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Article
Open AccessTranscriptomic survey of key reproductive and metabolic tissues in mouse models of polycystic ovary syndrome
Excessive androgen production and obesity are key to polycystic ovary syndrome (PCOS) pathogenesis. Prenatal androgenized (PNA), peripubertal androgenized, and overexpression of nerve growth factor in theca ce...
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Article
Open AccessPrenatal androgen exposure causes a sexually dimorphic transgenerational increase in offspring susceptibility to anxiety disorders
If and how obesity and elevated androgens in women with polycystic ovary syndrome (PCOS) affect their offspring’s psychiatric health is unclear. Using data from Swedish population health registers, we showed t...
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Article
Open AccessSingle-cell analysis of human ovarian cortex identifies distinct cell populations but no oogonial stem cells
The human ovary orchestrates sex hormone production and undergoes monthly structural changes to release mature oocytes. The outer lining of the ovary (cortex) has a key role in defining fertility in women as i...
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Article
Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome
How obesity and elevated androgen levels in women with polycystic ovary syndrome (PCOS) affect their offspring is unclear. In a Swedish nationwide register-based cohort and a clinical case–control study from C...
