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Article
Open AccessSingle-cell RNA-sequencing identifies disease-associated oligodendrocytes in male APP NL-G-F and 5XFAD mice
Alzheimer’s disease (AD) is associated with progressive neuronal degeneration as amyloid-beta (Aβ) and tau proteins accumulate in the brain. Glial cells were recently reported to play an important role in the ...
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Article
Open AccessCRISPR/dCas9-Dnmt3a-mediated targeted DNA methylation of APP rescues brain pathology in a mouse model of Alzheimer’s disease
Aberrant DNA methylation patterns have been observed in neurodegenerative diseases, including Alzheimer's disease (AD), and dynamic changes in DNA methylation are closely associated with the onset and progress...
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Article
Aberrant qNSC activity mediates decreased active neurogenesis in the Shank3 deficient Autism development
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Article
Dormant state of quiescent neural stem cells links Shank3 mutation to autism development
Autism spectrum disorders (ASDs) are common neurodevelopmental disorders characterized by deficits in social interactions and communication, restricted interests, and repetitive behaviors. Despite extensive st...
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Article
Open AccessRad50 mediates DNA demethylation to establish pluripotent reprogramming
DNA demethylation is characterized by the loss of methyl groups from 5-methylcytosine, and this activity is involved in various biological processes in mammalian cell development and differentiation. In partic...
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Article
In vivo neuronal gene editing via CRISPR–Cas9 amphiphilic nanocomplexes alleviates deficits in mouse models of Alzheimer’s disease
In vivo gene editing in post-mitotic neurons of the adult brain may be a useful strategy for treating neurological diseases. Here, we develop CRISPR–Cas9 nanocomplexes and show they were effective in the adult...
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Article
Acupuncture Alleviates Levodopa-Induced Dyskinesia via Melanin-Concentrating Hormone in Pitx3-Deficient aphakia and 6-Hydroxydopamine-Lesioned Mice
Although l-3,4-dihydroxyphenylalanine (L-DOPA) is currently the most effective medication for treating Parkinson’s disease (PD) motor symptoms, its prolonged administration causes several adverse effects, includi...
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Article
Open AccessEffects of a hypomagnetic field on DNA methylation during the differentiation of embryonic stem cells
It has been reported that hypomagnetic fields (HMFs) have a negative influence on mammalian physiological functions. We previously reported that HMFs were detrimental to cell fate changes during reprogramming ...
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Article
Crystal structure of XoLAP, a leucine aminopeptidase, from Xanthomonas oryzae pv. oryzae
Aminopeptidases are metalloproteinases that degrade N-terminal residues from protein and play important roles in cell growth and development by controlling cell homeostasis and protein maturation. We determine...
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Article
Expression of DcHsp17.7, a small heat shock protein gene in carrot (Daucus carota L.)
We examined the expression pattern of the small heat shock protein (sHSP) gene, DcHsp17.7, under various conditions. In non-stressed leaf tissue, DcHsp17.7 was absent or present at very low levels; however, expos...
