50 Result(s)
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Article
Dynamic intrauterine crosstalk promotes porcine embryo implantation during early pregnancy
Dynamic crosstalk between the embryo and mother is crucial during implantation. Here, we comprehensively profile the single-cell transcriptome of pig peri-implantation embryos and corresponding maternal endome...
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Article
Potentiation of the lateral habenula-ventral tegmental area pathway underlines the susceptibility to depression in mice with chronic pain
Chronic pain often develops severe mood changes such as depression. However, how chronic pain leads to depression remains elusive and the mechanisms determining individuals’ responses to depression are largely...
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Article
CDK13 promotes lipid deposition and prostate cancer progression by stimulating NSUN5-mediated m5C modification of ACC1 mRNA
Cyclin-dependent kinases (CDKs) regulate cell cycle progression and the transcription of a number of genes, including lipid metabolism-related genes, and aberrant lipid metabolism is involved in prostate carci...
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Article
Open AccessWeighted gene co-expression network analysis identified hub genes critical to fatty acid composition in Gushi chicken breast muscle
The composition and content of fatty acids in the breast muscle are important factors influencing meat quality. In this study, we investigated the fatty acid composition and content in the breast muscle of Gus...
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Widespread 8-oxoguanine modifications of miRNA seeds differentially regulate redox-dependent cancer development
Oxidative stress contributes to tumourigenesis by altering gene expression. One accompanying modification, 8-oxoguanine (o8G) can change RNA–RNA interactions via o8G•A base pairing, but its regulatory roles remai...
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Open AccessGenetic architecture and key regulatory genes of fatty acid composition in Gushi chicken breast muscle determined by GWAS and WGCNA
Fatty acids composition in poultry muscle is directly related to its tenderness, flavour, and juiciness, whereas its genetic mechanisms have not been elucidated. In this study, the genetic structure and key re...
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Article
Network prediction of surgical complication clusters: a prospective multicenter cohort study
Complicated relationships exist in both occurrence and progression of surgical complications, which are difficult to account for using a separate quantitative method such as prediction or grading. Data of 51,0...
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NCOR1 maintains the homeostasis of vascular smooth muscle cells and protects against aortic aneurysm
Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays critical roles in the pathogenesis of aortic aneurysm (AA). The function of nuclear receptor corepressor1 (NCOR1) in regulation of VSMC pheno...
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Article
Changes in phenylalanine and glucosinolate concentrations in the leaves of kimchi cabbage colonized by Heteroconium chaetospira
Kimchi cabbage is the main ingredient in kimchi, and improvements in yield and quality are therefore meaningful for the health of the consumer and the kimchi industry. In light of this, the present study inves...
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Article
Genome-wide signatures of the geographic expansion and breeding of soybean
Soybean is a leguminous crop that provides oil and protein. Exploring the genomic signatures of soybean evolution is crucial for breeding varieties with improved adaptability to environmental extremes. We anal...
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Article
Open AccessSF3B4 promotes Twist1 expression and clear cell renal cell carcinoma progression by facilitating the export of KLF 16 mRNA from the nucleus to the cytoplasm
Splicing factor 3B subunit 4 (SF3B4) plays important functional roles not only in pre-mRNA splicing, but also in the regulation of transcription, translation, and cell signaling, and its dysregulation contribu...
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Article
Open AccessA composite strategy of genome-wide association study and copy number variation analysis for carcass traits in a Duroc pig population
Carcass traits are important in pig breeding programs for improving pork production. Understanding the genetic variants underlies complex phenotypes can help explain trait variation in pigs. In this study, we ...
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Discovery of small-molecule activators of nicotinamide phosphoribosyltransferase (NAMPT) and their preclinical neuroprotective activity
The decline of nicotinamide adenine dinucleotide (NAD) occurs in a variety of human pathologies including neurodegeneration. NAD-boosting agents can provide neuroprotective benefits. Here, we report the discov...
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Open AccessInhibition of RIPK1 by ZJU-37 promotes oligodendrocyte progenitor proliferation and remyelination via NF-κB pathway
Receptor interacting serine/threonine protein kinase 1 (RIPK1) activation and necroptosis have been genetically and mechanistically linked with human multiple sclerosis and neurodegenerative diseases for which...
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Open AccessmiR-204-5p is sponged by TUG1 to aggravate neuron damage induced by focal cerebral ischemia and reperfusion injury through upregulating COX2
Studies have reported that miR-204-5p is involved in multiple biological processes. However, little is known about the expression and mechanism of miR-204-5p in cerebral ischemia and reperfusion injury. This s...
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Open AccessImpairment of μ-calpain activation by rhTNFR:Fc reduces severe burn-induced membrane disruption in the heart
Stress cardiomyopathy is a major clinical complication after severe burn. Multiple upstream initiators have been identified; however, the downstream targets are not fully understood. This study assessed the ro...
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Open AccessCirc_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation
With an increasing aging society, China is the world’s fastest growing markets for oral implants. Compared with traditional oral implants, immediate implants cause marginal bone resorption and increase the fai...
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Open AccessBSR-Seq analysis provides insights into the cold stress response of Actinidia arguta F1 populations
Freezing injury, which is an important abiotic stress in horticultural crops, influences the growth and development and the production area of kiwifruit (Actinidia Lind1). Among Actinidia species, Actinidia argut...
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Open AccessABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway
The development of resistance to anticancer drugs is believed to cause chemotherapy failure in pancreatic cancer (PC). The efflux of anticancer drugs mediated by ATP-binding cassette (ABC) transporters is a wi...
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Open AccessCG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila
