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    Augmented intrarenal and urinary angiotensinogen in hypertension and chronic kidney disease

    Activated intrarenal renin–angiotensin system plays a cardinal role in the pathogenesis of hypertension and chronic kidney disease. Angiotensinogen is the only known substrate for renin, which is the rate-limi...

    Hiroyuki Kobori, Maki Urushihara in Pflügers Archiv - European Journal of Physiology (2013)