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Article
Pathological findings of liver steatosis that is difficult to evaluate with ultrasound
Although new ultrasound (US) methods able to quantitatively assess liver fat content have been recently developed, B-mode US is still the major method for detecting liver steatosis during medical checkups. How...
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Article
Open AccessNeonatal intrahepatic cholestasis caused by citrin deficiency with no hepatic steatosis: a case report
Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is a common form of neonatal jaundice. Histopathological examination of the liver in patients with NICCD typically shows fatty liver, steat...
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Article
ER staining levels affect HER2 staining and heterogeneity
This study explored the relationship of ER expression levels with HER2 staining properties and heterogeneity and discussed the differences in HER2 assessment caused by the 2018 ASCO/CAP guideline updates from ...
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Chapter
Pathology of Biliary Atresia
Biliary atresia (BA) displays characteristic pathological findings of the liver and choledochus in the hepatic hilum [1–4]. We will discuss them and compare them with the liver histological features in other t...
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Article
Androgen receptor expression is useful to predict the therapeutic effect in HER2-positive breast carcinoma
Although HER2-positive (HER2+) invasive breast carcinomas (BC) have a different clinical therapeutic responsiveness according to estrogen and progesterone receptor expression, the relationship with androgen re...
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Article
Histopathological findings of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis
Nonalcoholic fatty liver disease (NAFLD) is based on the concept of pathological morphology as well as clinical findings, and is broadly categorized into nonalcoholic fatty liver (NAFL) and nonalcoholic steato...
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Article
Open AccessEffect of food on the pharmacokinetics and therapeutic efficacy of 4-phenylbutyrate in progressive familial intrahepatic cholestasis
Progressive familial intrahepatic cholestasis (PFIC), a rare inherited disorder, progresses to liver failure in childhood. We have shown that sodium 4-phenylbutyrate (NaPB), a drug approved for urea cycle diso...
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Article
High sulfite oxidase expression could predict postoperative biochemical recurrence in patients with prostate cancer
Sulfite oxidase (SUOX) is a metalloenzyme that plays a role in ATP synthesis via oxidative phosphorylation in mitochondria and has been reported to also be involved in the invasion and differentiation capaciti...
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Article
Open AccessIntrabiliary growth type of metastasis from colon cancer, 12 years after curative colectomy: a case report
Liver is a common location of colorectal metastasis, but intrabiliary growth of liver metastasis is not well recognized. Furthermore, intrabiliary metastasis that discovered over 10 years after excision has ra...
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Article
Open AccessInfantile-onset inflammatory bowel disease in a patient with Hermansky-Pudlak syndrome: a case report
Hermansky-Pudlak syndrome (HPS) is a rare, genetically heterogeneous disorder that manifests oculocutaneous albinism together with bleeding diatheses that reflect a platelet storage pool deficiency. Ten geneti...
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Article
Open AccessNovel neuroblastoma amplified sequence (NBAS) mutations in a Japanese boy with fever-triggered recurrent acute liver failure
Biallelic mutations in the neuroblastoma amplified sequence (NBAS) gene have been reported to cause two different clinical spectra: short stature with optic nerve atrophy and Pelger-Huët anomaly (SOPH) syndrome a...
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Article
Insulinoma-associated protein 1 (INSM1) is a useful marker for pancreatic neuroendocrine tumor
Insulinoma-associated protein 1 (INSM1) is an important biomarker of Achaete-scute homolog-like 1-driven pathways. For diagnosis of pancreatic neuroendocrine tumors (PanNET), chromogranin A (CGA), synaptophysi...
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Article
Multi-centric pancreatic cancer without PanIN lesion
The patient was a 67-year-old man under follow-up after gastric cancer surgery. An abdominal CT scan performed 1 year earlier had shown an approximately 14-mm hypovascular mass in the pancreatic body; however,...
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Article
Pathomorphologic study of undifferentiated carcinoma in seven cases: relationship between tumor and pancreatic duct epithelium
By the time undifferentiated carcinoma is detected, it has formed a large mass, and it is reportedly difficult to pathologically observe its relationship with the pancreatic duct. In this study, we examined th...
