18 Result(s)

Article

Neoadjuvant chemotherapy remodels the tumor immune microenvironment by increasing activated and cytotoxic T cell, decreasing B cells and macrophages in small cell lung cancer

**aoling Shang, Chenyue Zhang, Kai Wang, Haiyong Wang in Journal of Translational Medicine (2023)

Article

Orchestrating smart therapeutics to achieve optimal treatment in small cell lung cancer: recent progress and future directions

Small cell lung cancer (SCLC) is a recalcitrant malignancy with elusive mechanism of pathogenesis and dismal prognosis. Over the past decades, platinum-based chemotherapy has been the backbone treatment for SC...

Chenyue Zhang, Chenxing Zhang, Kai Wang, Haiyong Wang in Journal of Translational Medicine (2023)

Article

Acupuncture for chemotherapy-associated insomnia in breast cancer patients: an assessor-participant blinded, randomized, sham-controlled trial

Insomnia is a highly prevalent symptom occurred during and post-chemotherapy. Acupuncture may have beneficial effects in the management of chemotherapy-associated insomnia. This study was conducted to determin...

Jialing Zhang, Zongshi Qin, Tsz Him So, Tien Yee Chang… in Breast Cancer Research (2023)

Article

Useful preclinical clues that a proposed new therapy would work in the clinic: to make a medicinal chemist’s dreams come true

Daniel D. Von Hoff, Haiyong Han in Medicinal Chemistry Research (2022)

Article

The regulation of autophagy by the miR-199a-5p/p62 axis was a potential mechanism of small cell lung cancer cisplatin resistance

Autophagy has been found to be involved in the multidrug resistance (MDR) of cancers, but whether it is associated with resistance of small cell lung cancer (SCLC) has not been studied. Here, we hypothesized t...

Tiezhi Li, Helin Zhang, Zhichao Wang, Shaolin Gao, Xu Zhang… in Cancer Cell International (2022)

Article

Retraction Note: Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer

This article has been retracted. Please see the Retraction Notice for more detail: https://doi.org/10.1186/s13046-021-02052-z.

Haiyong Zhang, **g Wu, **qiu Yuan… in Journal of Experimental & Clinical Cancer … (2022)

Article

Antidepressant Monotherapy and Combination Therapy with Acupuncture in Depressed Patients: A Resting-State Functional Near-Infrared Spectroscopy (fNIRS) Study

Depression is a common psychiatric illness affecting over 300 million people globally. Acupuncture has been reported to be a safe complementary treatment for depression. This study is aimed to investigate the ...

Yat Kwan Wong, Jun Mei Wu, Guodong Zhou, Frank Zhu, Quan Zhang… in Neurotherapeutics (2021)

Article

Loss of heterozygosity related to TMB and TNB may predict PFS for patients with SCLC received the first line setting

Chenyue Zhang, Kai Wang, Haiyong Wang in Journal of Translational Medicine (2021)

Article

RETRACTED ARTICLE: Ethaselen synergizes with oxaliplatin in tumor growth inhibition by inducing ROS production and inhibiting TrxR1 activity in gastric cancer

Haiyong Zhang, **g Wu, **qiu Yuan… in Journal of Experimental & Clinical Cancer … (2021)

Article

A new nomogram and risk classification system for predicting survival in small cell lung cancer patients diagnosed with brain metastasis: a large population-based study

The prognosis of patients with small cell lung cancer (SCLC) is poor, most of them are in the extensive stage at the time of diagnosis, and are prone to brain metastasis. In this study, we established a nomogr...

Qinge Shan, Jianxiang Shi, **aohui Wang, Jun Guo, **ao Han, Zhehai Wang… in BMC Cancer (2021)

Article

CD44, a marker of cancer stem cells, is positively correlated with PD-L1 expression and immune cells infiltration in lung adenocarcinoma

PD-L1 inhibitors is widely applied in lung adenocarcinoma patients. Tumor cells with high PD-L1 expression could trigger immune evasion. Cancer stem cells (CSCs) can evade from immunesurveillance due to their ...

Chenyue Zhang, Hui Wang, **a Wang, Chenglong Zhao… in Cancer Cell International (2020)

Article

Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions

Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor cells constantly interact. Detailed characterization of the cellular ...

Wei Lin, Pawan Noel, Erkut H. Borazanci, Jeeyun Lee, Albert Amini… in Genome Medicine (2020)

Article

A hypothesized TNM staging system based on the number and location of positive lymph nodes may better reflect the prognosis for patients with NSCLC

This study aimed to evaluate the feasibility and prognostic accuracy of incorporating the number of positive lymph nodes (PLN) into the TNM staging system for non-small cell lung cancer (NSCLC) patients.

**aoling Shang, Jia Liu, Zhenxiang Li, Jiamao Lin, Haiyong Wang in BMC Cancer (2019)

Article

Clinical study of genomic drivers in pancreatic ductal adenocarcinoma

Pancreatic ductal adenocarcinoma (PDA) is a lethal cancer with complex genomes and dense fibrotic stroma. This study was designed to identify clinically relevant somatic aberrations in pancreatic cancer genome...

Michael T Barrett, Ray Deiotte, Elizabeth Lenkiewicz… in British Journal of Cancer (2017)

Article

Establishment of patient-derived gastric cancer xenografts: a useful tool for preclinical evaluation of targeted therapies involving alterations in HER-2, MET and FGFR2 signaling pathways

Targeted therapies are emerging treatment options for gastric cancer (GC). Patient-derived tumor xenograft(PDX) models of GC closely retain the features of the original clinical cancer, offering a powerful too...

Haiyong Wang, Jun Lu, Jian Tang, Shitu Chen, Kuifeng He, **aoxia Jiang… in BMC Cancer (2017)

Article

From rabbit antibody repertoires to rabbit monoclonal antibodies

In this review, we explain why and how rabbit monoclonal antibodies have become outstanding reagents for laboratory research and increasingly for diagnostic and therapeutic applications. Starting with the uniq...

Justus Weber, Haiyong Peng, Christoph Rader in Experimental & Molecular Medicine (2017)

Article

Luteolin exerts a marked antitumor effect in cMet-overexpressing patient-derived tumor xenograft models of gastric cancer

Aberrated activation of cMet in gastric cancer contributes to tumor growth, angiogenesis and metastasis. cMet-overexpressing gastric cancer has a poor prognosis because of high tumor metastasis and limited the...

Jun Lu, Guangliang Li, Kuifeng He, Weiqin Jiang… in Journal of Translational Medicine (2015)

Article

Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells

Tumor Necrosis Factor-α Related Apoptosis Inducing Ligand (TRAIL) and agonistic antibodies to death receptor 4 and 5 are promising candidates for cancer therapy due to their ability to induce apoptosis selective...

David J Taylor, Christine E Parsons, Haiyong Han, Arul Jayaraman… in BMC Cancer (2011)