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Article
Open AccessGut microbiota helps identify clinical subtypes of Parkinson’s disease
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Article
Mathematical Analysis on a General Delayed HBV Model with Capsids and Two Infection Routes
Considering that HBV belongs to the DNA virus family and is hepatotropic, we model the HBV DNA-containing capsids as a compartment. In this paper, a delayed HBV infection model is established, where the genera...
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Article
Open AccessIdentification of membrane curvature sensing motifs essential for VPS37A phagophore recruitment and autophagosome closure
VPS37A, an ESCRT-I complex component, is required for recruiting a subset of ESCRT proteins to the phagophore for autophagosome closure. However, the mechanism by which VPS37A is targeted to the phagophore rem...
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Article
Open AccessMultifaceted membrane interactions of human Atg3 promote LC3-phosphatidylethanolamine conjugation during autophagy
Autophagosome formation, a crucial step in macroautophagy (autophagy), requires the covalent conjugation of LC3 proteins to the amino headgroup of phosphatidylethanolamine (PE) lipids. Atg3, an E2-like enzyme,...
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Article
Role of TPEN in Amyloid-β25–35-Induced Neuronal Damage Correlating with Recovery of Intracellular Zn2+ and Intracellular Ca2+ Overloading
The overproduction of neurotoxic amyloid-β (Aβ) peptides in the brain is a hallmark of Alzheimer’s disease (AD). To determine the role of intracellular zinc ion (iZn2+) dysregulation in mediating Aβ-related neuro...
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Article
IGF2BP1 regulates the cargo of extracellular vesicles and promotes neuroblastoma metastasis
Neuroblastoma is a highly metastatic cancer, and thus is one of the leading causes of cancer-related mortalities in pediatric patients. More than 50% of NB cases exhibit 17q21-ter partial chromosomal gain, whi...
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Article
Open AccessThe human ion channel TRPM2 modulates migration and invasion in neuroblastoma through regulation of integrin expression
Transient receptor potential channel TRPM2 is highly expressed in many cancers and involved in regulation of key physiological processes including mitochondrial function, bioenergetics, and oxidative stress. I...
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Article
Open AccessJatrorrhizine alleviates ulcerative colitis via regulating gut microbiota and NOS2 expression
The natural protoberberine jatrorrhizine (JA) is reported to have several medicinal properties and a significant effect on the gut microbiota of mice. The regulation of gut microbiota is generally known to pla...
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Article
A real-time high dynamic range intensified complementary metal oxide semiconductor camera based on FPGA
To capture more details and enhance image’s contrast in a low-light-level (LLL) environment and improve the performance of the LLL night vision system, a method of extending the dynamic range for the LLL night...
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Article
Open AccessThe human ion channel TRPM2 modulates cell survival in neuroblastoma through E2F1 and FOXM1
Transient receptor potential channel melastatin 2 (TRPM2) is highly expressed in cancer and has an essential function in preserving viability through maintenance of mitochondrial function and antioxidant respo...
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Article
LncRNA XIST facilitates S1P-mediated osteoclast differentiation via interacting with FUS
The diagnosis and treatment of osteoporosis, a frequent age-related metabolic bone disorder, remain incomprehensive and challenging. The potential regulatory role of lncRNA XIST and sphingosine kinase 1 (SPHK1...
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Article
NMR resonance assignments of human Atg3 in aqueous solution and bicelles
Human Atg3 (hAtg3) is an E2-like enzyme that catalyzes the conjugation of LC3 family proteins to phosphatidylethanolamine (PE) lipids in the autophagosomal membrane during autophagy. The reaction product, LC3-...
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Article
Open AccessPIGN spatiotemporally regulates the spindle assembly checkpoint proteins in leukemia transformation and progression
Phosphatidylinositol glycan anchor biosynthesis class N (PIGN) has been linked to the suppression of chromosomal instability. The spindle assembly checkpoint complex is responsible for proper chromosome segreg...
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Article
Open AccessTPEN attenuates amyloid-β25–35-induced neuronal damage with changes in the electrophysiological properties of voltage-gated sodium and potassium channels
To understand the role of intracellular zinc ion (Zn2+) dysregulation in mediating age-related neurodegenerative changes, particularly neurotoxicity resulting from the generation of excessive neurotoxic amyloid-β...
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Article
Targeting the ESCRT-III component CHMP2A for noncanonical Caspase-8 activation on autophagosomal membranes
Autophagosomal membranes can serve as activation platforms for intracellular death-inducing signaling complexes (iDISCs) to initiate Caspase-8-dependent apoptosis. In this study, we explore the impact of ESCRT...
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Article
Open AccessAn N-terminal conserved region in human Atg3 couples membrane curvature sensitivity to conjugase activity during autophagy
During autophagy the enzyme Atg3 catalyzes the covalent conjugation of LC3 to the amino group of phosphatidylethanolamine (PE) lipids, which is one of the key steps in autophagosome formation. Here, we have de...
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Chapter and Conference Paper
Design of Personal Learning Model Recognition Model for Online Teaching of Ideological and Political Theory Course
Accurate identification of students’ learning modes in online teaching of ideological and political theory courses is helpful to improve students’ concentration in the learning process and enhance the effect o...
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Chapter and Conference Paper
Multi Mode Interactive Information Processing Method in Online Education System of Ideological and Political Course
In order to optimize the traditional online teaching mode, taking the basic course of Ideological and political online teaching design as an example, this paper proposes a multi-mode interactive information pr...
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Article
Open AccessIdentification of regulators of poly-ADP-ribose polymerase inhibitor response through complementary CRISPR knockout and activation screens
Inhibitors of poly-ADP-ribose polymerase 1 (PARPi) are highly effective in killing cells deficient in homologous recombination (HR); thus, PARPi have been clinically utilized to successfully treat BRCA2-mutant...
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Article
Open AccessTherapeutic targeting of FLT3 and associated drug resistance in acute myeloid leukemia
Acute myeloid leukemia (AML) is a heterogeneous disease caused by several gene mutations and cytogenetic abnormalities affecting differentiation and proliferation of myeloid lineage cells. FLT3 is a receptor t...
