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    Article

    High mobility group box 1 enhances hyperthermia-induced seizures and secondary epilepsy associated with prolonged hyperthermia-induced seizures in develo** rats

    Levels of high mobility group box 1 (HMGB1), an important inflammatory mediator, are high in the serum of febrile seizure (FS) patients. However, its roles in FS and secondary epilepsy after prolonged FS are p...

    Masanori Ito, Hisaaki Takahashi, Hajime Yano, Yusuke I. Shimizu… in Metabolic Brain Disease (2017)

  2. No Access

    Article

    Postnatal interleukin-1β administration after experimental prolonged febrile seizures enhances epileptogenesis in adulthood

    It remains unclear whether prolonged febrile seizures (pFS) in childhood facilitate mesial temporal lobe epilepsy (MTLE) in adulthood. Interleukin (IL)-1β is associated with seizures in children and immature a...

    Mitsumasa Fukuda, Masanori Ito, Yoshiaki Yano, Hisaaki Takahashi… in Metabolic Brain Disease (2015)