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22 Result(s)
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Hildegund C.J. Ertl
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Article
Mitigating Serious Adverse Events in Gene Therapy with AAV Vectors: Vector Dose and Immunosuppression
Gene transfer with high doses of adeno-associated viral (AAV) vectors has resulted in serious adverse events and even death of the recipients. Toxicity could most likely be circumvented by repeated injections ...
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Chapter
Historical Progression from Nerve Tissue-Based Rabies Vaccines to Recombinant Biologics for Humans and Companion Animals
Annually, vaccines against infectious agents prevent countless cases of human misery and death. One of the first vaccines that was developed and tested in humans was against rabies, an infectious disease which...
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Article
PD-1 directed immunotherapy alters Tfh and humoral immune responses to seasonal influenza vaccine
Anti-programmed death-1 (anti-PD-1) immunotherapy reinvigorates CD8 T cell responses in patients with cancer but PD-1 is also expressed by other immune cells, including follicular helper CD4 T cells (Tfh) whic...
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Article
Open AccessHepatitis B virus polymerase-specific T cell epitopes shift in a mouse model of chronic infection
Chronic hepatitis B virus (HBV) infection (CHB) is a significant public health problem that could benefit from treatment with immunomodulators. Here we describe a set of therapeutic HBV vaccines that target th...
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Chapter
Novel Rabies Vaccines
Novel rabies vaccines that are less expensive and more immunogenic than current vaccines are needed to reduce the human death toll of rabies. Such vaccines would also allow for more widespread use of rabies va...
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Article
Safety and immunogenicity of a potential checkpoint blockade vaccine for canine melanoma
Human immunotherapy with checkpoint blockades has achieved significant breakthroughs in recent years. In this study, a checkpoint blockade vaccine for canine melanoma was tested for safety and immunogenicity. ...
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Article
Open AccessImmune response to influenza vaccination in the elderly is altered by chronic medication use
The elderly patient population is the most susceptible to influenza virus infection and its associated complications. Polypharmacy is common in the aged, who often have multiple co-morbidities. Previous studie...
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Article
Open AccessPrime-boost vaccination with recombinant protein and adenovirus-vector expressing Plasmodium vivax circumsporozoite protein (CSP) partially protects mice against Pb/Pv sporozoite challenge
Vaccine development against Plasmodium vivax malaria lags behind that for Plasmodium falciparum. To narrow this gap, we administered recombinant antigens based on P. vivax circumsporozoite protein (CSP) to mice. ...
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Protocol
Vaccine Design: Replication-Defective Adenovirus Vectors
Replication-defective adenovirus (Ad) vectors were initially developed for gene transfer for correction of genetic diseases. Although Ad vectors achieved high levels of transgene product expression in a variet...
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Book
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Article
An efficient method of directly cloning chimpanzee adenovirus as a vaccine vector
Adenoviral vectors have shown great promise as vaccine carriers and in gene transfer to correct underlying genetic diseases. Traditionally, cstruction of adenoviral vectors is complex and time consuming. In th...
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Article
Correction: Corrigendum: Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells
Nat. Med. 15, 876–878 (2009); published online 20 July 2009; corrected after print 5 November 2009 In the version of this article initially published, George Makedonas was omitted from the author list. The err...
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Article
Baseline Ad5 serostatus does not predict Ad5 HIV vaccine–induced expansion of adenovirus-specific CD4+ T cells
The phase 2b trial of Merck's recombinant adenovirus type 5-based HIV-1 vaccine was halted as the vaccine seemed to have increased HIV-1 acquisition in vaccine recipients who had preexisting immunity to the ad...
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Chapter
Pandemic Influenza Vaccines
Since their compositions remain uncertain, universal pandemic vaccines are yet to be created. They would aim to protect globally against pandemic influenza viruses that have not yet evolved. Thus they differ f...
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Article
CD8+ T-cell responses to adeno-associated virus capsid in humans
Hepatic adeno-associated virus (AAV)-serotype 2 mediatedgene transfer results in transgene product expression that is sustained in experimental animals but not in human subjects. We hypothesize that this is ca...
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Article
DNA vaccines against the human papillomavirus type 16 E6 or E7 oncoproteins
DNA vaccines expressing the E6 or E7 oncoproteins of human papilloma virus type 16 (HPV-16) in either their wild-type form or fused to sequences that affect intracellular trafficking were tested for induction ...
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Chapter
Low scale multiple array synthesis and DNA hybridization of peptide nucleic acids
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Chapter
Phosphopeptide models of the C-terminal basic domain of p53
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Chapter
In situ identification of T helper cell epitopes from a cellulose-bound peptide array
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Chapter
The Natural T-Helper Cell Epitope Repertoire is Unlikely to Contain Glycopeptides with Extended Carbohydrate Side-Chains
To answer the question whether or not the natural T-cell epitope repertoire contains glycosylated antigens, we synthesized a series of glycopeptides corresponding to peptide 31 D, a major T-helper cell epitope...
