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Article
Analysis of dose-response to hexanal-induced gene expression in A549 human alveolar cells
The problems of analyzing dose effects on gene expression are gaining attention in toxicological research. Determining how gene expression profiles change with toxicant dose will improve the utility of arrays ...
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Article
Discovery of characteristic molecular signatures for the simultaneous prediction and detection of environmental pollutants
Gene expression data may be very promising for the classification of toxicant types, but the development and application of transcriptomic-based gene classifiers for environmental toxicological applications ar...
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Article
Integrated analysis of microRNA and mRNA expression profiles highlights alterations in modulation of the apoptosis-related pathway under nonanal exposure
We have shown that aldehydes impact gene expression profiles of bronchial airway associated with pulmonary toxicity. In this study, we aimed to determine whether microRNA (miRNA) plays a role in regulating the...
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Article
Discovery of a characteristic molecular signature by microarray analysis of whole-blood gene expression in workers exposed to volatile organic compounds
The aim of this study was to determine the transcriptomic response in workers exposed to volatile organic compounds (VOCs). As blood is one of the most easily accessible sources of RNA for analyzing environmen...
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Article
Monitoring of deiodinase deficiency based on transcriptomic responses in SH-SY5Y cells
Iodothyronine deiodinase types I, II, and III (D1, D2, and D3, respectively), which constitute a family of selenoenzymes, activate and inactivate thyroid hormones through the removal of specific iodine moietie...
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Article
Analysis of mRNA expression profiles highlights alterations in modulation of the DNA damage-related genes under butanal exposure in A549 human alveolar epithelial cells
Butanal is a lower-molecular-weight saturated aliphatic aldehyde (LSAA) that is known as one of the important causes of indoor pollution. Although a few studies have been reported, the toxicity of butanal and ...
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Article
Benzo[k]fluoranthene-induced changes in miRNA-mRNA interactions in human hepatocytes
Toxicology studies assessing the risk of environmental toxicants in humans frequently use in vitro systems in combination with transcriptomics to characterize toxic responses. Thus far, changes have mostly been i...
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Article
Identification of genes induced by dibutyl phthalate in human thyroid follicular FTC-238 cells
Dibutyl phthalates (DBP) are widely used as plasticizers to soften and increase the flexibility of polyvinyl chloride plastics, although they can leach into the surrounding environment. Many studies have repor...
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Article
Gene expression analysis identifies DNA damage-related markers of benzo[a]pyrene exposure in HepG2 human hepatocytes
Benzo[a]pyrene (BaP) is a polycyclic aromatic hydrocarbon (PAH) that is carcinogenic to humans. Although the environmental distribution and metabolism of BaP have been reported and many researchers are perform...
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Article
Analysis of differentially expressed genes by Mirex ‘persistent organic pollutant’ in HepG2 cells
Mirex is a bioaccumulative, persistent, and toxic pollutant. It is one of 12 priority persistent organic pollutants identified as requiring global action by the United Nations Environment Program (UNEP) Govern...
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Article
The optimal conditions for the estimation of DNA methylation levels using high throughput microarray derived DNA immunoprecipitation (MeDIP)-enrichment in human bloods
Genomic-wide map** of epigenetic changes is essential for understanding the mechanisms involved in chemical-induced gene regulation. The identification of DNA methylation patterns is a common procedure in th...
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Article
Dose-response functional gene analysis by exposure to 3 different polycyclic aromatic hydrocarbons in human hepatocytes
Polycyclic aromatic hydrocarbons (PAHs) are known as carcinogen and have been studied to show modulation of gene expression by exposure to various PAHs. However, few studies have been reported on microarray an...
