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Article
Open AccessPrevalence of potentially harmful multidrug interactions on medication lists of elderly ambulatory patients
It has been hypothesized that polypharmacy may increase the frequency of multidrug interactions (MDIs) where one drug interacts with two or more other drugs, amplifying the risk of associated adverse drug even...
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Article
Open AccessMonitoring prescribing patterns using regression and electronic health records
It is beneficial for health care institutions to monitor physician prescribing patterns to ensure that high-quality and cost-effective care is being provided to patients. However, detecting treatment patterns ...
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Article
Open AccessEarly recognition of multiple sclerosis using natural language processing of the electronic health record
Diagnostic accuracy might be improved by algorithms that searched patients’ clinical notes in the electronic health record (EHR) for signs and symptoms of diseases such as multiple sclerosis (MS). The focus th...
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Article
Open AccessPresence of early CKD-related metabolic complications predict progression of stage 3 CKD: a case-controlled study
Only a subset of patients who enter stage 3 chronic kidney disease (CKD) progress to stage 4. Identifying which patients entering stage 3 are most likely to progress could improve outcomes, by allowing more ap...
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Article
Open AccessVitamin D resistance in chronic kidney disease (CKD)
Previous studies have shown that treatment with ergocalciferol in patients with CKD stage 3 + 4 is not effective with less than 33% of patients achieving a 25-OH vitamin D target of >30 ng/ml. The aim of this ...
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Article
Open AccessMining multi-item drug adverse effect associations in spontaneous reporting systems
Multi-item adverse drug event (ADE) associations are associations relating multiple drugs to possibly multiple adverse events. The current standard in pharmacovigilance is bivariate association analysis, where...
