499 Result(s)
within
Hong**a Liu
Science, Humanities and Social Sciences, multidisciplinary
Science, multidisciplinary
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Article
Direct binding of G-protein βλ complex to voltage-dependent calcium channels
Voltage-dependent Ca2+ channels play a central role in controlling neurotransmitter release at the synapse1,2. They can be inhibited by certain G-protein-coupled receptors, acting by a pathway intrinsic to the me...
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Article
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
The tumour microenvironment can be a potent carcinogen, not only by facilitating cancer progression and activating dormant cancer cells, but also by stimulating tumour formation1. We have previously investigated ...
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Sperm chromatin proteomics identifies evolutionarily conserved fertility factors
The identification of conserved proteins important for sperm chromatin structure and packaging can reveal possible causes of male fertility of clinical importance. A proteomics strategy in the nematode Caenorhabd...
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Biodiversity and biogeography of phages in modern stromatolites and thrombolites
Stromatolites are living, layered structures formed in shallow waters by a combination of microbial biofilms — usually of blue-green algae — and granular deposits. They are rare today but for about 2 billion y...
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Article
Bmi1 regulates mitochondrial function and the DNA damage response pathway
Mice deficient in the Polycomb repressor Bmi1 develop numerous abnormalities including a severe defect in stem cell self-renewal, alterations in thymocyte maturation and a shortened lifespan. Previous work has...
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Open AccessThe sequence and de novo assembly of the giant panda genome
Using next-generation sequencing technology alone, we have successfully generated and assembled a draft sequence of the giant panda genome. The assembled contigs (2.25 gigabases (Gb)) cover approximately 94% o...
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Article
Erratum: The sequence and de novo assembly of the giant panda genome
Nature 463, 311–317 (2010) In this Article, the Latin species name of the giant panda was written incorrectly as Ailuropoda melanoleura. The correct name is Ailuropoda melanoleuca.
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Article
The impacts of climate change on water resources and agriculture in China
China, since mid-2010 the world's second biggest economy and tipped to become the biggest in a few decades, has tremendous climatic and ecological diversity. The likely impact of China's economic expansion on ...
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Open AccessSingle molecule detection from a large-scale SERS-active Au79Ag21 substrate
Detecting and identifying single molecules are the ultimate goal of analytic sensitivity. Single molecule detection by surface-enhanced Raman scattering (SM-SERS) depends predominantly on SERS-active metal sub...
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Open AccessA multi-omic map of the lipid-producing yeast Rhodosporidium toruloides
Triacylglycerols are among the most attractive alternative raw materials for biofuel development. Current oil plant-based technologies are limited in terms of triacylglycerol production capacity and rate. Thes...
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Article
Open AccessPhotostable fluorescent organic dots with aggregation-induced emission (AIE dots) for noninvasive long-term cell tracing
Long-term noninvasive cell tracing by fluorescent probes is of great importance to life science and biomedical engineering. For example, understanding genesis, development, invasion and metastasis of cancerous...
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Open AccessBatch-fabricated high-performance graphene Hall elements
Hall elements are by far the most widely used magnetic sensor. In general, the higher the mobility and the thinner the active region of the semiconductor used, the better the Hall device. While most common mag...
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Article
Open AccessTyrosinase as a multifunctional reporter gene for Photoacoustic/MRI/PET triple modality molecular imaging
Development of reporter genes for multimodality molecular imaging is highly important. In contrast to the conventional strategies which have focused on fusing several reporter genes together to serve as multim...
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Article
An isoform of retinoid-related orphan receptor β directs differentiation of retinal amacrine and horizontal interneurons
Amacrine and horizontal interneurons integrate visual information as it is relayed through the retina from the photoreceptors to the ganglion cells. The early steps that generate these interneuron networks rem...
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Article
The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism
Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear FXR. We identify ivermectin us...
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Correction: Corrigendum: A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides
Nature Communications 3: Article number: 1112 (2012); Published: 9 October 2012; Updated: 29 July 2013. The original version of this Article contained a typographical error in the spelling of the author Hanfa ...
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Open AccessQuantitative epigenetic co-variation in CpG islands and co-regulation of developmental genes
The genome-wide variation of multiple epigenetic modifications in CpG islands (CGIs) and the interactions between them are of great interest. Here, we optimized an entropy-based strategy to quantify variation ...
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Article
Open AccessGlobal variation in elevational diversity patterns
While horizontal gradients of biodiversity have been examined extensively in the past, vertical diversity gradients (elevation, water depth) are attracting increasing attention. We compiled data from 443 eleva...
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Open AccessHigh rate capability caused by surface cubic spinels in Li-rich layer-structured cathodes for Li-ion batteries
Modified Li-rich layered cathode Li(Li0.2Mn0.54Ni0.13Co0.13)O2 has been synthesized by a simple strategy of using surface treatment with various amounts (0–30 wt.%) of Super P (carbon black). Based on detailed ch...
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Open AccessFrom Boron Cluster to Two-Dimensional Boron Sheet on Cu(111) Surface: Growth Mechanism and Hole Formation
As attractive analogue of graphene, boron monolayers have been theoretically predicted. However, due to electron deficiency of boron atom, synthesizing boron monolayer is very challenging in experiments. Using...
