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Article
Inhaled SARS-CoV-2 vaccine for single-dose dry powder aerosol immunization
The COVID-19 pandemic has fostered major advances in vaccination technologies1–4; however, there are urgent needs for vaccines that induce mucosal immune responses and for single-dose, non-invasive administration
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Article
Open AccessPreparation of a Klebsiella pneumoniae conjugate nanovaccine using glycol-engineered Escherichia coli
Engineered strains of Escherichia coli have been used to produce bioconjugate vaccines using Protein Glycan Coupling Technology (PGCT). Nanovaccines have also entered the vaccine development arena with advances i...
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Article
Open AccessBioinformatic analysis of structures and encoding genes of Escherichia coli surface polysaccharides sheds light on the heterologous biosynthesis of glycans
Surface polysaccharides (SPs), such as lipopolysaccharide (O antigen) and capsular polysaccharide (K antigen), play a key role in the pathogenicity of Escherichia coli (E. coli). Gene cluster for polysaccharide a...
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Article
Orthogonal modular biosynthesis of nanoscale conjugate vaccines for vaccination against infection
Conjugate vaccines represent one of the most effective means for controlling the occurrence of bacterial diseases. Although nanotechnology has been greatly applied in the field of vaccines, it is seldom used f...
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Article
Design of Dual-Frequency Plasmonic Photo-Coupler for Infrared Phototransistors
Infrared phototransistors with very high performance show great potential in optoelectronic application, attributable to the intrinsic high transconductive gain of the transistor structure and therefore very ...
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Article
Rapid and Highly Sensitive Detection of Toxigenic Vibrio cholerae Based on Recombinase-Aided Amplification Combining with Lateral Flow Assay
Vibrio cholerae is an important food-borne pathogenic bacterium that causes human disease, resulting in economic losses worldwide. Rapid diagnosis of cholera infection is important to avoid potential spread of di...
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Article
Recent Advance of Tellurium for Biomedical Applications
Tellurium(Te) nanomaterials have aroused a wide interest in semiconductor, thermoelectric, piezoelectric, as well as biomedical applications. The last decades of reports indicated a major nanostructure of one-...
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Chapter and Conference Paper
Aspect-Level Attributed Network Embedding via Variational Graph Neural Networks
Attributed information network embedding (AINE) has been widely used in network analysis. Existing AINE methods mainly focus on preserving network proximities and minimizing the reconstruction loss of node att...
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Article
Open AccessGenome sequence of Bacillus anthracis ty** phage AP631
AP631, a virulent bacteriophage of Bacillus anthracis, is widely used in China to identify anthrax bacteria. In this study, we report the complete AP631 phage genome sequence as well as comparative genomic analys...
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Chapter and Conference Paper
An Approach with Low Redundancy to Network Feature Selection Based on Multiple Order Proximity
Most models for unsupervised network feature selection use first-order proximity and reconstruction loss together as a guiding principle in the selection process
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Chapter and Conference Paper
Combining Meta-Graph and Attention for Recommendation over Heterogenous Information Network
Recently heterogeneous information network (HIN) has gained wide attention in recommender systems due to its flexibility in modeling rich objects and complex relationships. It’s still challenging for HIN based...
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Article
Open AccessDesign and production of conjugate vaccines against S. Paratyphi A using an O-linked glycosylation system in vivo
Enteric fever, mainly caused by Salmonella enterica serovar Paratyphi A, remains a common and serious infectious disease worldwide. As yet, there are no licensed vaccines against S. Paratyphi A. Biosynthesis of c...
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Chapter and Conference Paper
A Semantic Path-Based Similarity Measure for Weighted Heterogeneous Information Networks
In recent years, recommender systems based on heterogeneous information networks (HIN) have gained wide attention. In order to generate more attractive recommendations, weighted heterogeneous information netwo...
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Chapter and Conference Paper
A Weighted Similarity Measure Based on Meta Structure in Heterogeneous Information Networks
Evaluating the similarity between two objects in heterogeneous information network is a significant part of information science. The existing meta-structure based similarity measures only consider one meta-str...
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Article
Open AccessA portable microfluidic platform for rapid molecular diagnostic testing of patients with myeloproliferative neoplasms
The ability to simultaneously detect JAK2 V617F and MPL W515K/L mutations would substantially improve the early diagnosis of myeloproliferative neoplasms (MPNs) and decrease the risk of arterial thrombosis. Th...
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Article
Open AccessDramatically Enhanced Spin Dynamo with Plasmonic Diabolo Cavity
The applications of spin dynamos, which could potentially power complex nanoscopic devices, have so far been limited owing to their extremely low energy conversion efficiencies. Here, we present a unique plasm...
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Article
Open AccessRole of the virulence plasmid in acid resistance of Shigella flexneri
Virulence plasmid (VP) acquisition was a key step in the evolution of Shigella from a non-pathogenic Escherichia coli ancestor to a pathogenic genus. In addition, the co-evolution and co-ordination of chromosomes...
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Article
Open AccessExperimental Validation of Bacillus anthracis A16R Proteogenomics
Anthrax, caused by the pathogenic bacterium Bacillus anthracis, is a zoonosis that causes serious disease and is of significant concern as a biological warfare agent. Validating annotated genes and reannotating m...
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Article
Optimization of Optoelectronic Plasmonic Structures
We discuss the interplay between surface plasmon polaritons (SPPs) and localized shape resonances (LSRs) in a plasmonic structure working as a photo-coupler for a GaAs quantum well photodetector. For a targete...
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Article
Open AccessCharacters of homogentisate oxygenase gene mutation and high clonality of the natural pigment-producing Vibrio choleraestrains
Some microorganisms can produce pigments such as melanin, which has been associated with virulence in the host and with a survival advantage in the environment. In Vibrio cholerae, studies have shown that pigment...
