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    Article

    An improved in vitro photochemical internalization protocol for 3D spheroid cultures

    Photochemical internalization (PCI) is a modified form of photodynamic therapy (PDT) that enhances the efficacy of therapeutic agents in a site and temporal specific manner in both in vitro and in vivo publica...

    Lina Nguyen, Steen J. Madsen, Kristian Berg, Henry Hirschberg in Lasers in Medical Science (2021)

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    Photosensitizer delivery by fibrin glue: potential for bypassing the blood-brain barrier

    Fibrin glue (FG) has potential as a delivery vehicle for photosensitizer directly to the resection cavity, so it may bypass the blood-brain barrier (BBB) and increase the concentration of successfully delivere...

    Lina Nguyen, Eric O. Potma, Jimmy N. Le, Julie Johnson in Lasers in Medical Science (2021)

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    Enhancing the effects of chemotherapy by combined macrophage-mediated photothermal therapy (PTT) and photochemical internalization (PCI)

    Light-based treatment modalities such as photothermal therapy (PTT) or photochemical internalization (PCI) have been well documented both experimentally and clinically to enhance the efficacy of chemotherapy. ...

    Rohit Kumar Nair, Catherine Christie, David Ju, Diane Shin in Lasers in Medical Science (2018)

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    Nanoparticle-loaded macrophage-mediated photothermal therapy: potential for glioma treatment

    Gold-based nanoparticles have been used in a number of therapeutic and diagnostic applications. The purpose of this study was to investigate the efficacy of gold–silica nanoshells (AuNS) in photothermal therap...

    Steen J. Madsen, Catherine Christie, Seok ** Hong in Lasers in Medical Science (2015)