30 Result(s)

Article

Effect of metabolically divergent pig breeds and tissues on mesenchymal stem cell expression patterns during adipogenesis

Unraveling the intricate and tightly regulated process of adipogenesis, involving coordinated activation of transcription factors and signaling pathways, is essential for addressing obesity and related metabol...

Siriluck Ponsuksili, Puntita Siengdee, Shuaichen Li… in BMC Genomics (2024)

Article

New insights into the genetic predisposition of brucellosis and its effect on the gut and vaginal microbiota in goats

Goats contribute significantly to the global food security and industry. They constitute a main supplier of meat and milk for large proportions of people in Egypt and worldwide. Brucellosis is a zoonotic infec...

Ahmed M. Sallam, Ibrahim Abou-souliman, Henry Reyer, Klaus Wimmers… in Scientific Reports (2023)

Article

Genome-wide landscape of runs of homozygosity and differentiation across Egyptian goat breeds

Understanding the genomic features of livestock is essential for successful breeding programs and conservation. This information is scarce for local goat breeds in Egypt. In the current study, genomic regions ...

Ahmed M. Sallam, Henry Reyer, Klaus Wimmers, Francesca Bertolini… in BMC Genomics (2023)

Article

Transcriptome changes during osteogenesis of porcine mesenchymal stem cells derived from different types of synovial membranes and genetic background

Synovial membrane mesenchymal stem cells (SMSCs) often serve as in vitro model for bone disease, but the molecular mechanisms driving osteogenesis in SMSCs from different donor cells of various sources and bre...

Shuaichen Li, Puntita Siengdee, Michael Oster, Henry Reyer… in Scientific Reports (2023)

Article

Author Correction: Genomic characterization of the world’s longest selection experiment in mouse reveals the complexity of polygenic traits

Sergio E. Palma-Vera, Henry Reyer, Martina Langhammer, Norbert Reinsch… in BMC Biology (2022)

Article

Genetic regulation and variation of expression of miRNA and mRNA transcripts in fetal muscle tissue in the context of sex, dam and variable fetal weight

Impaired skeletal muscle growth in utero can result in reduced birth weight and pathogenesis of intrauterine growth restriction. Fetal and placental growth is influenced by many factors including genetic, epig...

Siriluck Ponsuksili, Eduard Murani, Frieder Hadlich… in Biology of Sex Differences (2022)

Article

Dietary intervention improves health metrics and life expectancy of the genetically obese Titan mouse

Suitable animal models are essential for translational research, especially in the case of complex, multifactorial conditions, such as obesity. The non-inbred mouse (Mus musculus) line Titan, also known as DU6, i...

Annika Müller-Eigner, Adrián Sanz-Moreno, Irene de-Diego… in Communications Biology (2022)

Article

Genomic characterization of the world’s longest selection experiment in mouse reveals the complexity of polygenic traits

Long-term selection experiments are a powerful tool to understand the genetic background of complex traits. The longest of such experiments has been conducted in the Research Institute for Farm Animal Biology ...

Sergio E. Palma-Vera, Henry Reyer, Martina Langhammer, Norbert Reinsch… in BMC Biology (2022)

Article

Jejunal transcriptomic profiling of two layer strains throughout the entire production period

The jejunum plays crucial roles for the digestion and absorption of nutrients and minerals and for barrier functions that are essential for a healthy, productive life cycle of farm animals, including laying he...

Adewunmi Omolade Omotoso, Henry Reyer, Michael Oster… in Scientific Reports (2021)

Article

Transcriptional responses in jejunum of two layer chicken strains following variations in dietary calcium and phosphorus levels

Calcium (Ca) and phosphorus (P) are essential nutrients that are linked to a large array of biological processes. Disturbances in Ca and P homeostasis in chickens are associated with a decline in growth and eg...

Henry Reyer, Michael Oster, Siriluck Ponsuksili, Nares Trakooljul… in BMC Genomics (2021)

Article

Dietary phosphorus and calcium in feed affects miRNA profiles and their mRNA targets in jejunum of two strains of laying hens

Phosphorus (P) and calcium (Ca) are critical for egg production in laying hens. Most of P in plant-based poultry diet is bound as phytic acid and needs to be hydrolysed before absorption. To increase P bioavai...

Muhammad Arsalan Iqbal, Asghar Ali, Frieder Hadlich, Michael Oster… in Scientific Reports (2021)

Article

Reduced phosphorus intake throughout gestation and lactation of sows is mitigated by transcriptional adaptations in kidney and intestine

The environmental impact of pig farming need to be reduced, with phosphorus (P) being of particular interest. Specified dietary regimens and management systems contribute to meet environmental concerns and red...

Aisanjiang Wubuli, Christian Gerlinger, Henry Reyer, Michael Oster… in BMC Genomics (2020)

Article

Design of experiments for fine-map** quantitative trait loci in livestock populations

Single nucleotide polymorphisms (SNPs) which capture a significant impact on a trait can be identified with genome-wide association studies. High linkage disequilibrium (LD) among SNPs makes it difficult to id...

Dörte Wittenburg, Sarah Bonk, Michael Doschoris, Henry Reyer in BMC Genetics (2020)

Article

High-density genoty** reveals signatures of selection related to acclimation and economically important traits in 15 local sheep breeds from Russia

Domestication and centuries of selective breeding have changed genomes of sheep breeds to respond to environmental challenges and human needs. The genomes of local breeds, therefore, are valuable sources of ge...

Andrey A. Yurchenko, Tatiana E. Deniskova, Nikolay S. Yudin… in BMC Genomics (2019)

Article

Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation

Genome wide association study was conducted using a mixed linear model (MLM) approach that accounted for family structure to identify single nucleotide polymorphisms (SNPs) and candidate genes associated with ...

Wossenie Mebratie, Henry Reyer, Klaus Wimmers, Henk Bovenhuis… in Scientific Reports (2019)

Article

RNA-seq of muscle from pigs divergent in feed efficiency and product quality identifies differences in immune response, growth, and macronutrient and connective tissue metabolism

Feed efficiency (FE) is an indicator of efficiency in converting energy and nutrients from feed into a tissue that is of major environmental and economic significance. The molecular mechanisms contributing to ...

Justyna Horodyska, Klaus Wimmers, Henry Reyer, Nares Trakooljul… in BMC Genomics (2018)

Article

Transcriptional shifts account for divergent resource allocation in feed efficient broiler chickens

Considerable variation in feed efficiency (FE) has been observed in indigenous and selected meat-type chicken populations. Although this variation could be partially linked to extrinsic factors like diet, hous...

Henry Reyer, Barbara U. Metzler-Zebeli, Nares Trakooljul… in Scientific Reports (2018)

Article

Genetic variants of major genes contributing to phosphate and calcium homeostasis and their association with serum parameters in pigs

Calcium and phosphorus are irreplaceable components of life. Tracking the fate of calcium and phosphorus in organisms deserves high attention due to their relevance in bone metabolism and subsequently animal h...

Franziska Just, Henry Reyer, Eduard Muráni… in Journal of Applied Genetics (2018)