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Article
Open AccessPhotocatalytic-treated asphalt road in Copenhagen for urban \(\text{NO}_{x}\) removal
Atmospheric nitrogen oxides ( \(\hbox {NO}_{x} = \hbox {NO}+\hbox {NO}_{2}\) ...
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Article
Open AccessLongitudinal telomere dynamics within natural lifespans of a wild bird
Telomeres, the nucleotide sequences that protect the ends of eukaryotic chromosomes, shorten with each cell division and telomere loss may be influenced by environmental factors. Telomere length (TL) decreases...
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Article
Open AccessInbreeding is associated with shorter early-life telomere length in a wild passerine
Inbreeding can have negative effects on survival and reproduction, which may be of conservation concern in small and isolated populations. However, the physiological mechanisms underlying inbreeding depression...
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Article
Open AccessAssessment of immunogenicity and drug activity in patient sera by flow-induced dispersion analysis
Biopharmaceuticals have revolutionized the treatment of many diseases such as diabetes, cancer, and autoimmune disorders. These complex entities provide unique advantages like high specificity towards their ta...
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Article
Open AccessCapillary flow experiments for thermodynamic and kinetic characterization of protein liquid-liquid phase separation
Liquid-liquid phase separation or LLPS of proteins is a field of mounting importance and the value of quantitative kinetic and thermodynamic characterization of LLPS is increasingly recognized. We present a me...
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Article
Open AccessSize-based characterization of adalimumab and TNF-α interactions using flow induced dispersion analysis: assessment of avidity-stabilized multiple bound species
The understanding and characterization of protein interactions is crucial for elucidation of complicated biomolecular processes as well as for the development of new biopharmaceutical therapies. Often, protein...
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Article
Open AccessMulti-generational genetic consequences of reinforcement in a bird metapopulation
Translocation of conspecific individuals to reduce extinction risk of small, isolated populations and prevent genetic depletion is a powerful tool in conservation biology. An important question is how the tran...
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Article
Medication Tracking: Design and Fabrication of a Dry Powder Inhaler with Integrated Acoustic Element by 3D Printing
Asthma is a prevalent lung disorder that cause heavy burdens globally. Inhalation medicaments can relieve symptoms, improve lung function and, thus, the quality of life. However, it is well-documented that pat...
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Article
Open AccessAnimal models with group-specific additive genetic variances: extending genetic group models
The animal model is a key tool in quantitative genetics and has been used extensively to estimate fundamental parameters, such as additive genetic variance or heritability. An implicit assumption of animal models...
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Protocol
Flow-Induced Dispersion Analysis (FIDA) for Protein Quantification and Characterization
Flow-Induced Dispersion Analysis (FIDA) enables characterization and quantification of proteins under native conditions. FIDA is based on measuring the change in size of a ligand as it selectively interacts wi...
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The Implications of Programmatic Advertising on the Business Model of TV Broadcasters
Technological changes produced by the digital convergence are driving a paradigm shift in advertising and mass communication, and resulting in the emergence of a new market. Programmatic advertising is, in thi...
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Chapter
Capillary-Based Techniques for Physical-Chemical Characterization of Drug Substances and Drug Delivery Systems
Physical chemical characterization of drug compounds and drug delivery systems is challenging when the amount of material for analysis is limited. Capillary-based methodologies based on capillary electrophores...
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Protocol
On-Chip Electromembrane Extraction for Monitoring Drug Metabolism in Real Time by Electrospray Ionization Mass Spectrometry
Sample preparation is an essential step in any bioanalytical procedure and very often the most challenging step in method development. Most of the currently used methods require a relatively large amount of sa...
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Article
Determination of stability constants of tauro- and glyco-conjugated bile salts with the negatively charged sulfobutylether-β-cyclodextrin: comparison of affinity capillary electrophoresis and isothermal titration calorimetry and thermodynamic analysis of the interaction
The aim of the present work was to investigate the interaction between bile salts present in the intestine of man, dog and rat with the negatively charged cyclodextrin (CD), sulfobutylether-β-cyclodextrin (SBE...
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Article
Open AccessCardiac magnetic resonance of acute atrial ablation injury - impact of catheter-myocardium contact force
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Development and characterization of a small electromembrane extraction probe coupled with mass spectrometry for real-time and online monitoring of in vitro drug metabolism
A small and very simple electromembrane extraction probe (EME-probe) was developed and coupled directly to electrospray ionization mass spectrometry (ESI-MS), and this system was used to monitor in real time i...
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Article
Extra-pair paternity in relation to regional and local climate in an Arctic-breeding passerine
Reproductive processes are affected by local and regional climate variation. Birds breeding in the Arctic may experience strong energetic constraints, which will affect their reproductive output. Recent resear...
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Article
A New Approach to Dissolution Testing by UV Imaging and Finite Element Simulations
Most dissolution testing systems rely on analyzing samples taken remotely from the dissolving sample surface at different time points with poor time resolution and therefore provide relatively unresolved tempo...
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Article
Correlates of egg size variation in a population of house sparrow Passer domesticus
Propagule size represents an important life-history trait under maternal control. Despite a positive relationship between propagule size and components of fitness, propagule size displays tremendous amounts of...
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Article
Open AccessDual-IR late gadolinium enhancement achieves better blood suppression than traditional IR in a swine model of atrial radiofrequency ablation scar
