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Open AccessExplaining in-vitro to in-vivo efficacy correlations in oncology pre-clinical development via a semi-mechanistic mathematical model
In-vitro to in-vivo correlations (IVIVC), relating in-vitro parameters like IC50 to in-vivo drug exposure in plasma and tumour growth, are widely used in oncology for experimental design and dose decisions. Howev...
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Open AccessCD276 is an important player in macrophage recruitment into the tumor and an upstream regulator for PAI-1
More than 70% of colorectal, prostate, ovarian, pancreatic and breast cancer specimens show expression of CD276 (B7–H3), a potential immune checkpoint family member. Several studies have shown that high CD276 ...
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Open AccessResponse to IL-6 trans- and IL-6 classic signalling is determined by the ratio of the IL-6 receptor α to gp130 expression: fusing experimental insights and dynamic modelling
Interleukin-6 is a pleiotropic cytokine with high clinical relevance and an important mediator of cellular communication, orchestrating both pro- and anti-inflammatory processes. Interleukin-6-induced signalli...
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Open AccessExpression profile of translation initiation factor eIF2B5 in diffuse large B-cell lymphoma and its correlation to clinical outcome
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Open AccessIdentifying differential miR and gene consensus patterns in peripheral blood of patients with cardiovascular diseases from literature data
Numerous recent studies suggest the potential of circulating MicroRNAs (miRs) in peripheral blood samples as diagnostic or prognostic markers for coronary artery disease (CAD), acute coronary syndrome (ACS) an...
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Doxorubicin-induced chronic dilated cardiomyopathy—the apoptosis hypothesis revisited
The chemotherapeutic agent doxorubicin (DOX) has significantly increased survival rates of pediatric and adult cancer patients. However, 10% of pediatric cancer survivors will 10–20 years later develop severe ...
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Harnessing system models of cell death signalling for cytotoxic chemotherapy: towards personalised medicine approaches?
Most cytotoxic chemotherapeutics are believed to kill cancer cells by inducing apoptosis. Understanding the factors that contribute to impairment of apoptosis in cancer cells is therefore critical for the deve...
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Equilibria and stability of a class of positive feedback loops
Positive feedback loops are common regulatory elements in metabolic and protein signalling pathways. The length of such feedback loops determines stability and sensitivity to network perturbations. Here we pro...
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Systems Biology of the Mitochondrial Apoptosis Pathway
Mitochondria have multiple functions. Apart from their role in the regulation of cellular bioenergetics, redox homeostasis and signal transduction, mitochondria are able to initiate apoptosis. The Bcl-2 family...
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Open AccessSiteBinder – an improved approach for comparing multiple protein structural motifs. Case studies on biologically important motifs
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Open AccessDiffusion is capable of translating anisotropic apoptosis initiation into a homogeneous execution of cell death
Apoptosis is an essential cell death process throughout the entire life span of all metazoans and its deregulation in humans has been implicated in many proliferative and degenerative diseases. Mitochondrial o...
