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The Mitochondrial Permeability Transition Pore: Molecular Structure and Function in Health and Disease

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  1. Article

    Open Access

    Mitochondrial ATP synthase c-subunit leak channel triggers cell death upon loss of its F1 subcomplex

    Mitochondrial ATP synthase is vital not only for cellular energy production but also for energy dissipation and cell death. ATP synthase c-ring was suggested to house the leak channel of mitochondrial permeabi...

    Nelli Mnatsakanyan, Han-A Park, **g Wu, **ang He… in Cell Death & Differentiation (2022)

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  2. Article

    Open Access

    Inhibition of Bcl-xL prevents pro-death actions of ΔN-Bcl-xL at the mitochondrial inner membrane during glutamate excitotoxicity

    ABT-737 is a pharmacological inhibitor of the anti-apoptotic activity of B-cell lymphoma-extra large (Bcl-xL) protein; it promotes apoptosis of cancer cells by occupying the BH3-binding pocket. We have shown p...

    Han-A Park, Pawel Licznerski, Nelli Mnatsakanyan… in Cell Death & Differentiation (2017)

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