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Investigation report on the emotion and behavior of employees in the process of optimizing the prevention and control measures for novel coronavirus infection
Since the issuance of the Notice on Further Optimizing the Implementation of COVID-19 Prevention and Control Measures on December 7, 2022, employees have returned to work and production after completing remote...
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Open AccessRNA modification in cardiovascular disease: implications for therapeutic interventions
Cardiovascular disease (CVD) is the leading cause of death in the world, with a high incidence and a youth-oriented tendency. RNA modification is ubiquitous and indispensable in cell, maintaining cell homeosta...
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Article
Open AccessSkp2-mediated MLKL degradation confers cisplatin-resistant in non-small cell lung cancer cells
Non-small cell lung cancer (NSCLC) is the most prevalent type of cancer and the leading cause of cancer-related death. Chemotherapeutic resistance is a major obstacle in treating NSCLC patients. Here, we disco...
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Macrobenthic community structure of Rudong coastal wetland, China: the impact of invasive Spartina alterniflora and its implication for migratory bird conservation
Spartina alterniflora is an invasive plant whose effects on macrobenthic communities are still unclear. The Rudong coast has been invaded by S. alterniflora for years. The effects of S. alterniflora on the macrob...
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Open AccessCorrection to: Stabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance
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Open AccessStabilization of MCL-1 by E3 ligase TRAF4 confers radioresistance
The E3 ligase TNF receptor-associated factor 4 (TRAF4) is frequently overexpressed and closely related to poor prognosis in human malignancies. However, its effect on carcinogenesis and radiosensitivity in ora...
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Open AccessEvolutionary game model of health care and social care collaborative services for the elderly population in China
The synergy of health care and elderly social care organizations has become the focus of the research on integrated health care and social care. This study aims to propose a collaborative strategy among health...
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Open AccessSkp2 stabilizes Mcl-1 and confers radioresistance in colorectal cancer
Overexpression of Skp2 plays a critical role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, Skp2 has been proposed as an attractive target for anti-tumor interventions. The ex...
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Open AccessTargeting Aurora B kinase with Tanshinone IIA suppresses tumor growth and overcomes radioresistance
Aurora B kinase is aberrantly overexpressed in various tumors and shown to be a promising target for anti-cancer therapy. In human oral squamous cell carcinoma (OSCC), the high protein level of Aurora B is req...
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Article
Open AccessRIP1/RIP3/MLKL-mediated necroptosis contributes to vinblastine-induced myocardial damage
Vinblastine (VBL) has been considered as a first-line anti-tumor drug for many years. However, vinblastine-caused myocardial damage has been continually reported. The underlying molecular mechanism of the myoc...
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Open AccessUbiquitination of the DNA-damage checkpoint kinase CHK1 by TRAF4 is required for CHK1 activation
Aberrant activation of DNA damage response (DDR) is a major cause of chemoresistance in colorectal cancer (CRC). CHK1 is upregulated in CRC and contributes to therapeutic resistance. We investigated the upstre...
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Open AccessDeguelin suppresses non-small cell lung cancer by inhibiting EGFR signaling and promoting GSK3β/FBW7-mediated Mcl-1 destabilization
Activating mutations of epidermal growth factor receptor (EGFR) play crucial roles in the oncogenesis of human non-small cell lung cancer (NSCLC). By screening 79 commercially available natural products, we fo...
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Skp2-mediated ubiquitination and mitochondrial localization of Akt drive tumor growth and chemoresistance to cisplatin
The E3 ligase S-phase kinase-associated protein 2(Skp2) is overexpressed in human cancers and correlated with poor prognosis, but its contributions to tumorigenesis and chemoresistance in nasopharyngeal carcin...
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Open AccessTargeting MCL-1 sensitizes human esophageal squamous cell carcinoma cells to cisplatin-induced apoptosis
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies in China and is an exceptionally drug-resistant tumor with a 5-year survival rate less than 15%. Cisplatin is the most commonly ...
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Article
AID expression increased by TNF-α is associated with class switch recombination of Igα gene in cancers
Recently, immunoglobulins (Igs) were unexpectedly found to be expressed in epithelial cancers. Immunoglobulin class switching or class switch recombination (CSR) is a natural biological process that alters a B...
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Activation of the Ig Iα1 promoter by the transcription factor Ets-1 triggers Ig Iα1–Cα1 germline transcription in epithelial cancer cells
Immunoglobulins (Igs) are known to be synthesized and secreted only by B lymphocytes. Class switch recombination (CSR) is a key event that enables B cells to express Igs, and one of the crucial steps for CSR i...
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Open AccessRegulation of Mcl-1 by constitutive activation of NF-kappaB contributes to cell viability in human esophageal squamous cell carcinoma cells
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies with a 5-year survival rate less than 15%. Understanding of the molecular mechanisms involved in the pathogenesis of ESCC become...
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Promotion of cell proliferation and inhibition of ADCC by cancerous immunoglobulin expressed in cancer cell lines
To explore the significance of cancerous immunoglobulin (Ig) in cancer cell growth, HeLa cervical cancer cells were stably transfected with small interfering RNA (siRNA) that specifically, efficiently and cons...
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Heterogeneity of aberrant immunoglobulin expression in cancer cells
Accumulating evidence has shown that immunoglobulin (Ig) is ‘unexpectedly’ expressed by epithelial cancer cells and that it can promote tumor growth. The main purpose of this study was to explore the component...
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Open AccessLMP1-augmented kappa intron enhancer activity contributes to upregulation expression of Ig kappa light chain via NF-kappaB and AP-1 pathways in nasopharyngeal carcinoma cells
Expression of kappa gene is under the control of distinct cis-regulatory elements, including the kappa intron enhancer (iEκ) and the kappa 3' enhancer (3'Eκ). The active enhancers and expression of immunoglobulin...
