits in cancers is a promising strategy to elucidate the inherited mechan...
-
Article
Dynamic regulation of CD28 conformation and signaling by charged lipids and ions
CD28 signaling motifs are sequestered within the membrane via interactions with phospholipids. TCR activation increases the local Ca2+ concentration, which disrupts CD28-lipid interactions.
-
Article
Eye-safe Raman laser based on BaTeMo2O9 crystal
An eye-safe Raman laser is realized with BaTeMo2O9 (BTM) nonlinear crystal for the first time. By using a diode-end-pumped acousto-optically Q-switched Nd:YVO4 laser as the pum** source, the BTM crystal convert...
-
Article
Graphene-based passively Q-switched Nd:KLu(WO4)2 eye-safe laser operating at 1,425 nm
With graphene as saturable absorber, an Nd:KLu(WO4)2 eye-safe laser operating at 1,425 nm is demonstrated. To the best of our knowledge, this is the first demonstration that an Nd:KLu(WO4)2 laser operates at the...
-
Article
1.8 μm optical parametric oscillator based on KTiOPO4
A 1.8 μm optical parametric oscillator pumped by a diode end-pumped acousto-optically Q-switched Nd:YAG is demonstrated. A 30-mm-long KTiOPO4 crystal cut with an angle of θ = 59.4°, φ = 0° is employed as the OPO ...
-
Article
STK31(TDRD8) is dynamically regulated throughout mouse spermatogenesis and interacts with MIWI protein
Tudor-domain-containing proteins (TDRDs) are suggested to be critical regulators of germinal granules assembly involved in Piwi-interacting RNAs (piRNAs)-mediated pathways, of which associated components and t...
-
Article
Propagating property of flat-topped multi-Gaussian beams passing through a misaligned optical system with two-lens and two-diaphragm
The optical elements’ maladjustment is a potential threaten in optical systems, thus, the transmission feature of laser beams passing through a misaligned optical system is widely studied. By using approximate...
-
Article
FAS and FAS Ligand Polymorphisms in the Promoter Regions and Risk of Gastric Cancer in Southern China
The FAS and FAS ligand (FASLG) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis. Functional promoter polymorphism...
-
Article
PCA for predicting quaternary structure of protein
The number and arrangement of subunits that form a protein are referred to as quaternary structure. Knowing the quaternary structure of an uncharacterized protein provides clues to finding its biological funct...
-
Article
Attribute weighted mercer kernel based fuzzy clustering algorithm for general non-spherical datasets
Clustering analysis is an important topic in artificial intelligence, data mining and pattern recognition research. Conventional clustering algorithms, for instance, the famous Fuzzy C-means clustering algorit...
-
Chapter and Conference Paper
A New Scaling Kernel-Based Fuzzy System with Low Computational Complexity
The approximation capability of fuzzy systems heavily depends on the shapes of the chosen fuzzy membership functions. When fuzzy systems are applied in adaptive control, computational complexity and generaliza...
