72 Result(s)
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Article
Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview
Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic ...
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Article
Open AccessInterleaved step-down converter with capacitor-diode voltage splitter and minimum switches for low current ripple and extra-low voltage ratio
This paper proposes an interleaved step-down converter (ISDC) with a capacitor-diode voltage splitter. Even though the ISDC only utilizes two active switches, it can significantly step down a high input voltag...
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Article
Lactonization of dyes promoted by a coordination cage facilitates cavity-induced chromism as ion mobile detector
Dye molecules often change colors (so-called “chromism”) according to the environment variation. However, they are rarely induced by a catalytic amount of cavity. Through encapsulation in the cavity of a porou...
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Article
Author Correction: Engineering a precise adenine base editor with minimal bystander editing
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Article
Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression
Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cell...
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Article
A general copper-catalysed enantioconvergent C(sp3)–S cross-coupling via biomimetic radical homolytic substitution
Although α-chiral C(sp3)–S bonds are of enormous importance in organic synthesis and related areas, the transition-metal-catalysed enantioselective C(sp3)–S bond construction still represents an underdeveloped do...
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Article
Cu-catalysed enantioselective radical heteroatomic S–O cross-coupling
The transition-metal-catalysed cross-coupling reaction has established itself as one of the most reliable and practical synthetic tools for the efficient construction of carbon–carbon/heteroatom (p-block elements...
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Oligonucleotide Containing 8-Trifluoromethyl-2′-Deoxyguanosine as a Z-DNA Probe
Z-DNA structure is a noncanonical left-handed alternative form of DNA, which has been suggested to be biologically important and is related to several genetic diseases and cancer. Therefore, investigation of Z...
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Article
Two New Prenylated Flavonoids from the Leaves of Macaranga pustulata
Two new flavonoids, 8,2′-diprenyl-3,5,7,5′-tetrahydroxyflavone (1) and 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin (2), along with twelve known compounds (3–14), were isolated from the leaves of Macaranga...
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Article
A computational study to reveal selpercatinib resistance to RET kinase double mutant V804M/Y806C
As a member of the receptor tyrosine kinase family, rearranged during transfection (RET) kinase has received increased interest as a therapeutic target for the treatment of thyroid cancer and non-small cell lu...
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Article
Engineering a precise adenine base editor with minimal bystander editing
Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target editing effects raise safety concerns. Through structure-guided engineering, we ...
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Article
Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp3)–C(sp) cross-coupling of tertiary electrophiles with alkynes
In contrast with the well-established enantioconvergent radical C(sp3)–C cross-coupling of racemic secondary alkyl electrophiles, the corresponding coupling of tertiary electrophiles to forge all-carbon quaternar...
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Article
Methanol-induced luminescence vapochromism based on a Sb3+-doped organic indium halide hybrid
Ion do** has been demonstrated as a practical approach to achieving highly efficient luminescence in both inorganic phosphors and organic-inorganic hybrids. The as-formed do** species show great potential ...
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Article
A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA
N6-methyladenosine (6mA) is a DNA modification that has recently been found to play regulatory roles during mammalian early embryo development and mitochondrial transcription. We found that a dioxygenase CcTet f....
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Article
Structural Morphology and Rheological Properties of Pectin Fractions Extracted from Okra Pods Subjected to Cold Plasma Treatment
Cold plasma (CP) is an innovative technology for non-thermal food processing. Low temperature and active particles during CP processing play a significant role in limiting nutrient loss in food and modifying b...
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Article
Inhibitory effects of 3-(methylthio) propyl isothiocyanate in comparison with benzyl isothiocyanate on Listeria monocytogenes
The objective of the current study was to investigate the inhibitory effects of benzyl isothiocyanate (BITC) and 3-(methylthio) propyl isothiocyanate (MTPITC) on Listeria monocytogenes (L. monocytogenes). The com...
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Article
Exploration of the antimicrobial activity of benzyl isothiocyanate against Salmonella enterica serovar Typhimurium
Mounting evidence suggests that benzyl isothiocyanate (BITC), derived from cruciferous vegetables, could be an effective antimicrobial compound against a wide range of food-borne bacteria. This research invest...
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Article
UV soaking for enhancing the photocurrent and response speed of Cs2AgBiBr6-based all-inorganic perovskite photodetectors
The response speed of the reported Cs2AgBiBr6-based photodetectors exhibits a wide variation ranging from microseconds to nanoseconds, while the reason is still unclear. Apart from the conventional approaches suc...
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Article
Chemical Constituents of the Processed Roots of Brassica rapa
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Article
Investigation of Properties of Air-Quenched Steel Slag as Sandblasting Abrasive
In order to effectively improve the environmental problems caused by steel slag stacking, the air-quenching process of molten steel slag was carried out, and the properties of the air-quenched steel slag (AQSS...
