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Article
Open AccessPrognostic significance of chronic kidney disease and impaired renal function in Japanese patients with COVID-19
Renal impairment is a predictor of coronavirus disease (COVID-19) severity. No studies have compared COVID-19 outcomes in patients with chronic kidney disease (CKD) and patients with impaired renal function wi...
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Article
Prognostic significance of hypertension history and blood pressure on admission in Japanese patients with coronavirus disease 2019: integrative analysis from the Japan COVID-19 Task Force
The effect of preexisting hypertension on coronavirus disease 2019 (COVID-19) prognosis remains controversial. Additionally, no studies have compared the association between blood pressure (BP) indices on admi...
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Article
Open AccessCharacteristics of patients with COVID-19 who have deteriorating chest X-ray findings within 48 h: a retrospective cohort study
The severity of chest X-ray (CXR) findings is a prognostic factor in patients with coronavirus disease 2019 (COVID-19). We investigated the clinical and genetic characteristics and prognosis of patients with w...
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Article
Association between ABO blood group/genotype and COVID-19 in a Japanese population
An association between coronavirus disease 2019 (COVID-19) and the ABO blood group has been reported. However, such an association has not been studied in the Japanese population on a large scale. Little is kn...
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Article
Open AccessHealthcare costs for hospitalized COVID-19 patients in a Japanese university hospital: a cross-sectional study
A health-economic evaluation related to COVID-19 is urgently needed to allocate healthcare resources efficiently; however, relevant medical cost data in Japan concerning COVID-19 are scarce.
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Article
Open AccessLongitudinal significance of six-minute walk test in patients with nontuberculous mycobacterial pulmonary disease: an observational study
The long-term exercise tolerance changes in patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) are of great interest because of its chronic course. This study aimed to characterize the assoc...
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Article
Open AccessImpact of respiratory bacterial infections on mortality in Japanese patients with COVID-19: a retrospective cohort study
Although cases of respiratory bacterial infections associated with coronavirus disease 2019 (COVID-19) have often been reported, their impact on the clinical course remains unclear. Herein, we evaluated and an...
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Article
Open AccessCharacteristics of hospitalized patients with COVID-19 during the first to fifth waves of infection: a report from the Japan COVID-19 Task Force
We aimed to elucidate differences in the characteristics of patients with coronavirus disease 2019 (COVID-19) requiring hospitalization in Japan, by COVID-19 waves, from conventional strains to the Delta variant.
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Open AccessImpact of upper and lower respiratory symptoms on COVID-19 outcomes: a multicenter retrospective cohort study
Respiratory symptoms are associated with coronavirus disease 2019 (COVID-19) outcomes. However, the impacts of upper and lower respiratory symptoms on COVID-19 outcomes in the same population have not been com...
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Article
Open AccessDifferences in lung and lobe volumes between supine and upright computed tomography in patients with idiopathic lung fibrosis
No clinical study has compared lung or lobe volumes on computed tomography (CT) between the supine and standing positions in patients with idiopathic lung fibrosis (IPF). This study aimed to compare lung and l...
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Article
Open AccessClinical clustering with prognostic implications in Japanese COVID-19 patients: report from Japan COVID-19 Task Force, a nation-wide consortium to investigate COVID-19 host genetics
The clinical course of coronavirus disease (COVID-19) is diverse, and the usefulness of phenoty** in predicting the severity or prognosis of the disease has been demonstrated overseas. This study aimed to in...
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Article
Open AccessDOCK2 is involved in the host genetics and biology of severe COVID-19
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge1–5. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of COVID-19 in a cohort of Japanese indi...
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Open AccessThe whole blood transcriptional regulation landscape in 465 COVID-19 infected samples from Japan COVID-19 Task Force
Coronavirus disease 2019 (COVID-19) is a recently-emerged infectious disease that has caused millions of deaths, where comprehensive understanding of disease mechanisms is still unestablished. In particular, s...
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Article
Open AccessEffects of mild obesity on outcomes in Japanese patients with COVID-19: a nationwide consortium to investigate COVID-19 host genetics
Obesity is reported to be a risk factor for severe disease in patients with coronavirus disease 2019 (COVID-19). However, there are no specific reports on the risk of severe disease according to body mass inde...
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Article
Open AccessOsteoporosis in nontuberculous mycobacterial pulmonary disease: a cross-sectional study
Since nontuberculous mycobacterial pulmonary disease (NTM-PD) is common in middle-aged/elderly slender women at risk of osteoporosis, we hypothesized that NTM-PD could be associated with osteoporosis. The stud...
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Article
Open AccessAssociation between six-minute walk test parameters and the health-related quality of life in patients with pulmonary Mycobacterium avium complex disease
Pulmonary Mycobacterium avium complex (pMAC) disease is a chronic, slowly progressive disease. The aim of the present study was to determine the association of six-minute walk test (6MWT) parameters with pulmonar...
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Article
Removal of fluoride by effectively using spent cation exchange resin
Spent strongly acidic cation exchange resin was effectively used for the removal of trace concentration of fluoride ions. For this purpose, the spent resins were pulverized into fine powders to be used togethe...
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Article
Open AccessImpact of chronic Pseudomonas aeruginosa infection on health-related quality of life in Mycobacterium avium complex lung disease
In bronchiectasis patients, chronic Pseudomonas aeruginosa (PA) infection has been associated with worse health-related quality of life (HRQL), but little is known about Mycobacterium avium complex lung disease (...
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Article
Open AccessIntratracheal synthetic CpG oligodeoxynucleotide causes acute lung injury with systemic inflammatory response
Bacterial genome is characterized by frequent unmethylated cytosine-phosphate-guanine (CpG) motifs. Deleterious effects can occur when synthetic oligodeoxynucleotides (ODN) with unmethylated CpG dinucleotides ...
