55 Result(s)

Article

Unraveling the Mechanisms of Cannabidiol’s Pharmacological Actions: A Comprehensive Research Overview

Cannabis sativa has long been used for neurological and psychological healing. Recently, cannabidiol (CBD) extracted from cannabis sativa has gained prominence in the medical field due to its non-psychotropic ...

Iqra Kalsoom, Kiran Shehzadi, Han-sheng Li, Hong-liang Wen… in Topics in Current Chemistry (2024)

Article

Lactonization of dyes promoted by a coordination cage facilitates cavity-induced chromism as ion mobile detector

Dye molecules often change colors (so-called “chromism”) according to the environment variation. However, they are rarely induced by a catalytic amount of cavity. Through encapsulation in the cavity of a porou...

Liangliang Zhang, Yu Liang, Zhifeng **ao, Yuxuan Meng… in Science China Chemistry (2024)

Article

Fructose-1,6-bisphosphatase 1 dephosphorylates and inhibits TERT for tumor suppression

Telomere dysfunction is intricately linked to the aging process and stands out as a prominent cancer hallmark. Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cell...

Min Li, Zheng Wang, **g**g Tao, Hongfei Jiang, Huang Yang… in Nature Chemical Biology (2024)

Article

A general copper-catalysed enantioconvergent C(sp³)–S cross-coupling via biomimetic radical homolytic substitution

Although α-chiral C(sp³)–S bonds are of enormous importance in organic synthesis and related areas, the transition-metal-catalysed enantioselective C(sp³)–S bond construction still represents an underdeveloped do...

Yu Tian, **-Tao Li, Ji-Ren Liu, Jian Cheng, Ang Gao, Ning-Yuan Yang… in Nature Chemistry (2024)

Article

Cu-catalysed enantioselective radical heteroatomic S–O cross-coupling

The transition-metal-catalysed cross-coupling reaction has established itself as one of the most reliable and practical synthetic tools for the efficient construction of carbon–carbon/heteroatom (p-block elements...

Yong-Feng Cheng, Zhang-Long Yu, Yu Tian, Ji-Ren Liu, Han-Tao Wen… in Nature Chemistry (2023)

Article

Two New Prenylated Flavonoids from the Leaves of Macaranga pustulata

Two new flavonoids, 8,2′-diprenyl-3,5,7,5′-tetrahydroxyflavone (1) and 8-(1-methoxy-2,3-dihydroxy-3-methylbutyl)naringenin (2), along with twelve known compounds (3–14), were isolated from the leaves of Macaranga...

Joseph Sakah Kaunda, Yuan-Si Chen, Yao-Jun Xu… in Chemistry of Natural Compounds (2023)

Article

A computational study to reveal selpercatinib resistance to RET kinase double mutant V804M/Y806C

As a member of the receptor tyrosine kinase family, rearranged during transfection (RET) kinase has received increased interest as a therapeutic target for the treatment of thyroid cancer and non-small cell lu...

Guodong Zheng, Minyu Li, **gfeng Zhang, Wuxia Liu, Lei Jiang… in Chemical Papers (2023)

Article

Engineering a precise adenine base editor with minimal bystander editing

Adenine base editors (ABEs) catalyze A-to-G transitions showing broad applications, but their bystander mutations and off-target editing effects raise safety concerns. Through structure-guided engineering, we ...

Liang Chen, Shun Zhang, Niannian Xue, Mengjia Hong… in Nature Chemical Biology (2023)

Article

Mechanism-based ligand design for copper-catalysed enantioconvergent C(sp³)–C(sp) cross-coupling of tertiary electrophiles with alkynes

In contrast with the well-established enantioconvergent radical C(sp³)–C cross-coupling of racemic secondary alkyl electrophiles, the corresponding coupling of tertiary electrophiles to forge all-carbon quaternar...

Fu-Li Wang, Chang-Jiang Yang, Ji-Ren Liu, Ning-Yuan Yang… in Nature Chemistry (2022)

Article

A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA

N⁶-methyladenosine (6mA) is a DNA modification that has recently been found to play regulatory roles during mammalian early embryo development and mitochondrial transcription. We found that a dioxygenase CcTet f....

Yajuan Mu, Lin Zhang, **gyan Hu, Jiashen Zhou, Hou-Wen Lin… in Nature Chemical Biology (2022)

Article

Structural Morphology and Rheological Properties of Pectin Fractions Extracted from Okra Pods Subjected to Cold Plasma Treatment

Cold plasma (CP) is an innovative technology for non-thermal food processing. Low temperature and active particles during CP processing play a significant role in limiting nutrient loss in food and modifying b...

Sara Zielinska, Justyna Cybulska, Piotr Pieczywek… in Food and Bioprocess Technology (2022)

Article

Inhibitory effects of 3-(methylthio) propyl isothiocyanate in comparison with benzyl isothiocyanate on Listeria monocytogenes

The objective of the current study was to investigate the inhibitory effects of benzyl isothiocyanate (BITC) and 3-(methylthio) propyl isothiocyanate (MTPITC) on Listeria monocytogenes (L. monocytogenes). The com...

Hong-Yan Wu, Yu-Hang Xu, Li-Na Wei… in Journal of Food Measurement and Characteri… (2022)

Article

Exploration of the antimicrobial activity of benzyl isothiocyanate against Salmonella enterica serovar Typhimurium

Mounting evidence suggests that benzyl isothiocyanate (BITC), derived from cruciferous vegetables, could be an effective antimicrobial compound against a wide range of food-borne bacteria. This research invest...

Hong-Yan Wu, Tong-**n Niu, **g-Ran Bi… in Journal of Food Measurement and Characteri… (2022)

Article

Chemical Constituents of the Processed Roots of Brassica rapa

Guang-Da Li, Hong-Mei Zhao, Rao-Ji ** Puo… in Chemistry of Natural Compounds (2021)

Article

Improving Sustainability of Palm Oil Production by Increasing Oil Extraction Rate: a Review

Palm oil is the world’s most-produced vegetable oil that is serving as an important source of food and energy for many develo** and underdeveloped countries. The global demand for palm oil will continue to r...

Chien Lye Chew, Chun Yong Ng, Wai Onn Hong, Ta Yeong Wu… in Food and Bioprocess Technology (2021)

Article

Synthesis and Cytotoxicity of Heterocyclic Amine Derivatives of Podophyllotoxin

A series of amine podophyllotoxin derivatives was designed and synthesized by aldehydes reacting with 4β-amino-desoxypodophyllotoxin or 4′-demethyldesoxypodophyllotoxin. The MTT assay was used to test the cyto...

Dan-li Tian, Hong Chen, Gang Luo, Chun-po Liang in Chemistry of Natural Compounds (2020)

Article

Development of a Monoclonal Antibody-Based ELISA for the Detection of Alternaria Mycotoxin Tenuazonic Acid in Food Samples

In this study, a specific monoclonal antibody (mAb) against Alternaria mycotoxin tenuazonic acid (TeA) was prepared and a sensitive indirect competitive enzyme-linked immunosorbent assay (ic-ELISA) for the detect...

Yi-Fan Liang, **ao-Wen Zhou, Feng Wang, Yu-Dong Shen… in Food Analytical Methods (2020)

Article

Synthesis and characterization of a novel Schiff base and its enhancement on flame retardancy of epoxy resins

A novel Schiff base, namely N¹,N²-bis{3,4-bis(5,5-dimethyl-2-oxide-1,3,2-dioxaphosphinan-2-yl)oxy]benzylidene}ethane-1,2-diamine (PN), was synthesized by the condensation of 3,4-bis[(5,5-dimethyl-2-oxido-1,3,2-di...

Ge-Yun You, Hong-Wu He, Bin Feng, Yu-Ying Tang, Fang-Fang Fan… in Chemical Papers (2020)