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  1. Article

    Open Access

    Quantitative analysis of phosphoproteome in necroptosis reveals a role of TRIM28 phosphorylation in promoting necroptosis-induced cytokine production

    Necroptosis is a form of regulated necrotic cell death that promotes inflammation. In cells undergoing necroptosis, activated RIPK1 kinase mediates the formation of RIPK1/RIPK3/MLKL complex to promote MLKL oli...

    Rui Zu, Zhen Yu, **g Zhao, **aojuan Lu, Wei Liang, Le Sun… in Cell Death & Disease (2021)

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  2. Article

    Open Access

    Ubiquitination of RIPK1 regulates its activation mediated by TNFR1 and TLRs signaling in distinct manners

    RIPK1 is a death-domain (DD) containing kinase involved in regulating apoptosis, necroptosis and inflammation. RIPK1 activation is known to be regulated by its DD-mediated interaction and ubiquitination, thoug...

    **ngyan Li, Mengmeng Zhang, **nyue Huang, Wei Liang, Ganquan Li… in Nature Communications (2020)

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