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Open AccessConformal in-ear bioelectronics for visual and auditory brain-computer interfaces
Brain-computer interfaces (BCIs) have attracted considerable attention in motor and language rehabilitation. Most devices use cap-based non-invasive, headband-based commercial products or microneedle-based inv...
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Open AccessHigh-speed, scanned laser structuring of multi-layered eco/bioresorbable materials for advanced electronic systems
Physically transient forms of electronics enable unique classes of technologies, ranging from biomedical implants that disappear through processes of bioresorption after serving a clinical need to internet-of-...
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Open AccessSoft shape-programmable surfaces by fast electromagnetic actuation of liquid metal networks
Low modulus materials that can shape-morph into different three-dimensional (3D) configurations in response to external stimuli have wide-ranging applications in flexible/stretchable electronics, surgical inst...
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A dynamically reprogrammable surface with self-evolving shape morphing
Dynamic shape-morphing soft materials systems are ubiquitous in living organisms; they are also of rapidly increasing relevance to emerging technologies in soft machines1–3, flexible electronics4,5 and smart medi...
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Open AccessImpact of regular additional endobiliary radiofrequency ablation on survival of patients with advanced extrahepatic cholangiocarcinoma under systemic chemotherapy
Prognosis of patients with advanced extrahepatic cholangiocarcinoma (eCCA) is poor. The current standard first-line treatment is systemic chemotherapy (CT) with gemcitabine and a platinum derivate. Additionall...
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Open AccessDirect-current generators based on conductive polymers for self-powered flexible devices
Direct-current generators, especially those based on the Schottky contacts between conductive polymers and metal electrodes, are efficient in converting mechanical stimuli into electrical energy. In contrast t...
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Open AccessNEK1-mediated retromer trafficking promotes blood–brain barrier integrity by regulating glucose metabolism and RIPK1 activation
Loss-of-function mutations in NEK1 gene, which encodes a serine/threonine kinase, are involved in human developmental disorders and ALS. Here we show that NEK1 regulates retromer-mediated endosomal trafficking by...
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Open AccessUbiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners
RIPK1 is a death-domain (DD) containing kinase involved in regulating apoptosis, necroptosis and inflammation. RIPK1 activation is known to be regulated by its DD-mediated interaction and ubiquitination, thoug...
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Open AccessTranspapillary tissue sampling of biliary strictures: balloon dilatation prior to forceps biopsy improves sensitivity and accuracy
The early and definitive diagnosis of malignant bile duct stenoses is essential for a timely and adequate therapy. However, tissue sampling with transpapillary brush cytology (BC) or forceps biopsy (FB) remain...
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A dominant autoinflammatory disease caused by non-cleavable variants of RIPK1
Activation of RIPK1 controls TNF-mediated apoptosis, necroptosis and inflammatory pathways1. Cleavage of human and mouse RIPK1 after residues D324 and D325, respectively, by caspase-8 separates the RIPK1 kinase d...
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Open AccessHigh Incidence of a Novel Rickettsia Genotype in Parasitic Haemaphysalis longicornis from China-North Korea Border
Ticks are notorious vectors for various pathogens that cause infections in animals and humans worldwide. Rickettsia spp., a zoonotic tick-borne pathogen that could be used as a weapon agent, is widely spread in C...
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Open AccessEffect of curcumin on glycerol-induced acute kidney injury in rats
The aim of this study was to investigate the protective role and underlying mechanisms of curcumin on glycerol-induced acute kidney injury (AKI) in rats. Glycerol (10 ml/kg BW, 50% v/v in sterile saline, i.m.)...
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Open AccessHuman activity accelerating the rapid desertification of the Mu Us Sandy Lands, North China
Over the past several thousand years, arid and semiarid China has experienced a series of asynchronous desertification events in its semiarid sandy and desert regions, but the precise identification of the dri...
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Open AccessWhole-genome sequencing of Oryza brachyantha reveals mechanisms underlying Oryza genome evolution
The wild species of the genus Oryza contain a largely untapped reservoir of agronomically important genes for rice improvement. Here we report the 261-Mb de novo assembled genome sequence of Oryza brachyantha. Lo...
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Holocene climatic change in Hunshandake Desert
Research on the geological data of Hunshandake Desert in China monsoon region revealed that Holocene summer monsoon had experienced six prevailing periods and seven weakening periods. The climatic humidity and...
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Reconstruction of the spatial patterns of desert/loess boundary belt in North China during the Holocene
The desert/loess boundary belt is the transitional region between desert and loess, where aeolian sand and loess interlock in space and alternate in time. It, being seriously unstable in space-time, sensitive ...
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Uplift processes for the Qinghai-Tibet Plateau: A comparative study of Yecheng section and Siwalik group
Comparative studies of the Yecheng section at the northern piedmont of the Kunlun Mountain, and the Surai Khola section at the southern piedmont of the Himalayan Mountain, indicates that the Qinghai-Tibet Plat...
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Discovery of Ordos Cretaceous dune rock and its significance
It has been found that there existed quite a large quantity of dune rocks in the red sandstone of the Zhidan Group of Ordos Cretaceous strata. Their sedimentary structure, grain size and micro-shape of sand gr...
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New views on age of the Salawusu Formation of Late Pleistocene in northern China
The Salawusu Formation in the Salawusu River basin of Inner Mongolia is a typical sequence of the Upper Pleistocene in northern China. However, there have been some different views about the division and age o...