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Article
Themis suppresses the effector function of CD8+ T cells in acute viral infection
CD8+ T cells play a central role in antiviral immune responses. Upon infection, naive CD8+ T cells differentiate into effector cells to eliminate virus-infected cells, and some of these effector cells further dif...
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Article
Open AccessTMEM25 inhibits monomeric EGFR-mediated STAT3 activation in basal state to suppress triple-negative breast cancer progression
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with poor outcome and lacks of approved targeted therapy. Overexpression of epidermal growth factor receptor (EGFR) is found in more than 50% ...
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Article
Open AccessA theoretical study of the effect and mechanism of FeN3-doped biochar for greenhouse gas mitigation
Paddy fields are a major emission source of greenhouse gases (GHGs) [for instance, methane (CH4), nitrous oxide (N2O), and carbon dioxide (CO2)] among agricultural fields. Biochar has been deemed a potential cand...
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Article
Bifunctional sulfonated covalent polymers as the modulator for oriented and highly reversible zinc plating
The vast superiority in resource sustainability and volumetric energy density enables metallic zinc (Zn) to construct cost-effective and environment-benign battery systems for the energy storage. However, the ...
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Article
Open AccessTargeting EGFR-dependent tumors by disrupting an ARF6-mediated sorting system
Aberrant activation of EGFR due to overexpression or mutation is associated with poor prognosis in many types of tumors. Here we show that blocking the sorting system that directs EGFR to plasma membrane is a ...
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Chapter and Conference Paper
Multi-loop Adaptive Differential Evolution for Large-Scale Expensive Optimization
Data-driven evolutionary algorithms (DDEAs) have shown promising performance in solving small- and medium-scale expensive optimization problems (EOPs) with low and medium dimensions. However, the performance o...
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Article
Open AccessCD36 facilitates fatty acid uptake by dynamic palmitoylation-regulated endocytosis
Fatty acids (FAs) are essential nutrients, but how they are transported into cells remains unclear. Here, we show that FAs trigger caveolae-dependent CD36 internalization, which in turn delivers FAs into adipo...
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Article
Improved Corrosion Resistance of Selective Laser Melted Ti–5Cu Alloy Using Atomized Ti–5Cu Powder
The different types of metal powder used for selective laser melting (SLM) process would cause distinct corrosion behavior due to the uniformity of the obtained microstructure. The SLM-produced Ti–5Cu alloy us...
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Article
Stability Analysis and Dynamic Output Feedback Control for Nonlinear T-S Fuzzy System with Multiple Subsystems and Normalized Membership Functions
This paper addresses the stability analysis and dynamic output-feedback control problems for a class of nonlinear Takagi-Sugeno (T-S) fuzzy systems with multiple subsystems and normalized membership functions....
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Article
Open AccessATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage
DNA damage can induce autophagy; however, the underlying mechanism remains largely unknown. Here we report that DNA damage leads to autophagy through ATR/Chk1/RhoB-mediated lysosomal recruitment of TSC complex...
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Article
Adaptive Dynamic Output-feedback Control for Chemical Continuous Stirred Tank Reactor System with Nonlinear Uncertainties and Multiple Time-delays
This paper addresses the dynamic-output-feedback control problem for a class of nonlinear system with nonlinear uncertainties and multiple time-delays. Compared with the previous work, the time delay parameter...
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Article
High electro-catalytic graphite felt/MnO2 composite electrodes for vanadium redox flow batteries
A mild and simple synthesis process for large-scale vanadium redox flow batteries (VRFBs) energy storage systems is desirable. A graphite felt/MnO2 (GF-MNO) composite electrode with excellent electrocatalytic act...
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Article
Quantile regression based on counting process approach under semi-competing risks data
In this paper, we investigate the quantile regression analysis for semi-competing risks data in which a non-terminal event may be dependently censored by a terminal event. The estimation of quantile regression...
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Article
Waterlogging risk assessment based on self-organizing map (SOM) artificial neural networks: a case study of an urban storm in Bei**g
Due to rapid urbanization, waterlogging induced by torrential rainfall has become a global concern and a potential risk affecting urban habitant’s safety. Widespread waterlogging disasters have occurred almost...
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Article
Synthesis and characterization of carborane bisphenol resol phenolic resins with ultrahigh char yield
Two carborane-containing resol phenolic resins (P1 and P2) with high boron content were synthesized via the reaction of carborane bisphenols (1 and 2) with formaldehyde in the presence of alkaline. HRMS results i...
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Article
Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity
Mitochondria must be juxtaposed to phagosomes to supply reactive oxygen species for effective killing of microbes. Zhou and colleagues demonstrate that the kinases Mst1 and Mst2 are important for controlling t...
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Article
Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis
The role of the unfolded protein response (UPR) in tissue homeostasis remains largely unknown. Here we find that loss of Mst1/2, the mammalian Hippo orthologues, or their regulator WW45, leads to a remarkably ...
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Article
ATR/Chk1/Smurf1 pathway determines cell fate after DNA damage by controlling RhoB abundance
ATM- and RAD3-related (ATR)/Chk1 and ataxia–telangiectasia mutated (ATM)/Chk2 signalling pathways play critical roles in the DNA damage response. Here we report that the E3 ubiquitin ligase Smurf1 determines c...
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Article
The covalent modifier Nedd8 is critical for the activation of Smurf1 ubiquitin ligase in tumorigenesis
Neddylation, the covalent attachment of ubiquitin-like protein Nedd8, of the Cullin-RING E3 ligase family regulates their ubiquitylation activity. However, regulation of HECT ligases by neddylation has not bee...
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Article
Difference systems of sets based on cosets partitions
Difference systems of sets (DSS) are combinatorial configurations that arise in connection with code synchronization. This paper proposes a new method to construct DSSs, which uses known DSSs to partition some...
