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  1. No Access

    Protocol

    Isolation and Mass Spectrometry-Based Profiling of Major Lipids in Brown Adipose Tissue

    Brown adipose tissue (BAT) is an important regulator of metabolic homeostasis through its role in adaptive thermogenesis and control of whole-body glucose metabolism. Lipids play multiple roles in BAT function...

    Dongliang Lu, Hideji Fujiwara, Irfan J. Lodhi, Fong-Fu Hsu in Thermogenic Fat (2023)

  2. Article

    Open Access

    Author Correction: Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

    Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan… in Nature Communications (2021)

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  3. Article

    Open Access

    A human iPSC-derived inducible neuronal model of Niemann-Pick disease, type C1

    Niemann-Pick disease, type C (NPC) is a childhood-onset, lethal, neurodegenerative disorder caused by autosomal recessive mutations in the genes NPC1 or NPC2 and characterized by impaired cholesterol homeostasis,...

    Anika V. Prabhu, Insung Kang, Raffaella De Pace, Christopher A. Wassif… in BMC Biology (2021)

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  4. Article

    Open Access

    Loss of SNORA73 reprograms cellular metabolism and protects against steatohepatitis

    Dyslipidemia and resulting lipotoxicity are pathologic signatures of metabolic syndrome and type 2 diabetes. Excess lipid causes cell dysfunction and induces cell death through pleiotropic mechanisms that link...

    Arthur C. Sletten, Jessica W. Davidson, Busra Yagabasan… in Nature Communications (2021)

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  5. No Access

    Article

    Early-onset metabolic syndrome in mice lacking the intestinal uric acid transporter SLC2A9

    Excess circulating uric acid, a product of hepatic glycolysis and purine metabolism, often accompanies metabolic syndrome. However, whether hyperuricaemia contributes to the development of metabolic syndrome o...

    Brian J DeBosch, Oliver Kluth, Hideji Fujiwara, Annette Schürmann… in Nature Communications (2014)

  6. No Access

    Article

    Homo-timeric structural model of human microsomal prostaglandin E synthase-1 and characterization of its substrate/inhibitor binding interactions

    Inducible, microsomal prostaglandin E synthase 1 (mPGES-1), the terminal enzyme in the prostaglandin (PG) biosynthetic pathway, constitutes a promising therapeutic target for the development of new anti-inflam...

    Li **ng, Ravi G. Kurumbail, Ronald B. Frazier… in Journal of Computer-Aided Molecular Design (2009)

  7. No Access

    Article

    T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation

    Glucocorticoids, acting through the glucocorticoid receptor, potently modulate immune function and are a mainstay of therapy for treatment of inflammatory conditions, autoimmune diseases, leukemias and lymphomas1

    Judson A Brewer, Bernard Khor, Sherri K Vogt, Lisa M Muglia… in Nature Medicine (2003)