17 Result(s)

Article

LATS2 degradation promoted fibrosis damage and rescued by vitamin K3 in lupus nephritis

Lupus nephritis (LN) is the most common complication of systemic lupus erythematosus (SLE). The limited treatment options for LN increase the economic burdens on patients. Because fibrotic progression leads to...

Chen Cheng, Hao Yang, Chan Yang, Juan **e, **shen Wang… in Arthritis Research & Therapy (2024)

Article

Identification and characterization of a new geminivirus from soybean plants and determination of V2 as a pathogenicity factor and silencing suppressor

Soybean is one of the four major crops in China. The occurrence of viruses in soybean causes significant economic losses.

Qinglun Li, Yuyang Zhang, Weiguo Lu, **aoyu Han, Lingling Yang… in BMC Plant Biology (2022)

Article

A rapid, simple, and highly efficient method for VIGS and in vitro-inoculation of plant virus by INABS applied to crops that develop axillary buds and can survive from cuttings

Virus-induced gene silencing (VIGS) is one of the most convenient and powerful methods of reverse genetics. In vitro-inoculation of plant virus is an important method for studying the interactions between viru...

Qili Liu, Kedong Xu, Lun Yi, Yalin Hou, Dongxiao Li, Haiyan Hu… in BMC Plant Biology (2021)

Article

A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies

Intraneuronal accumulation of hyperphosphorylated tau is a hallmark pathology shown in over twenty neurodegenerative disorders, collectively termed as tauopathies, including the most common Alzheimer’s disease...

Jie Zheng, Na Tian, Fei Liu, Yidian Zhang… in Signal Transduction and Targeted Therapy (2021)

Article

Heparanase overexpression impedes perivascular clearance of amyloid-β from murine brain: relevance to Alzheimer’s disease

Defective amyloid-β (Aβ) clearance from the brain is a major contributing factor to the pathophysiology of Alzheimer’s disease (AD). Aβ clearance is mediated by macrophages, enzymatic degradation, perivascular...

**ao Zhang, Paul O’Callaghan, Honglian Li… in Acta Neuropathologica Communications (2021)

Article

Identification and functional analyses of host factors interacting with the 17-kDa protein of Barley yellow dwarf virus-GAV

Barley yellow dwarf viruses (BYDVs) cause significant economic losses on barley, wheat, and oats worldwide. 17-kDa protein (17K) of BYDVs plays a key role in viral infection in plants, whereas the underlying r...

Siyu Chen, **aoyu Han, Lingling Yang, Qinglun Li, Yajuan Shi… in Scientific Reports (2021)

Article

FpCzf14 is a putative C₂H₂ transcription factor regulating conidiation in Fusarium pseudograminearum

C₂H₂ zinc finger transcription factors such as FlbC and Msn2, have broad regulatory roles in fungal growth and conidiation. In the present study, we cloned and characterized a C₂H₂ zinc finger transcription facto...

Linlin Chen, **gya Zhao, Huiqing **a, Yuming Ma, Yankun Liu… in Phytopathology Research (2020)

Article

First report of sweet potato feathery mottle virus infecting Amaranthus blitum in China

Fumei Zhao, Zhenchen Zhang, Honglian Li, Qi Qiao, Shuang Wang… in Journal of Plant Pathology (2020)

Article

The bZIP transcription factor FpAda1 is essential for fungal growth and conidiation in Fusarium pseudograminearum

Fusarium pseudograminearum is an important pathogen of Fusarium crown rot and Fusarium head blight, which is able to infect wheat and barley worldwide, causing great economic losses. Transcription factors (TFs) o...

Linlin Chen, Yuming Ma, **gya Zhao, Xue**g Geng, Wenbo Chen… in Current Genetics (2020)

Article

Posterior basolateral amygdala to ventral hippocampal CA1 drives approach behaviour to exert an anxiolytic effect

The basolateral amygdala (BLA) and ventral hippocampal CA1 (vCA1) are cellularly and functionally diverse along their anterior–posterior and superficial-deep axes. Here, we find that anterior BLA (aBLA) and po...

Guilin Pi, Di Gao, Dongqin Wu, Yali Wang, Huiyang Lei, Wenbo Zeng… in Nature Communications (2020)

Article

Identification of cucurbit chlorotic yellows virus P4.9 as a possible movement protein

Cucurbit chlorotic yellows virus (CCYV) is a bipartite cucurbit-infecting crinivirus within the family Closteroviridae. The crinivirus genome varies among genera. P4.9 is the first protein encoded by CCYV RNA2. P...

Ying Wei, Yajuan Shi, Xaioyu Han, Siyu Chen, Honglian Li, Linlin Chen… in Virology Journal (2019)

Article

SET SUMOylation promotes its cytoplasmic retention and induces tau pathology and cognitive impairments

PP2A is a major regulator of tau phosphorylation, which is principally regulated by an endogenous nuclear protein inhibitor 2 of PP2A (I₂^PP2A), also named SET. However, how SET is post-translationally regulated a...

Min Qin, Honglian Li, Jian Bao, Yiyuan **a, Dan Ke… in Acta Neuropathologica Communications (2019)

Article

Development of a GFP expression vector for Cucurbit chlorotic yellows virus

Cucurbit chlorotic yellows virus (CCYV), a bipartite crinivirus, causes chlorotic leaf spots and yellowing symptoms on cucurbit leaves. We previously developed an infectious clone of CCYV. Limited work has been c...

Ying Wei, **aoyu Han, Zhenyue Wang, Qinsheng Gu, Honglian Li… in Virology Journal (2018)

Article

Transgenic Nicotiana benthamiana plants expressing a hairpin RNAi construct of a nematode Rs-cps gene exhibit enhanced resistance to Radopholus similis

Burrowing nematodes (Radopholus similis) cause severe harm in many agronomic and horticultural crops and are very difficult to manage. Cathepsin S is one of the most important cysteine proteinases and plays key r...

Yu Li, Ke Wang, Qisen Lu, Juan Du, Zhenyue Wang, Desen Wang… in Scientific Reports (2017)

Article

Network and role analysis of autophagy in Phytophthora sojae

Autophagy is an evolutionarily conserved mechanism in eukaryotes with roles in development and the virulence of plant fungal pathogens. However, few reports on autophagy in oomycete species have been published...

Linlin Chen, **ong Zhang, Wen Wang, Xue**g Geng, Yan Shi, Risong Na… in Scientific Reports (2017)

Article

Transcriptome analysis of Cucumis sativus infected by Cucurbit chlorotic yellows virus

Cucurbit chlorotic yellows virus (CCYV) is a recently reported bipartite crinivirus that causes chlorotic leaf spots and yellowing symptoms on the leaves of cucurbit plants. The virus–...

**nyan Sun, Zhenyue Wang, Qinsheng Gu, Honglian Li, Weili Han, Yan Shi in Virology Journal (2017)

Article

Magnetoresistance of the ferromagnetic nanocontacts fabricated by electrodeposition

A “T” shaped micro-gap was fabricated by mechanical polishing between two Cu film electrodes on the surface of single-sided bonded copper. A nano-gap was then fabricated in the prepared micro-gap by resistance...

Hao Cheng, Wei Yang, Hong Liu, HongLian Li, LingJiang Wang in Chinese Science Bulletin (2013)