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11 Result(s)

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  1. No Access

    Article

    The Co-Delivery of Oxaliplatin Abrogates the Immunogenic Response to PEGylated siRNA-Lipoplex

    In vivo application of siRNA/PEGylated cationic liposome complex (lipoplex) is impeded by two main obstacles: cytokine responses and anti-PEG IgM responses to PEGylated siRNA-lipoplex. Here, we...

    Eman Alaaeldin, Amr S. Abu Lila, Naoto Moriyoshi… in Pharmaceutical Research (2013)

  2. No Access

    Article

    Targeting Anticancer Drugs to Tumor Vasculature Using Cationic Liposomes

    Liposomal drug delivery systems improve the therapeutic index of chemotherapeutic agents, and the use of cationic liposomes to deliver anticancer drugs to solid tumors has recently been recognized as a promisi...

    Amr S. Abu Lila, Tatsuhiro Ishida, Hiroshi Kiwada in Pharmaceutical Research (2010)

  3. No Access

    Article

    Accelerated Blood Clearance Phenomenon Upon Repeated Injection of PEG-modified PLA-nanoparticles

    We recently developed prostaglandin E1 (PGE1)-encapsulated nanoparticles, prepared with a poly(lactide) homopolymer (PLA, Mw = 17,500) and monomethoxy poly(ethyleneglycol)-PLA block copolymer (PEG-PLA) (NP-L20). ...

    Tsutomu Ishihara, Miho Takeda, Haruka Sakamoto, Ayumi Kimoto… in Pharmaceutical Research (2009)

  4. No Access

    Article

    Effect of Co-administration of Tacrolimus on the Pharmacokinetics of Multiple Subcutaneous Administered Interferon-Alpha in Rats

    Repeated administration of exogenous proteinic compounds triggers the production of specific antibodies. This reaction is limits not only pharmacokinetic studies in animal but also development of human or huma...

    Hiroyuki Yamazaki, Masateru Miyake, Toru Nishibayashi… in Pharmaceutical Research (2009)

  5. No Access

    Chapter

    Unexpected Reactions by In Vivo Applications of PEGylated Liposomes

    PEGylated liposome, a liposome coated with polyethylene glycol (PEG), is understood to be biologically inert and, therefore, a suitable vehicle for in vivo applications. The most successful example is the doxo...

    Tatsuhiro Ishida, Hiroshi Kiwada in Safety of Nanoparticles (2009)

  6. No Access

    Article

    Global Gene Expression Profiling in Cultured Cells Is Strongly Influenced by Treatment with siRNA–Cationic Liposome Complexes

    The purpose of this study is to determine if the treatment with siRNA-lipoplexes significantly influences on global gene expression in the treated cells.

    Tatsuaki Tagami, Kiyomi Hirose, Jose Mario Barichello… in Pharmaceutical Research (2008)

  7. No Access

    Article

    Quantitative Analysis of Correlation Between Number of Nuclear Plasmids and Gene Expression Activity After Transfection with Cationic Liposomes

    Purpose. A quantitative understanding of the intracellular trafficking of plasmids delivered by nonviral vectors is essential for optimizing vector functions to increase their transfection efficiency. In this st...

    Rieko Tachibana, Hideyoshi Harashima, Naoko Ide, Sachiko Ukitsu… in Pharmaceutical Research (2002)

  8. No Access

    Article

    Plasma Factor Triggering Alternative Complement Pathway Activation by Liposomes

    Several plasma components, such as complement (C) components, play a role in the clearance of liposomes from the circulation. The interactions between liposomes and the C system were investigated in this study...

    Kouichi Funato, Chikamasa Yamashita, Junko Kamada… in Pharmaceutical Research (1994)

  9. No Access

    Article

    Enhanced Hepatic Uptake of Liposomes Through Complement Activation Depending on the Size of Liposomes

    The objective of this study was to differentiate the roles of opsonins and phagocytic cells in the size-dependent hepatic uptake of liposomes in the submicron region. The extent of opsonization decreased with ...

    Hideyoshi Harashima, Kazuya Sakata, Kouichi Funato… in Pharmaceutical Research (1994)

  10. No Access

    Article

    Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency

    The objective of this study was to examine the AUCdependency of saturable hepatic clearance (CL h )of liposomes and to postulate a mathematical model to describe the characteris...

    Hideyoshi Harashima, Chizu Yamane… in Journal of Pharmacokinetics and Biopharmac… (1993)

  11. No Access

    Article

    Distinction Between the Depletion of Opsonins and the Saturation of Uptake in the Dose-Dependent Hepatic Uptake of Liposomes

    Opsonins play a role in the hepatic uptake of particles such as bacteria, lipid emulsion, and liposomes. The objective of this study was to distinguish between opsonin depletion and uptake saturation in the do...

    Hideyoshi Harashima, Kazuya Sakata, Hiroshi Kiwada in Pharmaceutical Research (1993)